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Chemico-Biological Interactions 183 (2010) 133141 Contents lists available at ScienceDirect Chemico-Biological Interactions journal homepage: www.elsevier.com/locate/chembioint XJW20, a novel oxoindole derivative, induces G2/M arrest and apoptosis selectively in K562 leukemia cell line Ziqi Ye a,c, Zhe Chen a, Wenteng Chen b, Jinwen Xie b, Hongyu Yang a, Yijia Lou a,, Yongping Yu b, a Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, Zhejiang University, Hangzhou, 310058, China b Institute of Materia Medica, Zhejiang University, Hangzhou, 310058, China c Department of Pharmacy, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China article info Article history: Received 15 September 2009 Received in revised form 20 October 2009 Accepted 20 October 2009 Available online 31 October 2009 Keywords: Oxoindole derivate Antitumor K562 cell line G2/M arrest Apoptosis Mitochondrial transmembrane potential abstract In comparison with four tumor cell lines and three non transformed cell types, chronic myeloid leukemia K562 cells were selectively sensitive to proliferation inhibition by the oxoindole derivative XJW20, as determined by the MTT assay.

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