FILE NAME DuPont DUP DATE 2006 Apr 13 DOC DUP304 DOCUMENT DESCRIPTION Legal - Affidavit of Barry Castleman NO 01843 MILDRED LEE INDIVIDUALLY AND AS EXECUTRIX EXECUTRIX OF THE ESTATE OF DUEL LEE E.I.

FILE NAME Brakes BRK DATE 2009 DOC BRK204 DOCUMENT DESCRIPTION Journal Article - Occupational Domestic and Environmental Mesothelioma Risks in the British Population British Journal of Cancer 2009 100 1175-1183 '2009 Cancer Research UK All nights reserved 0007 0920/09 32.00 mpg ww.bjcancer.com www.bjcancer.com re Occupational domestic and environmental mesothelioma risks in the British population a control study C Rake C Gilham J Hatch A DarntonJ Hodgsonand J Peto Institute of Cancer Research Sutton Surrey SM2 5NG UK Epidemiology Unit Health and Department of Epidemiology and Population Health London School Safety Executive Bootle Merseyside L20 3QZ UK 7HT UK of Hygiene and Tropical Medicine London University Keppel Street London WCIE We obtained lifetime occupational and residential histories by telephone interview with 622 110 women and 1420 population controls Odds ratios mesothelioma patients 512 men 1940s Male ORs ORs were converted to lifetime risk LR estimates for Britons bom in the 95 confidence interval CI relative to lowrisk occupations for > 10 of years were 50.0 25.8-96.8 for carpenters LR in 17 years exposure 17.1 10.3-28.3 for plumbers electricians before the age of 30 other construction workers 15.3 9.0-26.2 for other recognised and painters 7.0 3.2-15.2 for asbestos be recognised high occupations and 5.2 3.1-8.5 3.1-8.5 in other industries where may encountered The LR was similar in apparentlyapparently apparently unexposed men and women ~ 1 in 1000 and this approximately doubled in exposed workers relatives OR 2.0 95 % CI 1.3-3.2 No other environmental hazards was identified In all 14 of male and 62 of female cases were not attributable to occupational or domestic asbestos were of the male cases were construction workers and only four had workedworked for more than 5 exposure Approximately half British Joumal of Cancer 2009 100 1175-1183 doi 10.1038 years in asbestos product manufacture ~ Published online 3 March 2009 sj.bjc.6604879 www.bjcancer.com '2009 Cancer Research UK Keywords mesothelioma control amosite The British mesothelioma death rate is now the highest in the world with 1749 deaths in men 1 in 40 of all male cancer deaths below 80 years of age and 288 in women in 2005.

`SEP. 13.2004 2:58PM RWDM LAW FIRM Multi-Pagettf NO. 653 P. 6 Page 14 Page 16 l A.

PREREQUISITE REVIEW 21.

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THERAPY IN PRACTICE Am J Cancer 2006; 5 (2): 81-91 1175-6357/06/0002-0081/$39.95/0 2006 Adis Data Information BV.

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