AmericanJournal ofPathology, Vol. 134, No. 2, February 1989 Copyright American Association o fPathologists Enhanced M acrophage-Fibroblast Interactions in the Pulmonary Interstitium Increases Fibrosis After Silica Injection to MonocyteDepleted Mice I.

DEPARTMENT OF h .LTH & HUM AN SERVICES From June 6, 1985 QRAC (Quantitative Risk Assessment Committee) ^ CSr c Public Health Servie Memorandum Subject Asbestos in Talc W.

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January 27, 1983 Food Additives Evaluation Branch (HFF-156) Literature on the Relationship of Asbestos in Talc to Ovarian Cancer Allen Haiper(b) Division of Regulatory Guidance (HFF-314) This is in response to your memo of January 19, 1983 with an attached letter from Joan M.

D EC 1982 Raymond J .

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/ ^j' Philippe Ooulllet 1 Holyoke Lane Stony Brook, NY 11790 i * R 3 0 ' .......

ELSEVIER Epidemiologic Evidence for Uterine Growth Factors in the Pathogenesis of Ovarian Cancer DANIEL W.

ELSEVIER Epidemiologic Evidence for Uterine Growth Factors in the Pathogenesis of Ovarian Cancer DANIEL W.

234 GNTER OBERDRSTER TABLE 1 M easured and Norm alized Lung Talc Burden of Rats at the End o f the 4 -Week Inhalation Study o f Talc Exposure concentrations, mg/m3 0 Control 2 (target) 2.3 (actual) 6 (target) 4.3 (actual) 18 (target) ' 17 (actual) Male n tig talc/lung (from NTP report) fig talc/lung per mg/m3exposure concn (% increase over low concn) Female n tig talc/lung fig talc/lung per mg/m3exposure concn (% increase over low concn) 5 4.3 1.6 -- 5 0.58 0.24 -- 5 81.6 2.1 35.5 4 56.5 1.6 24.6 5 186.0 9.3 43.3 (+22%) 5 127.2 9.3 29.6 (+20%) 5 846.0 + 5.5 49.8 (+40%) 5 546.0 35.2 32.1 (+30%) clearance m echanisms, and evidence has been accum u lating th a t these effects are toxicological im plications of a condition of lung "particle overload" (M orrow, 1988).

1 / * Rtillippe Douillet 0he Holyoke lane Stony Brook, New York 11790 Re : Docket No. 83P-0404 Deer Mr.

FUNDAMENTAL AND APPLIED TOXICOLOGY 10, 369-384 (1988) ISSUES Possible Mechanisms to Explain Dust Overloading of the Lungs P.

mm mm FUNDAMENTAL AND APPLIED TOXICOLOGY 10, 369-384(1988) ISSUES 499 Possible Mechanisms to Explain Dust Overloading of the Lungs 506 P.

JOURNAL OF PATHOLOGY, VOL. 158: 7 3 - 8 0 (1 9 8 9 ) SILICA-INDUCED PULMONARY FIBROSIS INVOLVES THE REACTION OF PARTICLES WITH INTERSTITIAL RATHER THAN ALVEOLAR MACROPHAGES D.

JOURNAL OF AEROSOL MEDICINE Volume 1, Number 4, 1988 Mary Ann Liebert, Inc., Publishers infant, child, and )r.