PIGMENT: 77.80* Titanium Dioxide 125 Carbonate White Lead 60 35# Leaded Zinc 150 15# Leaded zinc 115 Magnesium Silicate 250 Sulphate White Lead 126 Silica 100 VEHICLE: 22.20# Refined Linseed Oil Heat Bodied Linseed Drier Mineral Solrlts Raw Linseed Oil 85 22 30 49 78 CALCULATED YEIIL 1190 MANUFACTURING LOSS 3# ACTUAL YIELD YIELD IN GALLONS 4.00 1.06 3.00 2.41 10.62 2.27 4.53 11.00 Gal. 2.75 4.25 7.50 10.00 63.39 Gal. 1.89 61.50 Gal.

White Lead per D.C,h.W, Hr.

White Lead per D.C.K.W.

White Lead per D.C.H.W.

White Lead per D.C.K.W.

PIGMENT: 77.80* Titanium Dioxide 125 Carbonate White Lead 60 35# Leaded Zinc 150 15# Leaded zinc 115 Magnesium Silicate 250 Sulphate White Lead 126 Silica 100 VEHICLE: 22.20# Refined Linseed Oil Heat Bodied Linseed Drier Mineral Solrlts Raw Linseed Oil 85 22 30 49 78 CALCULATED YEIIL 1190 MANUFACTURING LOSS 3# ACTUAL YIELD YIELD IN GALLONS 4.00 1.06 3.00 2.41 10.62 2.27 4.53 11.00 Gal. 2.75 4.25 7.50 10.00 63.39 Gal. 1.89 61.50 Gal.

White Lead per D.C.K.W. 2,616 ' 103.61 47.44 4.7371 DEPARTMENTAL OPERATIONS: Days Operated per Week Cell Room: 7 Filter; 7 ' Dryer: 7 Barrelling: 6 Average Production Tons Per Day 15.41 15.11 15.11 17.47 Base white lead, tales prio* per pound, carload lets in barrels 8-1/4^ Yours very truly, MBS:epv S.

Joseph Lead Company, Nev; York, N.Y.

White Lead par D.C.K.W.

White Lead per D.C.S.W.

Cleanlnr, and Repairing of Tanker Compartments which have contained leaded gasoline.

;-:im Ihy *e XMT 1 The value of our lead otetlstics should not Vo underestimated.

