5 September 2023 ToxProfiler Report Final version Toxys project code: Sponsor reference: Date: 23063 MA-RR-23-5046 2023 09 08 Toxys B.V.

2023 Emerson's Request for the Creation of a New Industrial Automation Monitoring and Control Use Sector and a 12-Year Derogation for Fluoropolymers in that Sector Section IV, Non-Confidential Attachment May 9, 2023 Contents 1.0 Introduction ...................................................................................................................................... 4 2.0 Purpose ............................................................................................................................................. 4 3.0 Industry Description.......................................................................................................................... 5 4.0 Implications....................................................................................................................................... 7 5.0 PFAS Functionality............................................................................................................................. 8 6.0 Alternatives ..................................................................................................................................... 14 7.0 Annual Tonnage and Emissions ...................................................................................................... 17 8.0 Socioeconomic Implications ........................................................................................................... 18 9.0 End-Of-Life ...................................................................................................................................... 19 10.0 Ending Statement............................................................................................................................ 19 1 Cross Reference Matrix As per the REACH Annex XV PFAS Restriction proposal, a cross-reference matrix is provided as a tool to assist in the evaluation.

September 25th, 2023 ECHA Committee do European Chemicals Agency P.O.

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Acronym 4:2 FTSA 8:2 FTSA C6/C10 PFPiA C6/C8 PFPiA g 4:2 Cl-PFESA 6:2 Cl-PFESA 6:2 diPAP 6:2 FTOH 6:2 FTSA 8:2 Cl-PFESA 8:2 diPAP 8:2 FTOH 8:2 FTSA ADME ADONA AEC AFFF AIX ALT AR ASBT BAC BAF BCF BIONIC BMF BMI br-PFOS BSA BUN BW C6/C12 PFPiA C6/C6 PFPiA C6/C8 PFPiA C8/C10 PFPiA C8/C8 PFPiA CAR CASRN CEN CFCs ChG CHO CI CLP Cl-PFAES CMR COD CSS CTD CYP19 d DHT DMEL DMSO DMW DNEL DOC dpf DPW dw E2 EA EbC50 EC50 ECF ECOS ED ED-RIA EEA-NH4 EFSA EFSA CONTAM ELISA ER ErC50 EtFASAs EtFOSA EtFOSAA EU F- gases F0 F-53B FASAs FC-807 F-DIOX FEP fEPSP FOB FOSA FSH GAC GAC filter GenX GHG GLP GSI GWP HCFCs HEK293 HFCs HFEs HFOs HFPO HFPO-DA HFPO-TA HFPO-TeA HI HOTf hpf HPG HPT HSI IARC IC50 IPCC Kd kg KPFBS LBD LC LC50 LDL LH lin-PFOS LOAEL LOD log D BSAw log D mpw log D mw log D ow LOQ LRTP LTP MAC Directive MDL MeFASAs Me-FBSA MeFOSAA MEK mg MoA Move3 mRNA Mv31 mv31 K+ n:2 FTOHs n:2 FTSAs n:2 PAPs ng NILU NOAEL NOEC NTCP OAT OATPs OBS Oct-1 OECD OECD/UNEP Glob PAC filter PACF PAPs PASFs PBSF PBT PBTK PCTFE PEVE PFA PFAIs PFAS PFBA PFBPA PFBS PFCAs PFCs PFDA PFdiCA PFdiSA PFDoDA PFDPA PFDS PFE alkanes PFEAs PFECAs PFECHS PFEE PFEPA PFESA PFESAs PFEtS PFHpA PFHpDA PFHpS PFHxA PFHxDA PFHxPA PFHxS PFME PFMPA PFNA PFO4DA PFO5DoDA PFOA PFOcDA PFODA PFOPA PFOS PFOSA PFOSI PFPAs PFPeA PFPeDA PFPeS PFPiAs PFPPA PFPrA PFPrS PFSAs PFSIA PFSIAs PFTeDA PFTrDA PFUnDA PFAAs PMVE PolyFEAAs PolyFAAs POP POSE Pov PPAR PPVE PTFE PVDF PXR QSAR RAC RCF RMMs SAmPAP SC SEAC SFAs SOD STP SVHC T3 T4 TBG TF TFA TFMS TfOH TFSA TH TMF TNF- TSH TTR TWI US EPA vPvB VTG ww WWTP Explanation 4:2 fluorotelomer sulfonic acid 8:2 fluorotelomer sulfonic acid Perfluorohexylperfluorodecyl phosphinic acid Perfluorohexylperfluorooctyl phosphinate Microgram 4:2 Cl-polyfluorinated ether sulfonate 6:2 chlorinated polyfluorinated ether sulfonate 6:2 fluorotelomer phosphate diester 6:2 fluorotelomer alcohol 6:2 fluorotelomer