A Pharmacokinetic Study of Potassium Perfluorohexanesulfonate in the Cynomolgus Monkey Southern Research Institute Study ID: 9921.5 April 22,2003 Final Report on A Pharmacokinetic Study of Potassium Perfluorohexanesulfonate in the Cynomolgus Monkey To: 3M Corporation P.O.

STUD TITLE ExtractionofPota`AsnsailyusmisPeUrsfilnugorHoPoLcCt-aEnelseucltfroonsaptreafyr/oMmas`sQuSaiplecSterroummetarnyd Quail Liver for DRAETQAUIREMENTS Analytical Method Requirements STUDY DIRECTOR Sean Gallagher STUDYCOMPLETEDON September 06, 2001 PERFORMINGLABORATORY / TESTINGFACILITY.

- 3M l, P.. =~ or ERBuna KSeetiefk oe nD, Enmmne Hb ana 9To0ph Ave, Buin 65336 255775 AR2ZEI7YS Certified Mall tz owe FEMQ-040S-00373 PPT 05APR2S CMBIIICE: h MR SH5T5T7TE Document Processing Center ESPAiEottaP-aes Rtoosot somn6P42r8 eAtvtn:eaSnencdttTiioonos8(ns) U[SEPrA iam-- `Washington DC 20460-0001 Noch GONTAIN NO cBl CON RE: TSCA 8(E) SUPPLEMENTAL SUBMISSION: `Sulfonate-based and Carboxylic`based Flurochemicals, Docket Nos.

AR226-2174 DISPERSION MODELING PROTOCOL Fluoropolymers Plant-APFO Emissions DuPont Washington Works Prepared by: Debbie J.

AR226-2598 I ^ I I REVISED GROUNDWATER FLOW I MODEL DUPONT WASHINGTON WORKS I WASHINGTON, WV I I I "') * I Date: January 2003 I Project No,: 18983635 7423 I I I CORPORATE REMEDIATION GROUP An Alliance between DuPont and URS Diamond I Bariey Mill Plaza, Building 27 Wilmington, Delaware 19805 I w ASH020280 EID630708 I I I I I I tKSKjjl 'tW ",'' '|I I I I I I I I Revised Qroundwater Flow Modal _______________________Introduction TABLE OF CONTENTS 1.0 Introduction,-................................"..--.---..--...............................,,,.,...--..................,3 2,0 Site Setting, Geology, and Hydrogeology.................................................................. 4 2.1 Site Setting..........,,..................................,,....,,...,,,,,,.----................,,,,.,,.,,---- 4 2.2 Geology................................,.....................................--.-....----.------.--.---4 2.3 5 Hydrogeology.............................................................................................. 3.0 Primary Data Sources....................,...,...........,..,.......,,.............................,,........----. 7 4.0 Model Set-up................................................................................................. 9 4.1 Model Domain and iMscredzation................................................,,,,...........-- 9 4.2 Boundary Conditions ....,,,,...,,.....,,,,...,,.----..............,,,,.,,,........--.--............ 10 4.2-1 No Flow Boundaries ,,.,,,,...,,..,,.,,.....,,,,...........,,.........,,,,,,,,................ 10 4.2.2 Ohio River..................................................................................... 10 4.2.3 Minor Surface Water Features.................................................... 12 4.2.4 Pumping Wells................................................................................. 13 4.3 Main Input Values......--.........,........................,,..............-...........--.............. 16 4.3.1 Hydraulic Conductivity ............................................................ 16 4.3.2 18 Recharge.............................................................................. 5.0 Groiffldwater Model Calibration ..,,.,,................,,...,......,,...,,..,--.............................. 19 5.1 Calibration Strategy....................................................................................... 19 5.2 Calibration Results................................................................................. 20 6,0 Model Results.....,.,.........,.............,.,,.,.,,.-.-.-...................,..........----................2l 6.1 MassBalaflce...,............................,........,,,.,.--................,.,..,...--"..--..............21 6.2 Current Pumping Conditions........................................................................... 21 6.3 No DuPont Pumping.......................................................................... 22 6.4 No GE Pumping.............................................................................................. 23 6.5 No Pumping by DuPont or GE................................................................. 23 6.6 No Little HocldngWA Pumping......................................................... 23 7.0 Sensitivity Analysis....................,.,.,.,,.,,.,,..................................--....--.................... 25 8.0 Model Conclusions.......,..,.,,,,.--.........................................--....--..----...--...,,,.".26 9.0 27 References..............,.......,,.,.....-- .........,,...,,........,,.,,,,..,,..............,,..,,,,--...-..--.. 74Z3WWGWM-R01^oo Jan. 7.03 Wllmlnglon, DE ASH0202B1 EID630709 Revised Oroundwaier Plow Model Introduction TABLES Table 1 Primary Data Sources for the Gtoundwater Flow Model ,..,,., ...7 Table 2 Finite-Difference Grid Vertical Discretization .................. ...9 Table 3 Table 3.

