DISCUSSION The data offer a reasonable support to our hypothesis that the pathogenesis of vinyl chloride intoxication includes a "trigger ing mechanism" of the toxic effect as well as its development, leading to characteristic clinical manifestations.

LEAD MERCURY CADMIUM i/j 9 1 1;_ P AOS i HE)<.

Figure 1 shows the pathways of reductive dehalogenation which lead to the biotransformation of the common chlorinated solvent perchloroethylene (PCE or tetrachloroethylene) under methanogenic conditions.

New topics Doped- aluminas(DP/TGG) Report on encapsulation of lead chromate(TGG) Review PVC rat study(TGG/DP) 10.

I am following the trail of new evi dence and new thinking about environ mentalism wherever it leads.

CHEMICAL MANUFACTURERSASSOCIATION July 8, 1992 To: Ethylene Dichloride Panel Members Re: Follow-Up Items from June 29th Conference Call There were several issues raised during the June 29th EDC Panel conference call which I agreed to address.

Relative Toxicity of Lead and Some of Its Com mon Compounds Lawrence T.

Lead leached from soldered copper joints far exceeded then current and proposed EPA standards for lead in drinking water.

Also, focus on long lead items.

Relative Toxicity of Lead and Some of Its Com mon Compounds Lawrence T.

., suggested that talc application directly to the genital area around the time of ovulation might lead to talc particles becoming deeply imbedded in the substance of the ovary and perhaps causing foreign body reaction (granulomas) capable of causing growth of epithelial ovarian tissue.1517 Harlow, et al., found that frequent talc use directly on the 9 Cralley LJ, Key MM, Grotti DH, Lainhart WS, Ligo RM.

DISCUSSION The data offer, a reasonable support to our hypothesis,that' the pathogenesis of vinyl chloride intoxication includes a "trigger ing mechanism" of the toxic effect as well as its development, leading to characteristic clinical manifestations.

VCM condensation in lines leading to the railcar unloading compressors is suspected of causing fugitive VCM emissions at the compressors.

EPA Ca1h^ii000ll54ll4 i 4- - A Assessment Group found that alternative plausible modeling assumptions would lead to risk estimates that were 15-fold to 10,000-fold lower than the standard LMS procedure.

We would have expected to receive at least standard directories (including data audit trails) and coding As you probably know, re-creating documentation is time consuming, and may lead to errors.