*6pf AR226 _ [0 3 EPA / SPI FMG Meeting January 30,2002 Agenda Introduction = Toxicology/PK Program Studies underway Progress o Time line = Ed 3 Environmental Effects/Fate Testing program * Environmental distribution Summary | PROJECT SUMMARY REF: APFO -2 SPONSOR (AsahiAGPlMasEs,PDTuFPEonCto,mDmyintetoene,MDeamikbienr,sAuasnidmAonPtF,OSoSluvpapyl,ieArtsoFina 3M, Miteni) CHEMICAL sTUDY Ammonium Perfluoro-octanoate (APFO~ FC143) Preliminary 4 week oral toxicity study in Cynomolgus monkeys. 6 month oral toxicity study in Cynomolgus monkeys to include an additional 13 week recovery period PURPOSE To understand the particular, to study toxicity of APFO in the effects on the liver, a on sub-human pancreatic primate. function, In on| homone levels administered dose and and to understand APFO levels in the body relationship between fluids (eg plasma) and tissues.

Ar226 -- 1109 SELECTED FLUOROCHEMICALS IN THE DECATUR, ALABAMA AREA e 22 =z 3258 2=R - CONTAIN NO CB!

- 226 US] ntTT - ANALYSIS OF ENDOGENOUS FLUORSOCtHEuMdICyALSTiINtNlOeRMAL POOLED HUMAN SERUM AND PLASIA - Data40RCeFqR uPairtr7e62ment - Author Mark E.

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3M Specialty Materials 3M Center St.

BACK TO MAIN ACUTE ORAL TOXICITY TO TERRESTRIAL INVERTEBRATES (HONEY BEE) TEST SUBSTANCE Identity: Perfluorooctanesulfonate; may also be referred to as PFOS or FC-95. (1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-, potassium salt, CAS # 2795-39-3) Remarks field: The 3M production lot number was 217.

02/28/2001 ~ ~ ENVIRONMENTAL LABORATORY ARCHIVED FINAL REPORT B1ACK TO MAIN LAB REQUEST NO. 8442 REQUESTOR NAME: EAR DEPARTMENT: 0535 PROJECT NO: 9970012600 DATE RECEIVED: 0 9 / 0 7 / 1 9 8 2 DESC: ENVIRONMENTAL SCREEN ON L-6778 CONTRACT LAB(S): EXP COMP DATE: 11/12/1982 DATE COMPLETED: 1 1 / 0 9 / 1 9 8 2 PROJECT LEAD: PHONE NO: 3M FAX NO: 651-778-6176 EVAPORATE TO DRYNESS UNDER AIR OR N2.

PERFLUOROOCTANESULFONATE, POTASSIUM SALT (PFOS): A 96-HOUR STATIC ACUTE TOXICITY TEST WITH THE RAINBOW TROUT (Oncorhynchusmykiss) FINAL REPORT WILDLIFE INTERNATIONAL, LTD.

TITLE: SAMPLE TRACKING OF WILDLIFE SAMPLES ANALYZED FOR CONCENTRATIONS OF PERFLUO BY: John L.

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AR226-2106 Test Results Sample Date Range Concentration Range Action Level Industrial Hygiene lfl/79 1231/79 100% Sample Dt Sample?

AR226-2290 Chris E Shoop 09/05/2002 02:32 PM To: cc: Subject: Debbie J Mulrooney/AE/DuPontQDuPont, wevociaur@comcast.net Robert F Pinchot/DEV/AE/DuPont@DuPont, Karl G Kronberg/AE/DuPontQDuPont, Ta-Wei Fu/SE/DuPontQDuPont, Robert L Ritchey/CL/DuPontQDuPont Stacks & Emissions tor Current and 2003 Modeling Debbie / Bob, Please see the attached sheet named Stacks & Surfactant Emissions- 12c.zip for 2001,2002, and 2003 emission estimates.

AR226-2577 j'AndFewS'HarttBn ----:-- "^ ----------01/31/2002 O'^SSTVn To: cc; Subject: M.

AR226-2587 Division of Water Resources 1201 Greenbrier Street Charleston, WV 2531)-1108 304-558-2108 Fax: 304-558-2780 West Virginia Department of Environmental Protection Bob Wise Governor 3 July 2002 Miehtel 0.