_ IAA& Final Report on A Pharmacokinetic Study of Potassium Perfluorooctanoate in the Cynomolgus Monkey ./ To: 3M Corporation P.O.

M R A - l *7^ OTHER HALOGENATED POPs OF CONCERN LEVELS OF PERFLUOROOCTANE SULFONATE (PFOS) AND OTHER RELATED COMPOUNDS IN THE BLOOD OF JAPANESE PEOPLE Shieeki Masunaea1.

3M FLUOROCHEMICAL SUBMISSIONS February, 2002 - May, 2004 INDEX OF 3M'S 2002-2004 AR-226 DOCKET SUBMISSIONS BY DATE Back to Menu SEPTEMBER 2002 Click on Study Title to View Report September 17, 2002 September 17, 2002 Submission Cover Letter PFOA Study Data: Raw Estrous Cycling Data for P and F1 Females from Argus Research Protocol 418-020, "Oral (Gavage) Two-Generation (One Litter per Generation) Reproduction Study of Ammonium Perfluorooctanoate (APFO) in Rats."

C O V /H H > THE DEVELOPMENT SERVICES COMPANY Sponsor: 3M St.

STUDY TITLE Extraction of Potassium Perfluorooctanesulfonate from Mallard Serum and Mallard Liver for Analysis Using HPLC-Electrospray/Mass Spectrometry DATA REQUIREMENTS Analytical Method Requirements STUDY DIRECTOR Sean Gallagher STUDY COMPLETED ON September 06, 2001 PERFORMING LABORATORY / TESTING FACILITY Centre Analytical Laboratories, Inc.

3IVI General Offices 6HQ. 0104- -005733M Center St.

3M General Offices 3M Center St.

A X > 6 'I 8 S ^ Toxicological Summary PFOS Dietary Chronic Definitive Reproductive Study: Northern Bobwhite Test Substance: Perfluorooctanesulfonate (PFOS) Structure: 1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro, potassium salt.

AR226-2103 Test Results Sample Data Range Concentration Range A ction Level Industrial Hygiene 1/1/94 12/31/94 100% Sample Dt Sam ple# D uration Type Employee Mama BTO: 08 LO C: 113 TEFLON P /S - SHIFT MECHANIC (58MD) 2/2/94 19405 360 P 5/17/94 19813 390 P 8/26/94 20160 360 P 12/13/94 20672 380 P Pere Chemical 5BMD C-8/FC-143 5BMD C-8/FC-143 58MD C-SZFC-143 58MD C-8/FC-143 BTO: 08 TEFLON LOG: 703 FINE POWDER PACKOUT ROOM 1/27/94 19338 370 P 08PJ C-8/FC-143 BTO: 08 LOC : 708 TEFLON P /S - FINE POWDER PACKOUT (06PJ) 1/27/94 2546 375 A 8/25/94 20153 390 P C-8/FC-143 08PJ C-8/FC-143 BTO: 08 LOC: 717 TEFLON ROOF AREA-GENERAL 1/28/94 8 8 380 A C-8/FC-143 BTO: 08 LO C: 731 TEFLON A /S -INSIDE F.P.

AR226-2188 ,3 Debbie J Mulrooney ' 08/23/2001 09:53 A M To: cc: Subject Chris E Shoop/AE/DuPont@DuPont Question on Source Spreadsheet Chris, I noticed that on the revised spreadsheet you added a column showing the fraction of P M that is C8.

AR226-2189 Chris E Shoop 08/24/2001 03:59 PM To: Debbie J Mulrooney/AEA)uPont@ DuPont cc: Roger J Zipfe!

AR226-2234 Steven L Grise 12/12/2001 03:26:26 PM To: Debbie J Mulrooney/AE/DuPont@DuPont cc: Bernard J Reilly/AE/DuPont@DuPont, Robert F Pinchot/DEV/AE/DuPont@DuPont Subject: Re: C.O.

Katherine E.

AR226-3355 PHYSICOCHEMICAL PROPERTIES Or FLUOROTELOMER ALCOHOLS M ary A Kaiser ttryi P Cabranchi,3 Chien-Ping Chai K a o / Pan!

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