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Gehring* The metabolism of inhaled vinylidene chloride in rats represents a balance of biotransformation path ways leading to the formation of a reactive alkylating species which is normally detoxified by conjugation with glutathione.

This discussion is specifically addressed to the issues of dose response, threshold, and leading scientific principles and opinions, etc., as noted immediately above.

that`lead-and silica have probleas/'perhapsnot on the sane scale_uith*' asbestos,-but they are"of concern'in the"T.orh place.

Swedish zinc-lead miners'*, mustard gas workers10, copper smelters exposed to arsenic1', and chioromethyl methyl ether workers11, ` is about as high' among nonsmokers as smokers, although the latency period is reduced in smokers, suggesting a possibl

This will lead to an increase in the level of reactive metabolites and result in an increased reaction of these metabolites with intra cellular macromolecules.

Chem.

I----------------------------------- \ Monsanto fROM (NAME * LOCATION!

The principle ef fect. however, is on the liver--possibiy leading to atrophy, followed by death.

A timetable was established to ensure adequate lead time for finalizing the MCA views and presenting them to the EPA before February 26, 1976.

Ultratbin sections were cut on a Porter-Bium MT2B ultramici otome stained with uranyl acetate and lead citrate and examined with a Philips 200 electron microscope.

MINUTES VINYL CHLORIDE SAFETY ASSOCIATION MEETING Boston, Massachusetts May 15-16- 1975 COMPANY CONFIDENTIAL DISTRIBUTION LIST E.

The company's research activities could lead to further improvements even after the new facility is operating.

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% 46 for io of jrred i the ratic atio with t the conI exi the Jatic m ition ition ified a is :cur,,*ntly v of that Jiag- tcate fort, gists, erra) ition osed .sent fted. hese incer e of f all ding 47 Sci non of Occupational Medicine 305 past occupations, toxic exposures, and places of residence is underway.