FDA-ers M > that the pilot test will lead to conclusions ab of plants an ^products, and about the kinds of attention na segments of Si^jistry.

As author of the Senate Resolution which could give the people their right to vote directly for President and Vice President, he is leading the effort to abolish the Electoral Colleqe.

We believe the MCA response is the lead ing candidate to be adopted by the DOT as a basis for a rule making proceed ing.

The Act focuses on the ten leading energy-consuming industries by two-digit SIC codes, officially identified early this year.

* TECHNOLOGY ^V Industry's latest cancer scare The deaths of five workers In ten years seem linked to working on the plastic Federal officials met Inst week with plastic* industry executives in Cleve land and Washington to try in deter mine whether the industry has un knowingly l>ecn exposing some of its 6,500 blue-collar workers to fumes that can lead to a rare form of liver cancer known as angiosarcoma.

TO: *As Lis ted FROM: J.

Q I will represent to you this istaown as the 51- rr BARGE Triparte agreenent which led to the assignment of the patents and trademarks relating to Limpet and the head licensing agreement leading to the distribution of Limpet from Armstrong Contracting and Supply to Atlas, the Atlas Division of Bell.

Asbestos exposure may also lead to lung cancer, which has a latency of 15 to 30 years or more.

ASBESTOS INTERNATIONAL ASSOCIATION GLOUCESTER PLACE, LONDON WiH jHL, ENGLAND Telephone; jjjl/j Telegrams Intag London jzt.e, u E.E.C.

Vol.5d,No.3, 1973 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS CEL ELECTROPHORESIS OK PARTIALLY PURIFIED CYTOCHROMES P^5Q FROM LIVKK MICROSOMES OK VARIOUSLY-TREATED RATS Alvlto P.

In dune of 1972, the American Conference of Governmental Industrial Hygienists (AC6IH) adopted an eight hour time weighted average Lli.1t Value (HV) of 200 ppa (Vbl/vbl) for ri*1&Ior1de; Wiu5iSt1oivf^t covering the considerations leading to the adoption of this value mayf6eViff?'

FILE NAME Talc TALC DATE 1977 June 25 DOC TALC139 DOCUMENT DESCRIPTION Medical Journal Article - Cosmetic Talc Powder 1348 THE LANCET JUNE 25 1977 subjects whether manifest in the fasting or in the stimulated state is independent of coexisting obesity and glu- cose intolerance although both are often contributory factors Which is chicken and which is egg is unresolved but experimental evidence favours a causal role for hyperinsulinemia continued administration of insulin to animals in optimal doses can give rise to histological and biochemical lesions resembling those of human atheroma,,and insulin encourages the synthesis of cholesterol and other lipids by arterial tissue both in vivo and in vitro Of the many factors known to cause exaggerated insulin secretion some such as obesity and high sucrose consumption have been implicated on epidemiological grounds in the pathogenesis of ath- erosclerosis whilst others such as increased consumption of sugary alcoholic drinks have so far not been Con- versely certain types of vegetable fibre the exclusion from the diet of which have been claimed to increase the risk of atheroma reduce the immediate and overall in- sulin secretory response to ingested carbohydrate19 with- out adversely affecting glucose tolerance The role of the insulinotropic gastrointestinal hormones in providing the link between composition of the diet and the hyper- insulin^mia of atherosclerosis is undetermined and awaits investigation by the newer methods of measuring them in blood COSMETIC TALC POWDER FROM time immemorial man like his evolutionary predecessors has been exposed to airborne dusts Such exposure is a corollary of living and survival Not unexpectedly therefore the lungs have efficient means of clearing themselves of inhaled particles and a functional reserve such that the accumulation of uncleared dust may be considerable before there is any obvious loss of capacity However it has long been recognised that heavy exposure to dusts such as quartz and asbestos may lead to loss of function and in the case of asbestos to cancer of the pleura and of the lung itself The observation that even casual exposure to asbestos may be associated with increased risk of mesothelioma now occurring at the rate of nearly 200 new cases a year in the United Kingdom has brought into question the safety of other common dusts such as cosmetic talc There are two main concerns Firstly will inhalation of a dust cause loss of function through fibrosis or emphysema And secondly will it predispose to cancer 10.

PAGE4 OF5 000341 8 Attachments 8.1 AttachmentA Chain-of-Custody 8 2 Attachment B: Results. 8.3 Attachment C: Matrix Spike Recoveries (Field and Laboratory Spikes) 8.4 Attachment D: LC/MS/MS Raw Analytical Data 9 Signatures Kevin J Lloyd, Vice President Other Lab Members Contributing to Data Enaksha Wickremesinhe Karen Smith Date PAGESOFS C4J34Z Report Results to: VOCs Total Number of Containers 3MI Envii .mental Laboratory Forai 38778 - PWO Shipping Address; 3M Bldg. 2-3E-09 935 Bush Avenue S t Paul, MN 55106 Telephone: Sample Receiving: (851) 778-4948 Alternate: (651) 778-8753 FAX: (851) 778-6178 Chain of Custody /Reque. jr Laboratory Analytical 17123 Project ID /P roject N a m e g ^ C e T l m p H T - C H w 'T 3 L O * - 0 y y V i / i a L i m i t s Tem plate # (T Finali R eport D u e S i t e Project Lead iZ ^ T S i W i S / l O Internal Due D ate D e p t # (m ain) c 4 Q i^ \ Class/Job/Project # o O t O ~ 3M Env Project# 1 For Inteit.al Us Only Contact Name s Company Date Available Mailing Address -3 -Q 1 PPfrXi _ ____________ Date Due City, State, Z.p S f r . f t l J f , fty/\ Telephone# ______________________ FAX#. li S ll I l 'jS'bDL_____________________ Contract Lab Special Instructions and/or Specific Regulatory Requirements: (method, limit of detection, reporting units, etc) . * *1 * A J-O ^ P re s e rv a tiv e s : < L <L u T ( L `L Analysis Requested: Compiete below.

All door and windows leading into the lower kettle floor or packout areas of 83 Bldg. 5.

PAGE4 OFS 0003 8 Attachments 8.1 Attachment A: Chain-of-Custody 8.2 Attachment B: Results. 8.3 Attachment C: Matrix Spike Recoveries (Field and Laboratory Spikes) 8.4 Attachment D: LC/MS/MSRaw Analytical Data 9 Signatures Other Lab Members Contributing to Data Enaksha Wickremesinhe Karen Smith PAGES OFS C0035S I I 1 I B B B B B I B B B B B B B B Report Results to: VOCs None Other Total Number of Containers 3IV3 Knvil .mental Laboratory Form 30/7 - PWO Shipping Adilrti: 29SJMii>PBOalduugl$.lM2ANJvEe5n05u19e0 ATSFAaeltmlXeer:ppn(hla6eot5eRn1:ee)(:c76e75i8v1-)i6n71g77:66-(667515)3778-4946 Chain of Custody /Reque. j r Laboratory Analytical 1/121 Project ID/Project N am e ( ^ j - g T I f f u H Y j - k r T a a * / t t / i c l Tem plate # ( ^inai Report Due D a tif bK Project Lead r l s jA /J /o < V n Internal Due Date Dept. # (main) | Ciass/Job/Project # Q ) | y^ d )| 3MFoEr nInvteii.dliUPseroOjenclyt # Contact Name Company Mailing Address - 2 -O i VO6 t V , / Date Available Date Due City, State.