This period began when Meriwether the Chief Inspector of Factories in the K. published his annual report with the finding that cancer of the lung or pleura occurred in 13 of individuals found to have asbestosis at autopsy This compared with a risk of 1.3 % in individuals with silicosis Also in 1949 an editorial in the Journal of the American Medical Association accepted the association between asbestosis and lung cancer As you undoubtedly know the JAMA is the most widely read journal among medical practitioners in this country In 1951 Gloyne found 14 of individuals with asbestosis had pulmonary cancer in an autopsy series confirming the findings of Meriwether Also around this time attention was directed to an increase in the female to male ratio for lung cancer in individuals with asbestosis as compared to the general population again supporting an occupational association In 1953 Harriet Hardy and colleagues published two case reports in the American Journal of Medicine with the conclusion that the causal association is highly likely mention this because the American Journal of Medicine has been widely read by physicians specializing in intern- al medicine It is also of some interest but perhaps not entirely relevant to the present discussion that in 1953 and 1954 the suggestion was made that pleural and peritoneal mesotheliomas respectively were associated with asbestos exposure these reports appearing in the German literature During this time period I would conclude that the medical literature might lead the PRIVILEGED PRIVILEPGREIDV LEG D reader to the opinion that the association PRIVILEGED was now " " probable PRIVILEGED PRIVILEGED ung cancer Finally the last time period is 1955 until the present This phase of course began with the publication by Richard Doll using the must valid epidemiologic techniques up to that time to investigate a causal association i.e. a specific mortality study of workers with defined employment in a specific plant He found that employees of this asbestos textile factory had approximately ten times the risk of developing lung cancer than members of the general population He suggested that this risk was confined to those individuals who also had asbestosis Also in 1955 editorials in the British Medical Journal Lancet and American Journal of Clinical Pathology accepted this association as did the author of the most prestigious book on occupational medicine Donald Hunter It would be my judgment that since 1955 the causal association can be considered proven or definite Up to the present time there continues to be some difference of opinion concerning the question of whether the lung cancer risk is limited to individuals with asbestosis or is present in those only with asbestos ex- posure The primary reason for this uncertainty is because the definition of asbestosis is highly variable and on one extreme might be based on thor ough histologic examination with the whole lung available and on the other might depend on several clinical radiographic and physiologic criteria My judgment at present is that it is probable that the level of asbestos exposure necessary to result in detectable excess risk for developing lung cancer is also a dose which is likely to produce diffuse changes of pulmonary fibrosis asbestosis However the evidence of asbestosis may not be clinically or radiographically apparent I hope this discussion is useful You will of course appreciate that the time periods indicated above are arbitrary I would be most pleased to discuss any of these opinions with you or to provide clarification where required With kindest regards Sincerely yours HW cc Mr.

The analysis which follows leads to the conclusion that a new vinyl chloride source which begins construction after June 2, 1977, must be given approval to construct if it meets the presently promulgated standards.

MONTAC 1040 would be an alternate to the use of lead solder. *5) Sorbic Acid.

