VINYL CHLORIDE--RISK ASSESSMENT 17 TABLE 1 Predicted Incidence of Angiosarcoma in Rats Exposed to Vinyl Chloride Using Various Models Versus Dose (u, pg VC Metabolized per day) Compared to Experimental Results Exposure* (ppm) 10,000 6,000 2,300 300 230 30 Dose* (r, /jg/day) 5521 5403 5030 3413 2435 739 Experimental' ("/.) 14.8 (9/61) 21.7(13/60) 22.0(13/59) 11.9(7/59) 6.8 (4/59) 1.7 (1/59) Predicted percentage (Models)* ABCD 19.8 20.0 19,7 18.9 19.3 20.3 19.3 18.6 17.9 18.1 17.9 17.4 12.1 11.8 12J 12.2 8.1 8.0 8.7 8.8 1.4 1.4 2.6 2.8 * From Maltoni and Lefemine (1973). * Calculated from v - [3706(^g VC/4hr)-50<g/liter)]/[8600<s/liter)+S0<g/Uter)], where S -- 2.36 (Af/PPm/litcr)x exposure (ppm) (Gehriog *i at., 1978). * Model A, Probit % - -1.623+1.343 Log (dose); Model B, V, - --1.48 + 0.389 x 10** (dose); Model C, % - 0.3365 x 10-1 (dose); Model D. % - [1-<-*'"*] 100, where ff - 0.38 x 10~*.

Se~` <*Gk.

uf a> Dfri PAMESVIIiE AUl SJUIPUNG PROGRAM Sumary of Results to Date "ny 15* 1973 R b C EIV " D 13/j<.j \ MEDICAL DEPARTMENT A program to sample and an&Jyze the atmosphere in the work ing areas of the plant where employees night be exposed to monomer Vapors was begun in Deoaaber* 1972# using sampling equipment brought to Paines* ville by Dr0 t/ D.

Environmental Defense Fund ' 1525 18th Street, NW, Washington, D.C. 20036 * 202/833-1484 October 4/ 1977 Mr.

DOW CHEMICAL U.S.A June 14, 1977 BENNETT BUILDING 2030 DOW CENTER MIDLAND.

(( Pittsburgh Corning Corporation One Gateway Center Pittsburgh, Pennsylvania 15222 November 5, 1970 o * s-f

IMP33IAL CHTIICAI I.VDuSTSIIS LIMI7TD PLASTICS DIVISION 33333*33 SCAD '.vIL'.

ucc 006292 riMLr ..LAiLUMN ANALYSIS NUMBER umim ,, ^ ^ I-------- " "/- ANALYSIS l|.

nter.office memo TENNEGO CHEMICALS, INC TO J.

i/C- rfL* -'C- NOTICE: This material may be protected by copyright law (Title 17 U.

JOSEPH E, KELLEB JZBOME H.

00-tl4 !

EPA-450/2-75-009 STANDARD SUPPORT AND JKKNTAL IMPACT STATEMENT: EMISSION STANDARD VINYL CHLORIDE Emission Standards and Engineering Division U. s.

Tenneco Chemicals A Tenneco Company P O Box 116 Burlington.

MM INTER-OFFICE MEMO TENNECO CHEMICALS, INC.