Phosphorylation of -catenin by CKI and GSK-3 leads to its ubiquitination and subsequent breakdown in the proteossome.

Homoloques and Positional Isomers of CDDs, CDFs Members of the EPCRA Section 313 Dioxin and Dioxin-like Compounds Category Average Emission Factors (pg/L) for Estimating Wastewater Discharges of Dioxin and Dioxin-like Compounds into Surface Water From Bleached Chemical Pulp Mills Average Emission Factors (ng/kg) for Land Disposal of Dioxin and Dioxin-like Compounds in Wastewater Sludge From Bleached Chemical Pulp Mills Average Emission Factors (ng/kg) for Air Releases of Dioxin and Dioxin-like Compounds From the Combustion of Wood Waste and Bark (as fired) at Pulp Mill or Lumber and Wood Product Industry Facility Boilers Average Emission Factors (ng/kg scrap aluminum processed) For Estimating Air Releases of Dioxin and Dioxin-like Compounds From Secondary Aluminum Smelters Average Emission Factors (ng/kg) For Estimating Air Releases of Dioxin and Dioxin like Compounds From Secondary Lead Smelters CDD/CDF Emission Factors (ng Dioxin and Dioxin-like Compounds per kg copper scrap processed) For Secondary Copper Smelters Average Emission Factors (ng/kg cement clinker produced) For Estimating Air Releases of Dioxin and Dioxin-like Compounds From Cement Kilns Not Combusting Hazardous Waste as Supplemental Fuel Average Emission Factors (ng/kg coal combusted) For Estimating Air Releases of Dioxin and Dioxin-like Compounds From Coal-Fired Utility Boilers Average Emission Factors (pg/L oil combusted) For Estimating Air Releases of Dioxin and Dioxin-like Compounds From Oil-Fired Utility Boilers Average Emission Factors (ng/kg of wood combusted) For Estimating Air Releases of Dioxin and Dioxin-like Compounds From Wood-Fired Electric Utility Boilers Average Emission Factors (ng/kg waste feed) For Estimating Air Releases of Dioxin and Dioxin-like Compounds From Boilers and Industrial Furnaces Burning Hazardous Waste (other than cement kilns) Average Emission Factors (ng per dscm) For Estimating Air Releases of Dioxin and Dioxin-like Compounds From Cement Kilns Combusting Hazardous Waste as Supplemental Fuel Table 4-13.

Nevertheless, also interactions with proteins may lead to DNA damage.

Georgia-Pacific also objects to these requests to the extent that they are not limited by relevant scope, time period or to 18 products that are relevant to this case and, therefore, are not reasonably calculated to 19 lead to the discovery of admissible evidence.

ANSWER: Honeywell objects to this Interrogatory on the grounds that it is overly broad, unduly burdensome and seeks information not reasonably calculated to lead to the discovery of a

ANSWER: Honeywell objects to this Interrogatory on the grounds that it is overly broad, unduly burdensome and seeks information not reasonably calculated to lead to the discovery of a

MECHANISMS OF CONTAMINATION OF SOILS WITH DIOXIN-LIKE COMPOUNDS IN BACKGROUND AREAS IN MICHIGAN, USA Franzblau A1, Demond A2, Towey T3, Adriaens P2, Chang SC4, Garabrant D1, Gillespie B5, Hong B5, Lepkowski J5, Luksemburg W7, Maier M7 1Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109; 2Department of Civil and Environmental Engineering, University of Michigan College of Engineering, Ann Arbor, MI 48109; 3Limnotech, Ann Arbor, MI 48108; 4Department of Environmental Engineering, National Chung Hsing University, Taichung 402, Taiwan; 5Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI 48109; 6Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48109; 7Vista Analytical Laboratory, El Dorado Hills, California 95762 Introduction The University of Michigan Dioxin Exposure Study (UMDES) was undertaken in response to concerns among the population of Midland and Saginaw Counties in Michigan, USA, that the discharge of dioxin-like compounds from the Dow Chemical Company facilities in Midland, Michigan, USA, had resulted in contamination of soils in the Tittabawassee River flood plain and areas of the City of Midland, leading to an increase in residents' body burdens of dioxin-like compounds.