by studying p o to n tio m s tric a lly c e r ta in s o lu tio n s o f sodium c i t r a t e and lo a d n i t r a t e I -was a b le t o a r r i v e a t a fo rm u la and a d is s o c ia tio n c o n s ta n t ( a t th e io n ic s tr e n g th end pH o f p l a s m ) f o r a le a d c i t r a t e complex w hich I " had p re v io u s ly shown to e x is t* From th e v a lu e f o r t h i s c o n s ta n t and th e norm al c i t r a t e c o n c e n tra tio n in human b lo o d i t was p o s s ib le to a r r iv e a t a v alu e o f about 20 fo r th e r a tio s (lo a d c i t r a t e complex)/ ( lead io n )* To s t a t e i t sim ply th o se d a ta in d ic a te t h a t 20 tim es as much load e x is te d as a so lu b le lead c i t r a t e io n th a n as sim ple lead ion* Mince w ith o u t knowledge o f th e presence o f so lu b le complexes o f lead in th e blood a l l th e so lu b le le a d m ust be in th e f o r a o f th e sim p le le a d *on, I Tree a b le t o s t a t e t h a t 11t h e norm al b lo o d c i t r a t e i s c a p a b le o f k eep in g i n so lu tio n . sn amount o f load 20 tim es as g reat as th a t which tho s o lu b ility o f the in so lu b le lead compounds o f th o body would o th e rw is e p e rm it* I do n o t ace how your fin d in g s o f lo s s th a n 10.5 o f th o blood le a d in th o sensei ( a f a c t w hich I had alw ays assumed as so on p u re ly th e o r e tic a l groundc) in any way c a s ts doubt on o r i s even p e r t i n e n t to my co n clu sio n * b o te t h a t I d id n o t say t h a t c i t r a t e o f norm al blood keeps 20 tim e s a s much le a d i n s o lu tio n ns i n in s o lu b le form* i-ote a ls o th a t you have no reason fo r assuming th a t blood in plasma is in ' s o lu tio n ,a s a m a tte r o f f a c t th e re is good re a so n t o f e e l th a t m ost o f th e plasm a lo a d i s n o n - d if f u s ib le * bven w ith 1,5 o f th o le a d o f th e b lo o d p r e s e n t in th e p la s m th e re could s t i l l be 20 tim es a s much le a d w e s e n t as th e c i t r a t e complex than as sim ple load ion* In o n ly one o &bq do y o u r r e s u l t s ap p ro ach p e rtin e n c e t o my c o n clu sio n s* N13982 This i s your experim ent w ith c i t r a t e a s an a n t i~o ongule n t * From p u re ly th e o re tic a l co n sid eratio n s I should expect c itr a te to cause mi in crease in plasma lead a t th e expense o f e ry th ro c y te lead* b u t oven here a f a ilu r e to observe such a r e d is tr ib u tio n would n o t r e f l e c t upon th e v a lid ity of njr co n clu sio n s sin c e c i t r a t e co u ld cau se an in c re a s e in d if f u s ib le over n o n -aiffu sib le lead e n tire ly w ithin th e p lasm lead frac tio n w ithout causing a change in t o t a l lead in th e p lasm * In your experim ent , however th e o i t r a t o wae in c o n ta c t w ith th e whole blood o n ly m om entarily b efo re c e n trifu g a tio n - ijardly a f a i r lortfith of tim e in which to d e te c t changes in so complex a system o f e q u ilib ria N e v e rth e le ss, th o you fin d no s ig n if i c a n t change in plasm a lead a f t e r th e a d d itio n of c i t r a t e , 1 f in d on exam ining your own f ig u r e s a s i g n i f i c a n t in c r e a s e i n p la s m le a d where c i t r a t e was used over t h a t w ith no a n tic o a g u la n t* t T i* o'-io ig n o re s th o ''le s s th a n " s ig n i n th o e x p erim en t on an im a l 7 on f in d s a mean in c r e a s e in plasm a le a d w ith o i t r a t o o f 45/ w ith a s ta n d a rd e r r o r o f 15*4, a t v a lu e o f 2*S2 and a p v a lu e o f 0*05 o r le s s -which i s c e r t a i n l y s ig n if ic a n t* I f on le a n s ov er backwards and c a l l s th e in c re a s e in anim al V n i l , one fin d s a mean in c re a s e o f 40$ w ith a sta n d a rd e r r o r o f 1 7 ,1 , a t o f 2*54 and a p value s lig h tly g re a te r than 0 ,0 5 , which c e rta in ly approaches s t a t i s t i c a l s i g n i f i c a n c e ) Ih u s we f in d t h a t f a r from c a s tin g do u b t on my c o n c lu s io n s , th o one p e r t i n e n t sxperitror v i.n y o u r p ap er a c t u a l l y eon* firm s my t h e o r e t i c a l p re d ic tio n s * \ i As a m a tte r o f f a c t f o r th o p a s t s i x months 1 have boon w orking in a s s o c ia ti o n w ith Nr* Aubifea an e f f o r t , among o th e r t h i n g s , to t o s t my th e o re tic a l conclusions as th ey apply to tho lead p a r titio n in blood in v itro and in vivo, i t req u ires ra re than an understanding of the p a rtitio n o f lead between plasma and c o lls to oonfirm o r r e je c t th e sig n ific a n c e of th e lead c i t r a t e complex in th e s ta te o f lead in th e blood* A d ir e c t approach would be by a study o f lead ion c o n ce n tra tio n in blood, b u t cinoe th a t is m a n ife stly im possible w ith p re se n t te c h n iq u e s, an approach can be made by stu d y in g th e d i f f u s i b l e f r a c tio n o f p la s m load and th o e f f e c t o f o itr a to thereon* Perhaps 1 , i n t u r n hove m isu n d ersto o d your c r i t i c i s m o f my c o n c lu s io n s * I f so above explanation m y have boon unnecessary* Aside from tlia t one reg etao $ l k fco o n etru ctio n I f e e l th a t your paper was most in te r o p tin g and has answered a problem o f fundam ental im portance in th e physiology of lead eoinoning* "legp o e t f u l l y , X E 0012267 Coymour f* f e t y

Tooelt illami Barltao Befinery Lead - Us.

Tooelt illami Barltao Befinery Lead - Us.