A REVIEW AND EVALUATION OF CARCINOGENICITY STUDIES IN MICE AND RATS AND MUTAGENICITY STUDIES WITH POLYCHLORINATED BIPHENYLS \ George J.

1 the proper interpretation of the results ate still* key ingr. dients in the evaluation step. 1 he possibility ol "tal'C neg. live" decisions leading to erroneous assumptions ol sale: , or "false positive" conclusions leading to unwarranted expenditures of resources lor controls, still exists legardles.

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The concepts r proper selection of workers at risk: the understanding e limitations, interferences and similar factors, and v.ltimatel the proper interpretation of the results ate still key ingre dients in the evaluation step. 1 he possibility ol "lake nog; But while mosl evaluation techniques were reaching the live"decisions leading to erroneous assumptions ol salety ) point where the industrial hygiene staff required thcaddition or "false positive" conclusions leading to unwarrante of someone with a Ph D. in electrical engineering, a new expenditures of resources lor conii ok still exists iegardle" device has appeared which has the key of simplicity -- ihe of the measurement device used.

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Bell Helicopter INTER-OFFICE MEMO August 22, 1989 MEMO TO: SUBJECT: All Employees PERSONAL PROTECTIVE EQUIPMENT > The safety and health of employees and the prevention of injuries and illnesses are prime objectives of Bell Helicopter management.

IN THE UNITED STATES COURT OF APPEALS FOR THE DISTRICT OF COLUMBIA CIRCUIT ORAL ARGUMENT SCHEDULED FOR JANUARY 31, 1989 Nos. 88-1531 gi al.

DRAFT DO NOT CITE OR QUOTE EPA/600/R-11/005A January 2013 External Review Draft Update to An Inventory of Sources and Environmental Releases of Dioxin-Like Compounds in the United States for the Years 1987, 1995, and 2000 NOTICE THIS DOCUMENT IS AN EXTERNAL REVIEW DRAFT.

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., Shawmigan), thorough inves tigations were conducted, leading to precise diagnoses.

DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service PCB-ARCH-EXT0378747 Contents Page Executive Summary 1 Introduction 5 Substances or groups of substances, and technological or manufacturing processes that are Known to be carcinogenic: 4-Aminobiphenyl 10 Arsenic and certain arsenic compounds . 22 Asbestos 24 Aurarnine manufacture 26 Benzene 28 Benzidine 30 N,N-bis(2-chloroethyl)-2-naphthylamine (chlornaphazine) 34 Bis(chloromethyl)ether (BCME) and technical grade chloromethyl methyl ether (CMME) 35 Chlorambucil 39 Chromium and certain chromiumcompounds 41 Coke oven emissions 42 Cyclophosphamide 45 Diethylstilbestrol (DES) 60 Hematite underground mining 73 Isopropyl alcohol manufacture (strong-acid process) 79 Melphalan 04 Mustard gas 00 2-Naphthylamine 09 Nickel refining 90 Soots, tars, and mineral oils n9 Thorium dioxide 124 Vinyl chloride 132 Substances or groups of substances that may reasonably be anticipated to be carcinogens: 2-Acetylaminofluorene 14 Acrylonitrile 14 Aflatoxins 16 2-Aminoanthraqumone 17 1 -Amino-2-methylanlhraquinone 10 Amitrole 20- o-Anisidine and o-anisidine hydrochloride 20 Aramite 2i Benz(a)anthracene 2/ Benzo(b)fluoranthene 3' Benzo(a)pyrene ' . 5t n~r, >* ^ ' *nin "* I " r*v'\t PCB-ARCH-EXT0378748 Cadmium and certain cadmium compounds Carbon tetrachloride Chloroform p-Cresidine Cupferron Cycasin 2.4-Diaminoanisole sulfate 2.4- Diaminotoluene Dibenz(a.h)acridine pibenz(a,j)acridine Dibenz(a,h)anthracene 7H-Dibenzo(c,g)carbazole Dibenzo(a,h)pyrene Dibenzo(a,i)pyrene 1.2-Dibromo-3-chloropropane (DBCP) 1.2-Dibromoethane (EDB) 3,3'-Dichlorobenzidine 1.2- Dichloroethane (EDC) Diepoxybutane Di(2-ethylhexyl)phthalate 3,3' -Dimethoxybenzidine 4-Dimethylaminoazobenzene 3,3'-Dimethylbenzidine Dimethylcarbamoyl chloride Dimethyl sulfate 1.4- Dioxane Direct Black 38 Direct Blue 6 Ethylene thiourea Formaldehyde Hexachlorobenzene Hydrazine and hydrazine sulfate Hydrazobenzene lndeno(1,2,3-cd)pyrene Iron dextran complex Kepone (chlordecone) Lead acetate and lead phosphate Lindane and other hexachlorocyclohexane isomers 4,4'-Methylenebis(2-chloroaniline) (MOCA) 4,4'-Methylenebis(n.n,-dimethyl)benzenamine Michler's ketone Mirex Nickel and certain nickel compounds Nitrilotriacetic acid 5-Nitro-o-anisidine Page 36 38 40 43 44 45 46 47 48 49 50 51 51 52 53 54 55 57 58 58 61 62 63 64 65 66 67 69 70 71 74 75 77 78 78 80 81 82 84 86 87 88 90 91 92 Nitrofen N-Nitrosodi-n-butylamine N-Nitrosodiethanolamine N-Nitrosodiethylamine N-Nitrosodimethylamine p-Nitrosodiphenylamine N-Nitrosodi-n-propylamine N-Nitroso-n-ethylurea N-Nitroso-n-methylurea N-Nitrosomethylvinylamine N-Nitrosomorpholine N-Nijrosonornicotine N-Nitrosopiperidine N-Nitrosopyrrolidine N-Nitrososarcosine Oxymetholone Phenacetin Phenazopyridine and phenazopyridine hydrochloride Phenytoin and sodium salt of pher ytoin Polybrominated biphenyls (PBBs) Polychlorinated biphenyls (PCBs) Procarbazine and procarbazine hydrochloride p-Propiolactone Reserpine Saccharin Safrole Selenium sulfide Streptozotocin Sulfallate 2,3,7,8-Ietrachlorodibenzo-p-dioxin (TCDD) Thioacetamide Thiourea o-Toluidine and o-toluidine hydrochloride Toxaphene 2,4,6- Trichlorophenol Tris(1-aziridinyl)phosphine sulfide Tris(2,3-dibromopropyl)phosphate Urethane Index "** Acronyms and Abbreviations Units of Measurement Page 94 95 96 97 98 99 100 101 101 102 103 103 104 105 106 107 108 108 109 110 111 113 114 114 115 117 117 120 120 121 122 123 125 126 127 129 129 130 138 134 Agents in italics are new to this Report PCB-ARCH-EXT0378749 Copies of this Report summary may be obtained from the Public Informa tion Office.

