It is an extremely ra re c a n c e r fa the general papulation sand is almost to variably easodated with asbestos exposure, It is a rapidly progressive disease; leading to death within a year or two of appearance.

Acute Effects: The initial symp toms of exposure are laenmation, salivation, and irritation of the nose and throat; continued exposure can lead to nausea, vomiting, and narcosis: Also, low blood pressure and cardiac rhythm abnormalities; respiratory depression; nausea, vomiting, bums of the esophagus, and diarrhea; and anesthesia with dizziness leading to loss of consciousness and coma; plus possible transient liver and kidney changes.

The asbestos experience and the introduction of controls would lead to the control of more and more toxic substances with the objective of allowing no more human experiments on a grand scale.

For example, since at least one case was exposed to each of nearly 200 chemicals, chance alone should lead to identification of about 10 chemicals whose proportion is significantly different between ceses end controls.

The 88 substances oo the list are: 2-Acetylambkofluorene Acrylonitrile Aliatoxins 4-Aminobipheoyl Amitrole Aramite Arsenic and compounds Asbestos Auramine, manufacture of Benz(a)anthraceoe S-12-S2 Canted Reputeson nuorw O14S-7m/2/*MJ0 1268 CHEMICAL REGULATION REPORTER Bagaac Benzidine Denxo(b)fluorantheoc and benzo(j)ftiioranthene Benzo<a)pyrene Beryllium and compounds N,N-Bia(2-chloroethyl}-l-naphthylamine Bia(chloromethyl) ether end chlorocnethyl methyl ether Cadmium and certain compounds Carbon tetrachloride Chlorambucil Chloroform Chromium and compounds Coke oven emissions p-Cresidine Cjcasin Cyclophosphamide 2.4- Diamiootoluene Dibenz(aji)acridine Dlbenz(aJ)acrldine IMtwu(aJi)anthracene 7B-Dibenxo(c,g)carbaiolc Dibenio(aJi)pyrene Dibenao(a4)pyrene lJ-Dibromo-3-chloropropaDe 1,2-Dibromoethane Dlchlorobefaxldine lJ-Dtchkroethane Diethylstilbestrot Dimethyl carbamoyl chloride Dimethyl sulfate 1.4- Dtoxane Pormaldefayde underground mining Hydraaoberaene Indeno(lJ,a-cd)pyrene Iron dextrin Isopropyl alcohol manufacture using strong add procees Kepone Lead acetate and lead phosphate IJurian* mnA nthmr KrrlilfrftPypM>wn lMf MIpAalnii Mirex Mustard gas 2-NaphthyUmine Nickel r^nlng and certain compounds N-Nftroeodi-N-butyiamine N-NitroeodiethanoUmine N'Nltroaodiethylamine N-NitroeodimethyUinine N-Nltroeodi-N-propylamiiie N-Nltroso-N-etbyiorea N-Nltroso-N-methylorea N*Nltroaomethyi vinylamlne N-Nitroaomorpholine N-NitzoeoQaniicotine N-Nitrosopiperidine N-Nitrosopyrrolidine N-Nitrooosarcoeine Oxymethahme Pbenacetin Phenasopyridine hydrochloride Phanytoin Polychlorinated biphenyls ProcarbasiDe and procarbazine hydrochloride 0-PropioUctooe Reeerpine Saccharin Sefrole Soots, tars, and oils Streptozotocin 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCCD) Tlkorium dioxide o-Toluidine hydrochloride Toxaphene Tris(axiridinyl)-phosphine sulfide Tris(2,3-dibromopropyl)phospbate Vinyl chloride * TmmOng PHINYLKNEDfAMINE COMMENT PCIttOO BXTVNOCD; SPECIAL INDUSTRY PANEL FORMED Industry groups seeking extra time to comment on an Environmental Protection Agency advance notice of pro posed rulemaking on phenylenediatnine testing were grant ed partial relief as the agency extended the timetable an additional 30 days to April 8 <47 FH 10597).

Leave existing lead compliance signs in place. b.

Exposure to asbestos can cause fibrosis in the lungs leading to more serious illness like lung cancer.

The Guidelines were developed and published with the understanding that risk assessment is an evolving scientific undertaking and that continued study would lead to change.

The asbestos experience and the introduction of controls would lead to the control of more and more toxic substances with the objective of allowing no more human experiments on a grand scale.

The next module to be developed will be for occupational aedical surveillance records, e.g. blood lead, audiograms.

The Guidelines were developed and published with the understanding that risk assessment is an evolving scien tific undertaking and that continued study would lead to change.

Lead exposures w ill be reported a t a la te r d a te .

The shortness of breath can eventually become in capacitating and lead to death.

The Guidelines were developed and published with the understanding that risk assessment is an evolving scientific undertaking and that continued study would lead to change.

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