Thi*s was followed by a roundtable discussion in closed session lead by Chairman,, David R.

They feel strongly that "incompetent or biased studies which lead ultimately to confusion, controversy and erosion of credibility within the scientific community, do irreparable harm" . . . and they quote Senator Kennedy in the Congressional hearing on FDA preclinical testing: NOTED: J.V.

in addition: --1 am doubling the reward offered for information leading to the arrest and conviction of those responsible for the spills, to $S,OQQ.

irrjnTrT>.Ttr-t--^ j; &Ycnvf rrTluartion in the form of chloracne, systematic intoxication leads to nausea, vomiting;, loss of weight, edema and abdominal paii Remo*vneu tiru lib from wer>xCp(OoUsUuS re.

Ashton If I apply the same standards that would be used in reviewing a paper for publication in a professional journal I believe that the language needs refinement and tightening The organization could be improved and referencing should be more detailed For example I see no reference to the Gandolfi method for XRD But the sciencies good The authors correctly identify speci- men flatness and placement tangent to the focussing circle as critical factors in accurate measurements of d Many accomplished diffractionists are unaware of the need for this care A displacement of 0.1 mm of the sample surface can lead to errors of 0.1 with modern diffractometers The authors correctly stress that it is fruitless to attempt amphibole species identification on the basis of the reflection at 8.4^ The amphibole group is very complicated chemically and hence in terms of nomenclature yet the structure is sufficiently similar throughout the group so that identifications based on a few lines are meaningless The authors point out the danger of identification based on a single peak Again this technique is risky Silicate minerals all have lattice planeisn great abundance whose spacings are of the order of 1.5 to 4^ However considerably more meaning can be attached to very large d single reflections such as the chlorite at 14.2^ A reflection thered can only be among the common silicate minerals vermiculite or chlorite The authors correctly stress the need to look for this reflection in separating the effects of chlorite from serpentinoer kaolinite Un- fortunately though some minerals provide only one peak of detectable in mixtures intensity These are the rhombohedral carbonates but they _ are not discussed in the paper I cannot speasko authoratatively on the morphological of talc and amphibole but their observations are in good accord own experience varieties with my JNJ 000252253 Miller Reynolds Page 2 29 April 1977 I must agree with their conclusions that diffraction patterns of mixtures of 14A chlorite and vermiculite and 7A kaolinite ser- pentine minerals are almost impossible to interpret unless the minerals happen to be well crystallized and of high abundance so that many re- flections are present Even then some varieties will give anomalous results For example rich chlorite has a very weak 001 and can be easily confused with serpentine or Kaolinite In addition theand ranges of unit cell parameters for these minerals overlap so that only some species can be confidently identified either separately or in mix- tures in talc The authors criticize using the quartz 211 samples This approach is so poor that I am to determine quartz surprised that any- one has used it In summary I find that the paper gives good evidence that the of authors know their business Each pitfall is a valid criticism ray methods I strongly agree with their conclusions that standard powder ray diffractometry cannot always provide accurate information on the kinds and amounts of minerals that are found in talc ores and talc products Sincerely RC Raynald Raynald ( Bob ) R.C.

I realize that these requirements are being set forth in the interest of maintaining the highest personal safety and protecting product quality and these certainly have to be our main considerations; but for those who have the responsibility of accepting EDO shipments, these increased re quirements will require longer lead times in order for us to find suitable vessels capable of meeting these requirements.

Paragraph 6 was completely removed and the two lead paragraphs on -page--11-of the booklet were inserted in its place.

j New group--To answer critics ` and to present the positive side of the issue, eight leading as bestos product companies have organized the Asbestos Informa tion Assn.

Manufacturing indicates they can make bulk shipments if sufficient lead time is given.

Finally, consideration of the functional symptoms and the smoll perturbations in lung function tests leads one to think that the amount of fibrosis is very limited and difficult to dissociate from the use of tobacco.

Ill i raead rmpliliil, Un MaN aN ths firm was violating atotoandtadamlragabthanby' dbddfBagaseadlvnaiiNanta af Kl Into Un DM from ' mm Mit FMail Edwards and MmI FFatlla. i II i____ "Am "trim Un llrir dwh| Un pad N NtlHilUBttfhrtwhf lad MO, Environmental Cmervattan Commtodnner Ogden Raid warnrd Naw Yaafean agabd aallau oaitaln rartottaa of dak takan from the HadMn, which ha aald had bm fowad la bm PCB larala . above tha flaa parts par milUan Ibnlt sd by tho Faad and Drag Tha oaanpialnt aNo propoaaa , that Un company ba foroad to poN mtolmam aanpUanct bond of at lead tl raUttoii and la daaiMip Hi PCB paUaUoai la Un river.

I should be grateful for any lead you can give me towards a solution.

May Also Lead Agency to ,,, A Total Ban in Any Food OS\N 323568 !

Incidentally, this was the only female who had been included in the study, and she was added in order to determine for the record, whether or not the response of the female of the human species differed in any significant manner from the male in response to the absorption of lead.

";fr'ALV"OLO I'Uil wAtul SECTION V HEALTH HAZARD DATA |IMIfe'l<fn0"irr^lla^lon In the form of chloracne, systematic Intoxication leads to nausea, vomiting, loss of weight, edema and abdominal pair' iiMiv,r.c> >o imsi aid bbocioubis Heemmeove from exposure.