Seriously, I don't propose yen adopt thssa methods in the detail Irve ,,ug-gested but I do suggest that you urge; each CTFA fember to cake sfctps now rl.se will lead to ch^ir ability to mv.kc such analyses.

MANUFACTURING CHEMISTS ASSOCIATION 1825 CONNECTICUT AVENUE, N.W.

\ MANUFACTURING CHEMISTS ASSOCIATION R EC E 1825 CONNECTICUT AVENUE, N.W., WASHINGTON.

In workers exposed to high levels of VC, hepatic fibrosis associated with or leading to portal hypertension and angiosarcoma of the liver has been described.1 Vinyl chloride disease has also been associated with dermal induration, acro-ostcolysis, splenomegaly and thrombocytopenia.TM In animals, VC exposure has been reported to cause several types of tumors.4 In a recent report.

2 /o o O ; as I 0 ---------------- --------- Jar conduction defects other than isolated right bundle branch block, angina pectoris, arrhythmia, coronary artery disease).

For the "specificity" (1 - percent false positives) his numbers lead to 1 - 0/21 = 100%.

<Lead and silica have 'p~ob1e~ ,(,p~rha.ps' on t

Another possible effect of organics release is the chelation of heavy metals, which would lead to higher metal concentra tions in the water than would be expected from -the solubility of the metal.

The company's research activities could lead to further improvements even after the new facility is operating, Nelson added.

Lead compounds, quartz, carbonate minerals, clays, halite (NaCl), graphite, micas and alpha-iron were also identified in vari ous samples.

A Occupational disease disclosures more future shocks?

To From INTEROFFICE MEMORANDUM R.

C Cl ^ pci'' C The panel will be composed of independent experts who will make recommendations to FDA.

MANUFACTURING CHEMISTS ASSOCIATION 182b CONNECTICUT AVENUE, N.W.

T.427 TRANSLATION .