The neurotoxic effects of MPTP4 (lmethyl-4-phenyl-1,2,3,6-tetrahydropyridine), which ultimately lead to a clinical picture of parkinsonism in humans and other primates (l), require its metabolic 1This work was supported by the Odd Fellows Lodge, Stockholm, Sweden (G.E.), the Health Effects Component of University of California Toxic Sub- stances Program (D.D.), the Northern California Oc- cupational Health Center (M.S.S.), and the National Foundation for Cancer Research (M.T.S

ST009I6I3 MINIMUM REQUIREMENTS THE DOW CHEMICAL COMPANY APRIL 1984 3RD EDITION ST0091614 These Minimum Requirements for Safety.

.| i zinc ,2m i None None lead (phi i None , thai lKJM(th i None CHROMIUM-HEX (Cf +6)1 NOne 1 1.................... 1

-NOT OXIDE TITANIUM DIOXIDE TOLUENE TOTAL OXIDANTS AS OZONE TRANS--X,2D1CHLOROETHYLENE TRICHLOROETHYLENE TRIORTHOCRESYL PHOSPHATE TURPENTINE UNSYM-TETRACHLOROETHANE VINYL ACETATE VINYL BROMIDE VINYL CHLORIDE VINYL TOLUENE VINYLIDENE CHLORIDE MELDING FUME-TOTAL X-RADIATION XYLENE ZINC CHLORIDE FUME ZINC OXIDE FUME ZINC STEARATE 1,1 DICHLOROETHANE S 1,1 DIMETHYLHYDRAZ1NE S 1,1,2 TRICHLOROETHANE 1,2-BUTYLENE OXIDE 1,2,3--TRICHLOROBENZENE 1,2,A--TRI CHLOROBENZENE 1,3--BUTADIENE 1,3--DIOXOLANE C 2--NITROPROPANE 2,6 DITERTBUTYL-P-CRESOL Anthophyl1ite Actinolite TremolIte Biphenyl Cyclohexyl Amine Diethanolamine Diethy1enetriamine Ethanol amine Formaldehyde THF TIN--IN T102 TOLUEN TOT-OX TRANS TRI TOCP TURPEN UNSYM V-ACET VBR VCM VTOL VDC MELDFU X-RAYS XYLENE ZNCLFU ZNOF ZNSTER DCE DMEHYZ TCE BLM 123TCB TCB BUDIEN DOL 2-NPRO DTBPC ANT ACT TRE Biphen Cyhxam Dietam Detram Ethamn Formal 200 2 10 100 0.1 10 50 0.1 100 5 10 1 1 50 2.5 5 VAR 100 1 5 10 10 0.5 10 5 N/A N/A 250 25 N/A 10 0.2 0.2 0.2 0.2 10 3 1 3 1 (TLV > ( TLV > (TLV ) (TLV ) (IPEL) (IPEL) (TLV ) (TLV > (TLV > (IPEL) (TLV ) (IPEL) (OSHA) (TLV ) (IPEL) (TLV ) (TLV ) (TLV ) (TLV ) (TLV ) (TLV ) (IPEL) (TLV ) (TLV ) (IPEL) () () (IPEL) (IPEL) () (TLV ) (OSHA) (OSHA) (OSHA) (TLV ) (TLV ) (TLV ) (TLV ) (TLV ) (TLV ) 250 (TLV > 4 (TLV ) 20 (TLV ) 150 (TLV ) 0.3 (IPEL) 25 (IPEL) 200 (TLV ) 0.3 (TLV ) 150 (TLV ) 10 (IPEL) 20 (TLV ) 5 (IPEL) 5 (OSHA) 100 (TLV ) 10 (IPEL) 10 (IPEL) VAR (TLV ) 150 (TLV ) 2 (TLV ) 10 (TLV ) 10 (TLV ) 25 (IPEL) 1 (TLV ) 20 (TLV ) 10 (IPEL) N/A ( ) 5 (TLV ) 375 (IPEL) 50 (IPEL) 25 (TLV ) 20 (TLV ) () () () 0.6 (TLV ) () () () 6 (TLV ) 2 (TLV ) PPM MCM MCM PPM PPM PPM PPM MCM PPM PPM PPM PPM PPM PPM PPM MCM OTH PPM MCM MCM MCM PPM PPM PPM PPM PPM PPM PPM PPM PPM MCM FML FML FML PPM PPM PPM PPM PPM PPM INTERNAL PERMISSIBLE EXPOSURE LIMITS (IPELS) 08/19/86 CHEMICAL NAME CODE TWA SOURCE STEL SOURCE UNITS N-PROPYL CHLOROFORMATE NICKEL METAL NITRIC ACID NITRIC OXIDE c NITROGEN DIOXIDE NITROMETHANE NOISE NORM.BUTYL ACETATE NUISANCE DUST NUISANCE DUST-RESPIRABLE c ORTHO-DICHLORBENZENE OXALIC ACID OZONE PALLADIUM PARA-DICHLOROBENZENE s PENTACHLOROPHENQL PERCNLOROETHYLENE s PHENOL PHOSGENE PHOSPHORIC ACID