8 Corporate Research, 4008F-80 Corp.

9 120 121 122 123 1 el A 125 126 127 123 129 130 131 1 32 133 134 135 p ig me n t s MATERIAL MATERIAL C0DE DESCRIPTION BVIOO NVV0L NVWT GAL PCT PCT COST 1 LB *R498 *2500 *R 503 *R509 +R513 *R 546 *R 543 *R565 *2 566 *3 370 *r<6i i *fn:20 :VR 661 *fl 663 *2 710 *8 734 *8735 *WU2 *WU7 W134 +W137 *W138 *W452 *W514 *W533 *W545 *V)547 *W617 *W624 *W625 *W737 *W749 *W 7 5 5 *W784 *VJ320 *1/822 *W830 *W926 -W943 *W944 *W948 *W95 l REC-0X-R7O98 2.33 XRPF1A-R0-3O97 2.43 KRGMA-R0-8O97 2.5 UFA -0XIDE 8*33 REf -FE-0X 2*33 PRG {JND-FE-0RE 2.62 PEF-GULF-FE-0X 2.77 REl-LEAD-95 HEf -LEAD-97 PB"SI-CR-M50 1.34 1.34 2.93 M0J ACC0-MAR00N 6.25 R0NAN-RED-1082 7.15 GA':.NET-T0NF.R 7.79 MACATAWA-RED 7.64 miJIDINE-T0N 8.28 CLl-NITRAN-RKD 8.08 Xi13l"NIP~T0NER 7.35 UTH0P0NE LiTItflPONE 2.79 2.79 T1TAN0X-RC 3.69 h c a l -r c h t x 1 ICAL-RCKT 3.69 3.69 1SADED-Z1NC-123 8.13 1AD0X-515 7N0--427W 2.14 2,12 2INC-0X-417W ZN0-EP414 2.14 2.14 TITAilOX-AMP u p u r e -l v i 3.16 3,07 Z0PAQUE-LDC Z0PAQUE-R 77$ 3.07 3.07 Z0PAQUE-R99 2.9 ZOPAOUE-R 55 2.88 1102-VINYL 4.23 Z0PAQUE-R83 2.9 TIPURE-R610 2.86 Z0PAQUE-RS8S 2.91 DUP0NT-R103 3.02 Z0PAQUE-RCL-9 T1PURE-R900 2.92 2.92 DUP0NTR-96O 3.04 Z0PAQUE-RCL-7 2.99 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100,0 100.0 100,0 100,0 100,0 100,0 100.0 100.0 100.0 100,0 100.0 100.0 100,0 100,0 100,0 100.0 100.0 100.0 100.0 100.0 100,0 100.0 100,0 100,0 100.0 100.0 100,0 100.0 100.0 100.0 100.0 100.0 100,0 100.0 100,0 0.182 R 100.0 0.1769 n 100,0 0.1769 R 100,0 0.1728 R 100,0 0*1576 R 100.0 0.0479 R 100,0 0.1179 R 100,0 0.1871 R 100.0 0,1911 R 100,0 0.2231 R 100,0 2.326 R 100.0 2.1455 R 100.0 1.4825 R 100,0 1.9415 R 100,0 1.5687 R 100.0 1.5335 R 100*0 1.68 R 100,0 0.1106 R 100,0 0.108 R 100*0 0.0981 R 100.0 0.0956 R 100,0 0.0956 R 100.0 0,1474 R 100.0 0.1769 R 100,0 0.159 R 100,0 0.159 R 100.0 0.1576 R 100.0 0.159 R 100.0 0,2307 R 100.0 0.2687 R 100.0 0.2891 R 100,0 0,2862 R 100.0 0,2891 R 100.0 0.6002 R 100.0 0.2789 R 100,0 0.3044 R 100.0 0.2891 R 100.0 0.2888 C 100.0 0.2687 R 100.0 0.2891 n 100.0 , 0.291 c. 100.0 0.29 0 C0ST 1 GAL 7,81 7.28 7.08 7.42 6,76 1*83 4.26 13.96 14.26 7,61 37.22 30.01 19.03 25,41 18.95 18,98 22.86 3.96 3.87 2.66 2.59 2.59 6.92 8.27 7.5 7,43 7.36 5,03 7,51 8.75 9,42 9,87 10.04 24.19 9,62 10.64 9*93 9.56 9.2 9.9 9.57 9.7 GLD005269 / / 4 - 04/15/69 m 9>* w* r0- t* m o >rv m r ****** i 0LVENTS ** ** et m ** * **** 9* mr~ mti mm C0MP MATERIAL MATERIAL C0DE C0DK DESCRIPTION ~ ~ -- - .r. r, .* * VI / '1VV0L NVYJT COST GAL POT rcT 0*> Ws 1 LB C0ST 1 GAL art *f% * 136 <H>*S2I3 137 CH) S222 138 S231 139 +S232 MO S330 l 41 CH) S332 M2 S343 M3 S353 144 S335 1 45 CH) S 416 146 S423 l 47 S438 M3 S446 149 S 460 150 *S554 151 *S 556 152 S 558 153 CH) S370 154 S3 72 155 CH) S574 156 *S 5 7 7 157 *$ 390 153 CH) S612 159 (H ) S 6 M 160 S 622 161 +S626 162 *S651 163 S7U 164 S7M 165 $731 166 DEN-ALCPHAL ISOPROPYL-AL N-BUT-AL TRIDECYL-Al.

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