sulfonic acid 8:2 Cl-polyfluorinated ether sulfonate Bis[2-(perfluorooctyl)ethyl] phosphate 8:2 fluorotelomer alcohol 8:2 fluorotelomer sulfonic acid Absorption, distribution, metabolism, and excretion Ammonium 4,8-dioxa-3H-perfluorononanoate, 3H-perfluoro-3-[(3-methoxy-propoxy)propanoic acid] Anion Exchange Capacity Aqueous Film-Forming Foam Anion Exchange Serum alanine transferase Androgen Receptor Apical Sodium-Dependent Bile Salt Transporter Biological activated carbon Bioaccumulation Factor Bioconcentration Factor Bioconcentration model for Ionogenic Organic Compounds Biomagnification Factor Bodymass Index Branched PFOS Bovine Serum Albumine Blood Urea Nitrogen Body Weight C6/C12 Perfluorophosphinic acids C6/C6 Perfluorophosphinic acids C6/C8 Perfluorophosphinic acids C8/C10 Perfluorophosphinic acids C8/C8 Perfluorophosphinic acids Constitutive Androstane Receptor Chemical Abstracts Service Registry Number Chicken Embryonic Neuronal Ozone depleting chlorofluorocarbons Choriogenin Chinese Hamster Ovary Confidence Interval Classification, Labelling and Packaging Chlorinated Polyfluorinated Ether Sulfonate Carcinogenic, mutagenic or toxic for reproduction Chemical Oxygen Demand Chemicals Strategy for Sustainability Characteristic Travel Distance Cytochrome P-19 Days Post Fertilization 5 Alpha-Androstan-17-Beta-Ol-3-One Derived minimal effect level Dimethylsulphoxide Distribution ratios for membrane-water Detected No-Effect Level Dissolved Organic Carbon Days Post Fertilization Distribution ratios for protein-water Dry Weight Estrogen/17-Beta-Estradiol Endocrine Activity Effect Concentration Algal Biomass Effect Concentration Electrochemical fluorination The Environmental Coalition on Standards Endocrine Disruption Direct Equilibrium Dialysis Followed By Radioimmunoassay Ammonium difluoro[1,1,2,2-tetrafluoro-2-(pentafluoroethoxy)ethoxy]acetate European Food Safety Authority European Food Safety Authority- Panel on Contaminants in the Food Chain Enzyme-Linked Immunosorbent Assay Estrogen Receptor Effect Concentration Algal Growth N-ethyl perfluoroalkane sulfonamides N-ethyl perfluorooctane sulfonamide N-ethyl perfluorooctane sulfonamidoacetic acid European Union Fluorinated gases Parental Generation 6:2 Cl-polyfluorinated ether sulfonate (6:2 Cl-PFESA) Perfluoroalkane sulfonamides Ammonium bis[2-[N-ethyl (heptadecafluorooctane) Ammonium difluoro{[2,2,4,5-tetrafluoro-5-(trifluoromethoxy)-1,3-dioxolan-4-yl]oxy}acetate Fluorinated ethylene propylene Field Excitatory Postsynaptic Potential Functional Observational Battery Perfluorooctane sulfonamide Follicle Stimulating Hormone Granular Acticated Carbon Granular activated carbon filter see HFPO-DA, 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid Greenhouse Gas Good Laboratory Practice Gonadosomatic Index Global Warming Potential Hydrochlorofluorocarbons Human Embryonic Kidney 293 Hydrofluorocarbons Hydrofluoroethers Hydrofluoroolefins Trifluoro(trifluoromethyl)oxirane; Hexafluoro-1,2-epoxypropane; 2,2,3-Trifluoro-3-(trifluoromethyl)oxirane Hexafluoropropylene oxide dimer acid, 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid, FRD-903, Ge Hexafluoropropylene oxide trimer acid, 2,3,3,3-tetrafluoro-2-[1,1,2,3,3,3-hexafluoro-2-(heptafluoropropoxy)p Hexafluoropropylene oxide tetramer acid Hazard Index Trifluoromethanesulfonic acid Hours Post Fertilization Hypothalamus-Pituitary-Gonad Hypothalamus-Pituitary-Thyroid Hepatosomatic Index The International Agency for Research on Cancer Inhibitory Concentration Intergovernmental Panel on Climate Change sediment/water distribution coefficients Kilogram Potassium Perfluorobutane Sulfonate Ligand Binding Domain Long-chain Lethal Concentration Low-density-lipoprotein Luteinizing Hormone Linear PFOS Lowest Observed Adverse Effect Level Limit Of Detection Base-10 logarithm of albumin-water distribution coefficients Base-10 logarithm of protein-water distribution coefficients Base-10 logarithm of of membrane-water distribution coefficients Base-10 logarithm of octanol-water