Exposure may also come from fibres carried home on the clothing of asbestos workers.4 Upcoming meetings June 2-9, 2009 Radiation September 29-October 6, 2009 Lifestyle Factors October 20-27, 2009 Chemical Agents and Related Occupations http://monographs.iarc.fr/ Group 1 agent Tumour sites (or types) for which there is sufficient evidence in humans Other sites with limited evidence in humans Established mechanistic events Arsenic and inorganic arsenic compounds Lung, skin, urinary bladder Beryllium and beryllium compounds Lung Cadmium and cadmium compounds Lung Chromium (VI) compounds Lung Kidney, liver, prostate Prostate, kidney Nasal cavity and paranasal sinuses Oxidative DNA damage, genomic instability, aneuploidy, gene amplification, epigenetic effects, DNA-repair inhibition leading to mutagenesis Chromosome aberrations, aneuploidy, DNA damage DNA-repair inhibition, disturbance of tumour-suppressor proteins leading to genomic instability Direct DNA damage after intracellular reduction to Cr(III), mutation, genomic instability, aneuploidy, cell transformation Nickel compounds Asbestos (chrysotile, crocidolite, amosite, tremolite, actinolite, and anthophyllite) Lung, nasal cavity, and paranasal sinuses DNA damage, chromosome aberrations, genomic instability, micronuclei, DNA-repair inhibition, alteration of DNA methylation, histone modification Lung, mesothelioma, larynx, ovary Colorectum, pharynx, stomach Impaired fibre clearance leading to macrophage activation, inflammation, generation of reactive oxygen and nitrogen species, tissue injury, genotoxicity, aneuploidy and polyploidy, epigenetic alteration, activation of signalling pathways, resistance to apoptosis Erionite Mesothelioma Genotoxicity Silica dust, crystalline in the form of Lung quartz or crystobalite Impaired particle clearance leading to macrophage activation and persistent inflammation Leather dust Wood dust Nasal cavity and paranasal sinuses Nasal cavity and paranasal sinuses, nasopharynx Table: Metals, arsenic, dusts, and fibres assessed by the IARC Monograph Working Group www.thelancet.com/oncology Vol 10 May 2009 453 News Monograph Working Group Members U Heinrich-Co-Chair (Germany), J Samet--Co-Chair (USA); P A Demers, M Gerin, J Siemiatycki (Canada); P Grandjean (Denmark); A Aitio, T Kauppinen (Finland); M Goldberg (France); A Hartwig, H Muhle (Germany); B Fubini, F Merletti (Italy); M Ikeda (Japan); M D Attfield, K P Cantor, B A Fowler, R Henderson, P F Infante, AB Kane, P J Landrigan, R Lunn, T G Rossman, L Stayner, M P Waalkes, E M Ward, J M Ward (USA) Conflicts ofinterest RH served as chair of the US EPA Clean Air Seminar Advisory Committee from 2004 to 2008, which reviews US air standards for noxious gases and particulate matter.

Exposure may also come from fibres carried home on the clothing of asbestos workers.4 Upcoming meetings June 29, 2009 Radiation September 29October 6, 2009 Lifestyle Factors October 2027, 2009 Chemical Agents and Related Occupations http://monographs.iarc.fr/ Group 1 agent Tumour sites (or types) for which Other sites with Established mechanistic events there is sufficient evidence in limited evidence humans in humans Arsenic and inorganic arsenic compounds Lung, skin, urinary bladder Kidney, liver, prostate Oxidative DNA damage, genomic instability, aneuploidy, gene amplification, epigenetic effects, DNA-repair inhibition leading to mutagenesis Beryllium and beryllium compounds Lung Chromosome aberrations, aneuploidy, DNA damage Cadmium and cadmium compounds Lung Prostate, kidney DNA-repair inhibition, disturbance of tumour-suppressor proteins leading to genomic instability Chromium (VI) compounds Lung Nasal cavity and Direct DNA damage after intracellular reduction to Cr(III), mutation, genomic instability, paranasal sinuses aneuploidy, cell transformation Nickel compounds Lung, nasal cavity, and paranasal sinuses DNA damage, chromosome aberrations, genomic instability, micronuclei, DNA-repair inhibition, alteration of DNA methylation, histone modification Asbestos (chrysotile, crocidolite, amosite, tremolite, actinolite, and anthophyllite) Lung, mesothelioma, larynx, ovary Colorectum, Impaired fibre clearance leading to macrophage activation, inflammation, generation of reactive pharynx, stomach oxygen and nitrogen species, tissue injury, genotoxicity, aneuploidy and polyploidy, epigenetic alteration, activation of signalling pathways, resistance to apoptosis Erionite Mesothelioma Genotoxicity Silica dust, crystalline in the form of Lung quartz or crystobalite Impaired particle clearance leading to macrophage activation and persistent inflammation Leather dust Nasal cavity and paranasal sinuses Wood dust Nasal cavity and paranasal sinuses, nasopharynx Table: Metals, arsenic, dusts, and fibres assessed by the IARC Monograph Working Group www.thelancet.com/oncology Vol 10 May 2009 453 News Monograph Working Group Members U Heinrich--Co-Chair (Germany), J Samet--Co-Chair (USA); P A Demers, M Grin, J Siemiatycki (Canada); P Grandjean (Denmark); A Aitio, T Kauppinen (Finland); M Goldberg (France); A Hartwig, H Muhle (Germany); B Fubini, F Merletti (Italy); M Ikeda (Japan); M D Attfield, K P Cantor, B A Fowler, R Henderson, P F Infante, AB Kane, P J Landrigan, R Lunn, T G Rossman, L Stayner, M P Waalkes, E M Ward, J M Ward (USA) Conflicts of interest RH served as chair of the US EPA Clean Air Seminar Advisory Committee from 2004 to 2008, which reviews US air standards for noxious gases and particulate matter.

