Comment on Proposed Restriction of PFAS Aug 25, 2023 Japan Valve Manufactures' Association (JVMA) Japan Valve Manufacturers Association (JVMA) appreciates the opportunity to provide comments to the PFAS restriction proposal. 1.

Apr 25, 2023 Comment on Proposed Restriction of PFAS Conference of Fluoro-Chemical Product Japan (FCJ) On behalf of chemical manufacturers, we, Conference of Fluoro-Chemical Product Japan (FCJ), have been working tirelessly to comply with national chemical regulations.

Position of Hamilton Bonaduz AG, Business Unit Process Analytics on the draft for a restriction of PFASs Content 1 Summary ......................................................................................................................................... 2 2 Background...................................................................................................................................... 3 3 Chronology of the restricon .......................................................................................................... 5 3.1 PFOS......................................................................................................................................... 5 3.2 PFOA ........................................................................................................................................ 5 3.3 PFHxS ....................................................................................................................................... 5 3.4 PFAS ......................................................................................................................................... 5 4 PFAS in PharmaTech and Equipment of Sophiscated Chemical Analycs ..................................... 7 5 Content of the dra Restricon..................................................................................................... 11 6 Full ban .......................................................................................................................................... 12 7 Posions of Hamilton Bonaduz AG, Business Unit Process Analycs ........................................... 13 7.1 Role of PharmaTech and Sophiscated Laboratory Analycs in the Restricon Dra .......... 13 7.2 Abandonment of ,,essenal use" and specific risk assessment ............................................ 13 7.3 Fluoropolymere ,,of low concern" ......................................................................................... 14 7.4 Missing alternaves............................................................................................................... 16 7.5 Impact on PharmaTech and Equipment for Sophiscated Chemical Analycs ..................... 17 7.6 Emissions and emission prevenon ...................................................................................... 18 7.7 Assessments from outside the EU......................................................................................... 19 8 Literature reference....................................................................................................................... 21 12.

Environ.

MEMOS NON-CONFIDENTIAL REPORT TO THE PUBLIC CONSULTATION ON THE REACH RESTRICTION PROPOSAL ON PER- AND POLYFLUOROALKYL SUBSTANCES (PFAS) Contents 1 MEMOS Company Profile ................................................................................................................ 1 2 MEMOS membranes ....................................................................................................................... 1 2.1 Process Description for PVDF (Polyvinylidene fluoride) membranes ..................................... 2 2.2 Emissions in the Manufacture phase ...................................................................................... 2 2.2.1 PFAS Emissions in the Wastewater ................................................................................. 2 2.2.2 PFAS Emissions in the Air ................................................................................................ 2 2.2.3 PFAS in Disposal............................................................................................................... 2 2.3 Emissions in the Use Phase: .................................................................................................... 2 3 Missing uses for PVDF membranes ................................................................................................. 3 3.1 PVDF Membranes in Water Treatment/Wastewater Filtration.............................................. 3 3.2 Fruit Juice Filtration................................................................................................................. 3 4 Socio-Economic Analysis ................................................................................................................. 4 5 Literature ......................................................................................................................................... 4 6 Annex............................................................................................................................................... 5 1 MEMOS Company Proile MEMOS Membranes Modules Systems GmbH is a small to medium-sized enterprise (KMU).

European Chemicals Agency PFAS consultation Rodicio, Jose L Consultant of General Surgery.

Assogomma comments on the Annex XV Dossier of the universal PFAS restriction proposal September, 6th 2023 1 1.

Lenzing Innovative by nature www.lenzing.com Ergeht per online Formular an: Europische Chemikalienagentur Lenzing Aktiengesellschaft Werkstrae 2 4860 Lenzing, Austria www.lenzing.com Telefon +43 (0) 7672 701-3609 Mobile E-Mail M@Ienzing.com Datum 22.09.2023 Beschrnkung der Stoffgruppe PFAS Sehr geehrte Damen und Herren!

Estimation of the nb of sequences in PcPc using TFA for synthesis PcPc Data on May-23 nb* % using TFA nb using TFA Dipeptides 82 0% 0 mostly made by liquid phase not using TFA Tripeptides 116 50% 58 Tetrapeptides 113 90% 101 Pentapeptides 120 95% 114 Hexapeptides Heptapeptides 119 95% 79 95% 113 mostly made by SPPS (using TFA) 75 Octapeptides 64 95% 60 Nonapeptides 63 95% 59 Decapeptides 85 95% 80 Oligopeptides (>10AA) 303 10% 30 lower sequences made by SPPS, larger made by biotechno Polypeptides (>100AA) - 0% - mostly made by biotechnology total 1144 total using TFA 690 60% estimated values * these numbers are based on the peptidic "core name" (without prefix and suffix) and may be under evaluated (ex: tripeptide-1; acetyl-tripeptide-1; palmitoyl-tripeptide-1; copper tripeptide-1 are only one sequence in this count!)

Apr 25, 2023 Comment on Proposed Restriction of PFAS Conference of Fluoro-Chemical Product Japan (FCJ) On behalf of chemical manufacturers, we, Conference of Fluoro-Chemical Product Japan (FCJ), have been working tirelessly to comply with national chemical regulations.

September 22, 2023 Non-confidential comments for Annex XV restriction report: Alternatives to fluorinated gases Dear Madame or Sir, We welcome the opportunity to provide input on the restriction proposal regarding per- and polyfluoroalkyl substances (PFAS).

PFAS restriction ACEA/CLEPA COMMENTS ON THE ANNEX XV DOSSIER OF THE UNIVERSAL PFAS RESTRICTION PROPOSAL September 2023 Second submission ACEA - European Automobile Manufacturers' Association CLEPA - European Association of Automotive Suppliers 1 WHO WE REPRESENT ABOUT ACEA The European Automobile Manufacturers' Association is a professional association uniting 14 major mobility actors on the European market. 13.0 million Europeans work in the auto industry (directly and indirectly), accounting for 7% of all EU jobs. 11.5% of EU manufacturing jobs - some 3.4 million - are in the automotive sector.

EDRA Comments for Annex XV restriction report Our sector views the possible wide impact of the restriction as leading to a situation where there are no alternatives available in many product areas, with consequent difficulties to purchase and sell some of the product groups.

CD CARRAR 24/09/2023 Carrar's position paper of PFAS ban The Importance of Hydrofluoroolefins in the EV Sector and the Impact of the Proposed Pfas Restrictions on the Sector Edited by Date Change description Rev No Document name Relation Fax: 972-8-9338820 / Email: M_Pcarrar.net / www.carrar.net Sapirim Industial Park, Shaar Hanegev, Israel Q CARRAR 24/09/2023 Table of Contents 1.

SUMMARY OF GLOBAL PEPTIDES MARKET Peptides therapeutics drugs is a global growing market that in 2022 represented a market size of 43.11 USD billions and projections performed by different agencies (included Bloomberg) are that the business will increase by 78% in ten years, reaching 76.83 USD billions.