PLATINUM s POLYCHLOR BIPHENYLS 42%CL s POLYCHLOR BIPHENYLS 54XCL c POTASSIUM HYDROXIDE PPG 1013 s PROPARGL ALCOHOL PROPYLENE TRICHLORIDE PYRIDINE RUTHENIUM SEC-BUTYL ALCOHOL SEC-BUTYL CHLOROFORMATE SILICON CARBIDE SILVER METAL SOLUBLE CMPD c SODIUM AZIDE c SODIUM HYDROXIDE STODDARD SOLVENT STYRENE MONOMER SUCROSE SULFUR CHLORIDE SULFUR DIOXIDE SULFURIC ACID s SYM-TETRACHLOROETHANE SYN PRECIP SILICA--RESP SYN PRECIP SILICA-TOTAL TANTALUM c TERPHENYLS TERT-BUTYL ALCOHOL NPCF NICKEL HN03 NO N02 NITMET NOISE NBA DUSTNU DUSTNR ODCB OXACD 03 PALLAD PDCB PCP PER PHENOL PHOSGC HP 03 PT PCB-42 PCB-54 KOH 1013 PRGOH PTCL2 PYRDIN RUTH BU2ALC SBCF SIC AG NAN3 NAOH 8TDSOL STYREN 6UCROS S2CL2 S02 H2S04 SYM SPS-R AM--S1L TA TERPH BUOH-T 1 (IPEL) 1 (TLV ) 2 (TLV ) 25 C TLV ) 3 (TLV ) 100 (TLV ) 90 (OSHA) ISO (TLV ) 10 (TLV ) 5 (TLV ) N/A ( ) 1 (TLV > 0.1 (TLV ) 0.1 (IPEL) 75 (TLV ) 0.5 (TLV ) 50 (TLV > 5 (TLV ) 0.1 (TLV ) 1 (TLV ) 1 (TLV ) 1 (TLV ) 0.5 (TLV ) N/A ( ) N/A ( ) 1 (TLV ) 5 (IPEL) 5 (TLV ) N/A ( ) 100 (TLV ) N/A ( ) 10 (TLV ) 0.01 (OSHA) N/A ( > N/A ( ) 100 (TLV > 50 (TLV ) 10 (TLV > 1 (TLV ) 2 (TLV ) 1 (TLV ) 1 (TLV > 5 (IPEL) 10 (TLV ) 5 (TLV ) N/A ( ) 100 (TLV ) 5 (IPEL) N/A ( ) 4 (TLV ) 35 (TLV ) 5 (OSHA) 150 (TLV ) N/A ( ) 200 (TLV ) N/A ( ) N/A ( ) 50 (TLV ) 2 (TLV ) 0.3 (TLV ) 0.3 (IPEL) 110 (IPEL) 1.5 (TLV ) 100 (IPEL) 10 (TLV ) 0.3 (IPEL) 3 (TLV ) N/A ( ) 2 (TLV ) 1 (TLV ) 2 (TLV ) N/A ( > 3 (TLV ) 10 (IPEL) 10 (TLV > N/A ( ) 150 (TLV ) N/A ( ) 20 (TLV ) N/A ( ) 0.1 (TLV ) 2 (TLV ) 200 (TLV ) 100 (TLV ) 20 (TLV ) 3 (TLV ) 5 (TLV ) 2 (IPEL) 5 (TLV ) N/A ( ) N/A ( ) 10 (TLV ) 0.5 (TLV ) 150 (TLV ) PPM MCM PPM PPM PPM PPM OTH PPM MCM MCM PPM MCM PPM MCM PPM MCM PPM PPM PPM MCM MCM MCM MCM MCM UCM PPM PPM PPM MCM PPM PPM MCM MCM PPM MCM PPM PPM MCM PPM PPM MCM PPM MCM MCM MCM PPM PPM INTERNAL PERMISSIBLE EXPOSURE LIMITS (IPELS) 08/19/86 CHEMICAL NAME CODE TUA SOURCE STEL SOURCE UNITS FLUORIDE AS F C FREON 8 FURFURyL ALCOHOL GLYCIDOL (EPOXYPROPANOL> GRAPHITE HEXACHLOROETHANE C HYDROGEN CHLORIDE (ACID) HYDROGEN FLUORIDE HYDROGEN PEROXIDE HYDROGEN SULFIDE HYDROQUINONE C IODINE IRON OXIDE FUME ISOBUTANOL ISOBUTYLCHLOROFORMATE C ISOPHORONE ISOPROPYL ACETATE ISOPROPYL ALCOHOL ISOPROPYL CARBANILATE ISOPROPYL CHLOROFORMATE ISOPROPYL PERCARBONATE s LEAD-ORGANIC LEAD-PARTICULATE LIQUIFIED PETROLEUM GAS M-DICHLOROBENZENE s M-ETHYLGLYCOL M-METHYL ET MANGANESE FUME s MERCURY s METHANOL C METHBISCYCLOHEXISOCYANATE METHYL CHLORIDE METHYL CHLOROFORM METHYL CHLOROFORMATE METHYL CYCLOHEXANE METHYL ETHYL KETONE METHYL ISOBU KETONE s METHYL ISOCYANATE c METHYL MERCAPTAN s ME T HYL CYCL OP N-D-MN-T RICB L METHYLENE CHLORIDE MOLYBDENUM MONO-CHLOROBENZENE MONOCHLOROACETYLENE C N-BUTANOL N-HEPTANE N-HEXANE s N-PROPANOL FLORID FREON FURALC GLYCDL GRAPHT HEX HCL HF H202 H2S HQ 12 FEOXFU IBL IBCF ISOPHO IPRACT ISOALC IPC IPCF IPP PBORG PBPART LPG MDCB MEGE MANGFU HG METHOL HYLENE ME CL MC MCF MECYHX MEK .