Exposure may also come from fibres carried home on the clothing of asbestos workers.4 Upcoming meetings June 29, 2009 Radiation September 29October 6, 2009 Lifestyle Factors October 2027, 2009 Chemical Agents and Related Occupations http://monographs.iarc.fr/ Group 1 agent Tumour sites (or types) for which Other sites with Established mechanistic events there is sufficient evidence in limited evidence humans in humans Arsenic and inorganic arsenic compounds Lung, skin, urinary bladder Kidney, liver, prostate Oxidative DNA damage, genomic instability, aneuploidy, gene amplification, epigenetic effects, DNA-repair inhibition leading to mutagenesis Beryllium and beryllium compounds Lung Chromosome aberrations, aneuploidy, DNA damage Cadmium and cadmium compounds Lung Prostate, kidney DNA-repair inhibition, disturbance of tumour-suppressor proteins leading to genomic instability Chromium (VI) compounds Lung Nasal cavity and Direct DNA damage after intracellular reduction to Cr(III), mutation, genomic instability, paranasal sinuses aneuploidy, cell transformation Nickel compounds Lung, nasal cavity, and paranasal sinuses DNA damage, chromosome aberrations, genomic instability, micronuclei, DNA-repair inhibition, alteration of DNA methylation, histone modification Asbestos (chrysotile, crocidolite, amosite, tremolite, actinolite, and anthophyllite) Lung, mesothelioma, larynx, ovary Colorectum, Impaired fibre clearance leading to macrophage activation, inflammation, generation of reactive pharynx, stomach oxygen and nitrogen species, tissue injury, genotoxicity, aneuploidy and polyploidy, epigenetic alteration, activation of signalling pathways, resistance to apoptosis Erionite Mesothelioma Genotoxicity Silica dust, crystalline in the form of Lung quartz or crystobalite Impaired particle clearance leading to macrophage activation and persistent inflammation Leather dust Nasal cavity and paranasal sinuses Wood dust Nasal cavity and paranasal sinuses, nasopharynx Table: Metals, arsenic, dusts, and fibres assessed by the IARC Monograph Working Group www.thelancet.com/oncology Vol 10 May 2009 453 News Monograph Working Group Members U Heinrich--Co-Chair (Germany), J Samet--Co-Chair (USA); P A Demers, M Grin, J Siemiatycki (Canada); P Grandjean (Denmark); A Aitio, T Kauppinen (Finland); M Goldberg (France); A Hartwig, H Muhle (Germany); B Fubini, F Merletti (Italy); M Ikeda (Japan); M D Attfield, K P Cantor, B A Fowler, R Henderson, P F Infante, AB Kane, P J Landrigan, R Lunn, T G Rossman, L Stayner, M P Waalkes, E M Ward, J M Ward (USA) Conflicts of interest RH served as chair of the US EPA Clean Air Seminar Advisory Committee from 2004 to 2008, which reviews US air standards for noxious gases and particulate matter.

The vertical fuel-elementcharging and control-rod tubes and the horuontal water-discharge pipes lead* ing from these tubes to the header* form a large part of the top shield.

