CORNING Hazleton EER MUTAGENICITY TEST ON 7 { NOY C5 153 }\ T6342 No, #4 sf JcoL MEASURING CHROMOSOME ABERRATIONS IN HUMAN WHOLE BLOOD LYMPHOCYTES WITH A CONFIRMATORY ASSAY `WITH MULTIPLE HARVESTS EINALREPORT AUTHOR Hemalatha Murli, Ph.D.

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----- FEHR J46-373B.F bout:raat 3M SPECIALTY ADHESIVES & CHEMICALS ANALYTICAL LABO(0R0A0T8O11R7Y6.4 2 ) To: Leo Gehlhoff- (309727) -3M Chemicals - 236-24-01 Request #'s 53030 ARI 0561) Erom: Tom Kestner - (3-5633) SA&C Analytical Lab - 236-2B-11 Subject: Fluorochemical Isomer Distribution by "*F-NMR Spectroscopy Date: December 1, 1997 SAMPLE DESCRIPTIONS: OO * FC-95, lot # 217 (T-6295); Nominal product = CsFy7-SOx(-) K(+) INTRODUCTION: `cTohnicsesnatrmaptlieonwsaosftsuhbejefcltueodrotcohaem'icFa-lNiMsoRmesrpescatnradl analysis as many omtehtehroiddetnotidfeistbelremiimnpeutrhietyidceontmiptoiensenantds raeslative possible EXPERIMENTAL: (pArFep5poar3rt0ei3odn0oth.fe4tswh0aea1msp)slaeamcpfqlouerirasenoaldliduysswiisansaagntdoVtsaalhrleiyaadnlisUsosNoaIlcTvqeYudiprlienudDsaM4nS0dO0p-lFodTtgt-eaNdnMtdhRethNsepnMecaRt3ro7smp6eeMtcetHrr.uzm.AFid-aNRMobRbisnpsectrum RESULTS: fTihueor"ocFh-emNiMcaRlsipseocmterrusmawnadsthurseeedottohedretiemrpmuirnietythceomidpeonntietnitessianntdhireslastaimvpelceo.ncTehnterqautailointsaotifvtehaendnominal quantitative summarized cionmTpAosBiLtiEo-n1alornestuhletsfowlhliocwhinwgerpaegdee.rived from the single trial F-NMR spectral analysis are `AyocuohpayvoefatnhyeqNueMstRisonpsecatbrouumttahnedsetNheMsRpercetsrualltas,sspilgenamseentlestdmaetakpnaogwe.arIeaatptoalocghiezdeffoorrytohuerderelfaeyreinnce.

UppRe FyI-0600-/378 ID DuPont Haskell Laboratory ue36293 Eleoniroat 7--0--.8--0----co Now0a 1000 AR 23G - 0573 May 25,2000 % Yt MU.r.S.ChEanrvliersonMm.enAtuaelr,PrDoitreeccttioorn Agency Office of Chemical PCoolnlturtoilonDiPvriesvieonntion & Toxics 401 M Street, N.W. -- Room 403 Dear Mr.

AR 226 . 0689 BIODEGRADATION (BOD/COD) TEST SUBSTANCE Identity: ArefmeirxrteudretocaonstPaiFnOiSn,g pFeCr-f9iu5o,roorocatsanaescuolmfopnoanteen,twhoifcFhC-m2a0y1.al(s1o-be Octanesulfonic acid, (CAS #2795-39-3) perfiuoroalkyl sulfonate salts (5) + (5140F)) Remarks: is FC-201.

ARRAZG -- O746 ACTIVATED SLUDGE RESPIRATION INHIBITION TEST TEST SUBSTANCE Identity: ArefmeirxrteudretocaonstPaiFnOiSng, pFeCr-f9l5u,oroorocatsanaescuolmfponoanteen;tmoafyFaCl-s2o0b3eC a1,n1d,2L,-25,434,03.,4,(41,-5O,c5,t6a.n6e,s7u.l7f,o8n,i8c,8a-chiedp,tadecafiuoro-, potassium salt, CAS # 2795-39-3) Remarks: The 3M production lot number L-5440.

FToam DuDanwen 0SmaA cpkesoinAoA nE8W2o1n2@0P O00P1o0n1tAMCovi RamseyAEPort@DAPon, in Suit Sme AAmmoDunAmot,- LoCcraagedSa aanets oru 4.

: AR226~1673 AIR QUALITY DISPERSION MODELING ANALYSIS OF C8 EMISSIONS DuPont Fayetteville, North Carolina Facility Prepared by: Charles J.

Toxicological Summary AR226-1746 PFOS Dietary Acute Northern Bobwhite Study Test Substance: Perfluorooctanesulfonate (PFOS) Structure: 1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-, potassium salt, CAS# 2795-39-3 Remarks: The test substance is a white powder (3M lot #217).

BACK BIODEGRADATION TEST SUBSTANCE Identity: Remarks: Perfluorooctanoic acid, ammonium salt; may also be referred to as PFOA, PFOA ammonium salt, Ammonium perfluorooctanoate, FC-116, FC-126, FC-169, or FC-143.

3M Medical Department Study: T6316.1 3M Medical Department Study: T-6316.1 Analytical Report: FACT-TOX-001 LRN-U2103 Analytical Report: FACT TOX-001 LRN-U2103 Study Title 104-Week Dietary Carcinogenicity Study with Narrow Range (98.1%) N-Ethyl PerfluorooctanesulfonamidoEthanol in Rats Analytical Laboratory Report Title Determination of the Presence and Concentration of PFOS, PFOSA, PFOSAA, EtFOSE-OH, M556, and PFOSEA in Serum and Liver Samples of Crl:CD@(SD)IGS BR Rats Exposed to N-Ethyl PerfluorooctanesulfonamidoEthanol Data Requirement Not Applicable Author 3M Environmental Laboratory Study Completion Date JuAntes0ig6n,in2g001 Performing Laboratories Liver and Serum Analyses 3M Environmental Laboratory Building 2-3E-09, 935 Bush Avenue St.

FINAL REPORT PROTOCOL 418-028 ORAL (GAVAGE) COMBINED REPEATED DOSE TOXICITY STUDY OF T-7706 WITH THE REPRODUCTION/DEVELOPMENTAL TOXICITY SCREENING TEST SPONSOR'S STUDY NUMBER: T-7706.1 FINAL REPORT DATE: 31 JULY 2003 PROTOCOL 418-028 - ORAL (GAVAGE) COMBINED REPEATED DOSE TOXICITY STUDY OF T-7706 WITH THE REPRODUCTION/DEVELOPMENTAL TOXICITY SCREENING TEST SPONSOR'S STUDY NUMBER: T-7706.1 TABLE OF CONTENTS SUBJECT 1.

PFOS: A REPRODUCTION STUDY WITH THE NORTHERN BOBWHITE FINAL REPORT WILDLIFE INTERNATIONAL, LTD.

AR226-1994 k..

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