SECTION V - HEALTH HAZARO DATA EFFECTS OF OVEREXPOSURE-ACUTE 6 CHRONIC: 1 N GE S" CN -THIS MATERIAL CONTAINS LEAD WHICH MAY RESULT IN LONG-TERM EFFECTS.

All patients had a normal 12-lead ECG.

U Contract No.

Diffuse pleural thickening is sometimes seen and in rare cases can lead to impairment of lung function.

INSTITUTFOR PHARMAKOLOGIE UND TOXIKOLOGIE DER UNIVERSITAT WURZBURG Yorstand: Prof L>- D.

Evans, OAQPS VC Lead Engineer TRW James W.

As it is known that silicadust exposure leads to lung dysfunction of an obstruct

These studies reinforce the facts that nominal short fibre preparations may lead to retention of long fibres in the lung, even when the long fibres make up only a small fraction of the initial aerosol, and that electron microscopic counting and sizing of fibres in both aerosol and tissues are needed to optimally interpret fibre clearance data.

But are focusing on the biodistribution of the overall numbers have changed little there are many types of white blood intravenously administered antibodies during the past 40 years: Cancer re cells and, therefore, many types of leu to develop techniques that reduce their mains the second leading cause of death kemia, each of which can behave differ nonspecific distribution in the body.

Vista Chemical Company 15990 North Barkers Landing Road Post Office Box 19029 Houston, Texas 77224 Phone (713) 531-3200 January 21, 1988 Reynolds Metals Company ATTN: Industrial Hygiene 6603 West Broad Street Richmond, VA 23230 V1S1A Dear Mr.

The presence cf tremolite in chrysotile shoxild be regarded as ubiquitous, even to very small quantities, because the paxagenesis cf these minerals, which ay-lies also tc vermicv.lite and talc, leads to such a conclusion, as explained later.