distribution coefficients Limit Of Quantification Long-Range Transport Potential Long-Term Potentiation Mobile Air-Conditioning Directive Method Detection Limit N-methyl perfluoroalkane sulfonamides N-metylperfluorobutane Sulfonamide N-methyl perfluorooctane sulfonamidoacetic acid MAPK/ERK Kinase Milligram Mode of Action 1-[difluoro(trifluoromethoxy)methoxy]-1,2,2-trifluoroethylene Messenger-RNA 1,1,2,2,3,3-hexafluoro-1-trifluoromethoxy-3-trifluorovinyloxypropane Potassium 2-(3-trifluoromethoxy-1,1,2,2,3,3-hexafluoropropoxy)-2,3,3,3-tetrafluoropropionate n:2 fluorotelomer alcohols n:2 fluorotelomer sulfonic acids n:2 polyfluoroalkyl phosphoric acid esters (PAPs) Nanogram Norwegian Institute for Air Research No Observed Adverse Effect Level No Observed Effect Concentration Na+/Taurocholate Cotransporting Polypeptide Organic anion transporters Organic Anion Transporting Polypeptides p-perfluorous nonenoxybenzenesulfonate Octamer Motif-Binding Factor 1 Organisation for Economic Co operation and Development Organisation for Economic Co-operation and Development / United Nations Environment Programme Global P Powdered activated carbon filter Perfluoroalkanoyl fluoride Polyfluoroalkyl Phosphate Esters Perfluoroalkane sulfonyl fluorides Perfluorobutane Sulfonyl Fluoride Persistent, bioaccumulative and toxic Physiologically based toxicokinetic Polychlorotrifluoroethylene 1,1,2-Trifluoro-2-(pentafluoroethoxy)ethene Perfluoroalkoxyl polymer Perfluoroalkyl iodides Per- and Polyfluoroalkyl Substance Perfluorobutanoic acid Perfluorobutyl-phosphonic acid; (Nonafluorobutyl)phosphonic acid Perfluorobutane Sulfonic acid Perfluoroalkyl Carboxylic acid Polyfluorocarbons Perfluorodecanoic acid perfluoroalkyl dicarboxylic acid perfluoroalkane disulfonic acid Perfluorododecanoic acid perfluorodecylphosphonic acid perfluorodecane sulfonic acid Perfluoroether alkanes perfluoroether acids Perfluoroalkylether carboxylic acids perfluoro-4-(ethyl)cyclohexanesulfonate Perfluorodiethyl ether; Perfluoroethyl ether; 1,1,1,2,2-Pentafluoro-2-(pentafluoroethoxy)ethane Pentafluoroethyl-phosphonic acid; Perfluoroethyl phosponic acid; (Pentafluoroethyl)-phosphonic acid Polyfluorinated ether sulfonate, perfluoroalkylether sulfonic acid Perfluoroalkyl ether sulfonic acids pefluoroethane sulfonic acid perfluoroheptanoic acid Perfluroheptadecanoic acid perfluoroheptane sulfonic acid Perfluorohexanoic acid perfluorohexadecanoic acid; perfluorohexylphosphonic acid Perfluorohexane sulfonic acid Perfluorodimethyl ether; Perfluoromethyl ether; Trifluoro(trifluoromethoxy)methane; Trifluoromethyl-phosphic acid; Perfluoromethyl phosponic acid; (Trifluoromethyl)-phosphonic acid Perfluorononanoic acid Perfluoro-3,5,7,9-butaoxadecanoic acid Perfluoro-3,5,7,9,11-pentaoxadodecanoic acid Perfluorooctanoic acid Perfluorooctadecanoic acid Perfluorooctadecanoic acid PerfluorooctylPhosPhonic acid Perfluorooctane sulfonic acid Perfluorooctane sulfonamide Perfluorooctane sulfinic acid Perfluoroalkylphosphonic acids Perfluoropentanoic Perfluoropentadecanoic acid Perfluoropentane sulfonic acid Perfluorophosphinic acids Perfluoropentyl-phosphonic acid; (Undecafluoropenty)lphosphonic acid Prefluoropropanoic acid Perfluropropane sulfonic acid Perfluoroalkane sulfonic acids Perfluoroalkane sulfinic acid Perfluoroalkane sulfinic acids Perfluorotetradecanoic acid Perfluorotridecanoic acid Perfluoroundecanoic acid Perfluoroalkyl acids 1,1,2-Trifluoro-2-(trifluoromethoxy)ethene Polyfluoroalkylalkylether acids Polyfluoroalkyl acids Persistent Organic Pollutants Perfluorooctanesulfonyl fluoride Overall environmental persistence Peroxisome Proliferator-Activated Receptor 1,1,1,2,2,3,3-heptafluoro-3-[(trifluorovinyl)oxy]propane perfluorpropylvinylether Polytetrafluoroethylene Polyvinylidene fluoride Pregnane X-recePtor Quantitative Structure-Activity Relationship Risk Assessment Committee Root Concentration Factor Risk Management Measures Bis(2-{ethyl[(perfluorooctyl)sulfonyl]amino}ethyl) hydrogen phosphate Short-chain, Shorter chain