Exposure may also come from fibres carried home on the clothing of asbestos workers.4 Upcoming meetings June 29, 2009 Radiation September 29October 6, 2009 Lifestyle Factors October 2027, 2009 Chemical Agents and Related Occupations http://monographs.iarc.fr/ Group 1 agent Tumour sites (or types) for which Other sites with Established mechanistic events there is sufficient evidence in limited evidence humans in humans Arsenic and inorganic arsenic compounds Lung, skin, urinary bladder Kidney, liver, prostate Oxidative DNA damage, genomic instability, aneuploidy, gene amplification, epigenetic effects, DNA-repair inhibition leading to mutagenesis Beryllium and beryllium compounds Lung Chromosome aberrations, aneuploidy, DNA damage Cadmium and cadmium compounds Lung Prostate, kidney DNA-repair inhibition, disturbance of tumour-suppressor proteins leading to genomic instability Chromium (VI) compounds Lung Nasal cavity and Direct DNA damage after intracellular reduction to Cr(III), mutation, genomic instability, paranasal sinuses aneuploidy, cell transformation Nickel compounds Lung, nasal cavity, and paranasal sinuses DNA damage, chromosome aberrations, genomic instability, micronuclei, DNA-repair inhibition, alteration of DNA methylation, histone modification Asbestos (chrysotile, crocidolite, amosite, tremolite, actinolite, and anthophyllite) Lung, mesothelioma, larynx, ovary Colorectum, Impaired fibre clearance leading to macrophage activation, inflammation, generation of reactive pharynx, stomach oxygen and nitrogen species, tissue injury, genotoxicity, aneuploidy and polyploidy, epigenetic alteration, activation of signalling pathways, resistance to apoptosis Erionite Mesothelioma Genotoxicity Silica dust, crystalline in the form of Lung quartz or crystobalite Impaired particle clearance leading to macrophage activation and persistent inflammation Leather dust Nasal cavity and paranasal sinuses Wood dust Nasal cavity and paranasal sinuses, nasopharynx Table: Metals, arsenic, dusts, and fibres assessed by the IARC Monograph Working Group www.thelancet.com/oncology Vol 10 May 2009 453 News Monograph Working Group Members U Heinrich--Co-Chair (Germany), J Samet--Co-Chair (USA); P A Demers, M Grin, J Siemiatycki (Canada); P Grandjean (Denmark); A Aitio, T Kauppinen (Finland); M Goldberg (France); A Hartwig, H Muhle (Germany); B Fubini, F Merletti (Italy); M Ikeda (Japan); M D Attfield, K P Cantor, B A Fowler, R Henderson, P F Infante, AB Kane, P J Landrigan, R Lunn, T G Rossman, L Stayner, M P Waalkes, E M Ward, J M Ward (USA) Conflicts of interest RH served as chair of the US EPA Clean Air Seminar Advisory Committee from 2004 to 2008, which reviews US air standards for noxious gases and particulate matter.

Exposure may also come from fibres carried home on the clothing of asbestos workers.4 Upcoming meetings June 29, 2009 Radiation September 29October 6, 2009 Lifestyle Factors October 2027, 2009 Chemical Agents and Related Occupations http://monographs.iarc.fr/ Group 1 agent Tumour sites (or types) for which Other sites with Established mechanistic events there is sufficient evidence in limited evidence humans in humans Arsenic and inorganic arsenic compounds Lung, skin, urinary bladder Kidney, liver, prostate Oxidative DNA damage, genomic instability, aneuploidy, gene amplification, epigenetic effects, DNA-repair inhibition leading to mutagenesis Beryllium and beryllium compounds Lung Chromosome aberrations, aneuploidy, DNA damage Cadmium and cadmium compounds Lung Prostate, kidney DNA-repair inhibition, disturbance of tumour-suppressor proteins leading to genomic instability Chromium (VI) compounds Lung Nasal cavity and Direct DNA damage after intracellular reduction to Cr(III), mutation, genomic instability, paranasal sinuses aneuploidy, cell transformation Nickel compounds Lung, nasal cavity, and paranasal sinuses DNA damage, chromosome aberrations, genomic instability, micronuclei, DNA-repair inhibition, alteration of DNA methylation, histone modification Asbestos (chrysotile, crocidolite, amosite, tremolite, actinolite, and anthophyllite) Lung, mesothelioma, larynx, ovary Colorectum, Impaired fibre clearance leading to macrophage activation, inflammation, generation of reactive pharynx, stomach oxygen and nitrogen species, tissue injury, genotoxicity, aneuploidy and polyploidy, epigenetic alteration, activation of signalling pathways, resistance to apoptosis Erionite Mesothelioma Genotoxicity Silica dust, crystalline in the form of Lung quartz or crystobalite Impaired particle clearance leading to macrophage activation and persistent inflammation Leather dust Nasal cavity and paranasal sinuses Wood dust Nasal cavity and paranasal sinuses, nasopharynx Table: Metals, arsenic, dusts, and fibres assessed by the IARC Monograph Working Group www.thelancet.com/oncology Vol 10 May 2009 453 News Monograph Working Group Members U Heinrich--Co-Chair (Germany), J Samet--Co-Chair (USA); P A Demers, M Grin, J Siemiatycki (Canada); P Grandjean (Denmark); A Aitio, T Kauppinen (Finland); M Goldberg (France); A Hartwig, H Muhle (Germany); B Fubini, F Merletti (Italy); M Ikeda (Japan); M D Attfield, K P Cantor, B A Fowler, R Henderson, P F Infante, AB Kane, P J Landrigan, R Lunn, T G Rossman, L Stayner, M P Waalkes, E M Ward, J M Ward (USA) Conflicts of interest RH served as chair of the US EPA Clean Air Seminar Advisory Committee from 2004 to 2008, which reviews US air standards for noxious gases and particulate matter.