INORGANIC RESEARCH 1-1 1-2 1-3 1-4 1-3 1-6 1-7 1-8 1-9 1-10 1-11 AUTO EMISSIONS CATALYST SEA WATER SCALE INHIBITOR FUSION BONDED VERMICULITE BOARD APPLICATIONS OF VERMICULITE BOARDS GASOLINE LEAD ADSORBENT ESTER GUM REPLACEMENTS LEAF AUTOMATION NPD 71-6674-B, SPECIAL NUCLEAR MATERIAL RECYCLE FUELS SPECIALTY METAL PARTS ' METAL SUPPORT FOR CATALYST ORGANIC RESEARCH 0-1 0-2 0-3 0-4 0-5 0-6 0-7 0-8 0-9 0-10 0-11 0-12 0-13 0-14 0-15 0-16 WET STRENGTH AGENTS FOR PAPER PAPER COATINGS - DEVELOPMENT OF AQUEOUS DIELECTRIC COATINGS GLYCINE/LACTAMIDE PROCESSES TEXTILE ADDITIVES HAMPSHIRE/REXOLIN PROJECTS DARAMIC EXTRACTION RESEARCH LOW COST CATIONIC POLYELECTROLYTES ENDURA PROJECTS SEA WATER SCALE INHIBITORS CAN END FASTENING SYSTEM OVERSTRIP RESIN FOR CONOWELD SIDE SEAM BLOCKED AMINE CHEMISTRY PACKAGING MATERIALS - NON HALOGENATED BARRIER MATERIALS FKOIODEGRADABLE POLYSTYRENE POLYSTYRENE FOAM STRIPPABLE COATINGS 15208313 Cabl e Grace rad Tel. (301) 531 5711 T1X - 710 862 1886 CONSOLIDATED EDITION 2 October 12, 1971 CLP TASK FORCE RESEARCH C-l C-2 C-3 C-4 C-5 C-6 CLP LITHOGRAPHIC PRINTING PLATE LETTERFLEX - IMPROVED PRINTING QUALITY CLP INKS SOLID LETTERFLEX PLATE Q-43 CROSSLINKING AGENT AND B MERCAPTOPROPIONIC ACID DRY FILM PHOTORESIST AGRICULTURAL & CONSTRUCTION MATERIALS RESEARCH A-1 A-2 A-3 A-4 A-5 WELLMAN-POWER GAS S02 RECOVERY FORMULATION AND EVALUATION OF MONO-KOTE SILICATE CONSTRUCTION MATERIALS FLORIDA EXPERIMENTAL STATION, FT.

For the production of this much desired material, wiich can be combined in so many different ways with plasticisers, fillers and pigments that it has become one of the leading products of the plastics age within the last twenty years, is apparently very much more dangerous than had been previously been assumed

The designation of any solvent as a "safety solvent" was deplored, as leading to excessive carelessness in use. 9.

In vinyl chloride and two sister compounds, dustry officials had warned that the, rulf ethylene dichloride and polyvinyl chloride, was so harsh it could lead to a total closi install "best available" technology to limit down of plants making PVC plastic vinyl emissions from their plants.

. - Usually because he likes the comfort of the particular respirator or 'is following the lead of someone else.

Questions regarding use of colorants which are not listed in the new Order may well lead to the filing of Petitions for their clearances, although it is understood that some of them do not migrate into food.

Bill did a good job of organizing and leading.

D February 3, 1971 Pag Thrt As to whether or not such uses could lead to the PCB's getting Into the environment, I wonder If In late 1969 when we supplied the statement to "Envir onment" you would have predicted the current situation as regards mercury. 4. we have not had any oases of occupational illness in our workers manufacturing PCB's, with the one exception mentioned (page 307* J.

We ultimately made the point that if they want to lead in the U.K., they should be the first to move to a linear phthalate since the users can readily pick up (or Armoride can demonstrate) by fogging, low temperature, volatility, cellulose nitrate migration resistance, etc, the performance of their product which could not be met by DAP.

s leading geologists, Lenin Prize Winner, F.

If the same criteria were to be applied to indirect additives as the SOM document will propose for drug resi dues, and we are told this is a likely eventuality, a finding of "non-detected" with a validated analytical procedure capable of detecting approximately 6.5 ppb in food simu lating solvents would lead to the regulatory conclusion that there is no reasonable expectation of vinyl chloride extraction into food.

MATERIAL Ammonia Arsenic Asbestos Benzene Calcium Oxide Carbon Monoxide i Chromium Chromic Acid Coal Dust Coal Tar Pitch Volatiles Copper Fluorides Graphite Hydrogen Chloride Hydrogen Cyanide Hydrogen Sulphide Iron Oxide Fume Lead Manganese Mercury .Methyl Ethyl Ketone AREA OF POSSIBLE EXPOSURE - galvanizing lines 7 raw material impurity - bag houses, insulation, welding rod - coke by-products - refractories, sinter oxide, flux - blast furnaces, coke plant - ladle furnace additions - tinning, galvanizing - coal handling - coking, by-products, blast'furnace, BOF relining, roofing, paving, foundry - scrap melting, welding - teeming, HF pickling, mold washes - blast furnaces, BOF, foundries - pickle lines - coke by-products, foundry, blast furnaces, plating lines - blast furnaces, coke plant - furnaces, burning strap Durmng, zinc pigs, patenting, wire drawings, additions furnace additions instrument shop paint shop, cleaning generally ' Methylene Chloride Molybdenum Naptha (coal tar) Naptha!