Stippen en pompoenen De heilzame kunst van Yayoi Kusama D5 aar maandag 26 april 2021 Nationaal www.standaard.be ` Na overleg met Schepen van Jeugd Nabila Ait Daoud richten we deze brief aan u.

Thank you very much for participating and for your useful contributions.

Draft agenda for PFAS-RESTRICTION WEBEX Meeting between DE, DK, NL, NO, SE CA and ECHA 26 October 2020, 9:00 - 11:30 (CET) Login details: See below Point 1 - Opening and adoption of the agenda (9:00-9:10 am) Point 2 - Minutes and action points (9:10 - 9:20 am) 2020-10-20_PFAS RESTR-9 Minutes and APs_Draft of FINAL.docx 2020-10-20_Continued list of APs and their status.docx Point 3 - Status of COM/ECHA restriction on firefighting foams and relation with our work (9:20- 9:50 am) Maybe general discussion about the alignment with other PFAS restrictions Special attention to waste Point 4 - Status update WP1 (9:50 - 10:10 am) RMOA Discussion of draft RMOA template Discussion of possible restriction options (examples from previous restrictions) Call for evidence follow-up Information on Webinar 29 October Status on planning of stakeholder meetings and co-ordination Point 5 - Status update WP4 (10:10 - 10:30 am) All Member States to give an update on their/consultants work on the different subuses Outstanding issues Point 6 - Status update WP2 (10:30 - 10:40 am) Point 7 - Status update WP3 (10:40 - 10:50 am) Update from ECHA on status of sending output of HH hazard screening Point 8 - Status update WP7 (10:50 - 11:00 am) Point 9 -- Feedback from RiME+, 21/22 okt (11:00 -- 11:15 am) Informing group offeedback and discussions during RIME Point 10 --Action points, next steps & meetings (11:15-11:30 am) Requestfrom Chemicalwatchfor participation in webinar 3/12 Next WebEx meeting: November 23 WebEx Details ECHA Risk Management invites you to join this Webex meeting.

open open Note 1: Provide information regarding all the PFAS and/or group of PFAS that the company uses.

24 May 2023 Alliance for Telomer Chemistry Stewardship Alliance for Telomer Chemistry Stewardship's Response to the Public Consultation on Restriction Proposal on all PFAS Part I -- General Information Requests Contact Person: Shawn Swearingen, American Chemistry Council E-mail: @americanchemistry.com 24 May 2023 Contents Introduction ...................................................................................................... 1 General Information Requests ........................................................................ 1 1.

CSRRT: NIPPON KAIJI KYOKAI Class' TYPE APPROVAL CERTIFICATE Certificate No.

stopper Figure Applications and use areas of Fluoropolymer films