This involves scarring of the lung tissue and can lead to breathing difficulties.

Exposure may also come from fibres carried home on the clothing of asbestos workers.4 Upcoming meetings June 2-9, 2009 Radiation September 29-October 6, 2009 Lifestyle Factors October 20-27, 2009 Chemical Agents and Related Occupations http://monographs.iarc.fr/ Group 1 agent Tumour sites (or types) for which there is sufficient evidence in humans Other sites with limited evidence in humans Established mechanistic events Arsenic and inorganic arsenic compounds Lung, skin, urinary bladder Beryllium and beryllium compounds Lung Cadmium and cadmium compounds Lung Chromium (VI) compounds Lung Kidney, liver, prostate Prostate, kidney Nasal cavity and paranasal sinuses Oxidative DNA damage, genomic instability, aneuploidy, gene amplification, epigenetic effects, DNA-repair inhibition leading to mutagenesis Chromosome aberrations, aneuploidy, DNA damage DNA-repair inhibition, disturbance of tumour-suppressor proteins leading to genomic instability Direct DNA damage after intracellular reduction to Cr(III), mutation, genomic instability, aneuploidy, cell transformation Nickel compounds Asbestos (chrysotile, crocidolite, amosite, tremolite, actinolite, and anthophyllite) Lung, nasal cavity, and paranasal sinuses DNA damage, chromosome aberrations, genomic instability, micronuclei, DNA-repair inhibition, alteration of DNA methylation, histone modification Lung, mesothelioma, larynx, ovary Colorectum, pharynx, stomach Impaired fibre clearance leading to macrophage activation, inflammation, generation of reactive oxygen and nitrogen species, tissue injury, genotoxicity, aneuploidy and polyploidy, epigenetic alteration, activation of signalling pathways, resistance to apoptosis Erionite Mesothelioma Genotoxicity Silica dust, crystalline in the form of Lung quartz or crystobalite Impaired particle clearance leading to macrophage activation and persistent inflammation Leather dust Wood dust Nasal cavity and paranasal sinuses Nasal cavity and paranasal sinuses, nasopharynx Table: Metals, arsenic, dusts, and fibres assessed by the IARC Monograph Working Group www.thelancet.com/oncology Vol 10 May 2009 453 News Monograph Working Group Members U Heinrich-Co-Chair (Germany), J Samet--Co-Chair (USA); P A Demers, M Gerin, J Siemiatycki (Canada); P Grandjean (Denmark); A Aitio, T Kauppinen (Finland); M Goldberg (France); A Hartwig, H Muhle (Germany); B Fubini, F Merletti (Italy); M Ikeda (Japan); M D Attfield, K P Cantor, B A Fowler, R Henderson, P F Infante, AB Kane, P J Landrigan, R Lunn, T G Rossman, L Stayner, M P Waalkes, E M Ward, J M Ward (USA) Conflicts ofinterest RH served as chair of the US EPA Clean Air Seminar Advisory Committee from 2004 to 2008, which reviews US air standards for noxious gases and particulate matter.