sep LOI Meeting, February 6, 2003 [acdfesbertny |otbrieco [Dave Ruesr |Durony SE WAFR2T PH 2:45 Arase-- 1300 |vorcoyvr]rasrenseansyom ms@ende Jseogorous [souwense@us.oummr.co|m i lotrSpnaeTM 1cae | sen |siehecopae | (TakaykMekambra [Eos Gonem \orsesw tease]#is-365-9578 2ndkendra da don-amevica.con [Drwid 07205vod Coton this dpc cor| 1 LOI Meeting,February 6, 2003 [ob Row -- [/oeprrpkea]eor-o6-g5h bloJey u eimogo. v| [gree frie|77 Fes x ose mdeepost | Miee Greahioro> [Riporlay (Beko) [se 290z 5 |- Myecenwosd @ roping com " 8 EPA LOI Discussion 5 February 6, 2003 | 3 | Agenda * Review Potential Routes of Exposure * EPA Input/Discussion * Next Steps?

9 pp AR226-1531 Environmental Toxicology and Chemistry, Vol. 22, No. 1, pp. 196-204, 2003 2003 SETAC Printed in the USA 0730-7268/03 $12.00 .00 BIOCONCENTRATION AND TISSUE DISTRIBUTION OF PERFLUORINATED ACIDS IN RAINBOW TROUT (ONCORHYNCHUS MYKISS) JONATHAN W.

T ons R Comparative Molecular Biology Title: of Perfluorooctancsulfonamide (FOSA, T- 7132) in Rats following four consecutive daysof dosing.

BACK TO MAIN PFOS: A 96-HOUR TOXICITY TEST WITH THE FRESHWATER DIATOM (NaviculapeZZicuZosa) FINAL REPORT WILDLIFE INTERNATIONAL, LTD.

3M Lifetime Drinking Water Health Advisory for Perfluorooctanesulfonate -.

FINAL REPORT ONE GENERATION REPRODUCTION STUDY OF PFOS - MEVALONIC ACID/CHOLESTEROL CHALLENGE AND NOEL INVESTIGATION IN RATS SPONSOR'S STUDY NUMBER: T-6295.25 FINAL REPORT DATE: 16 DECEMBER 2002 TITLE - ONE GENERATION REPRODUCTION STUDY OF PFOS - MEVALONIC ACIDKHOLESTEROL CHALLENGE AND NOEL INVESTIGATION IN RATS ARGUS STUDY NUMBER: 4 18-018 SPONSOR'S STUDY NUMBER: T-6295.25 TABLE OF CONTENTS SUBJECT PAGE I.

NORTHERN KENTUCKY OFFICE SUITE 340 1717 DIXIE HIGHWAY COVINGTON, KENTUCKY 41011-4704 606-331-2838 513-381-2838 FAX: 513-381-6613 DAYTON, OHIO OFFICE SUITE 900 110 NORTH MAIN STREET DAYTON, OHIO 45402-1786 937-228-2838 FAX: 937-228-2816 ROBERT A.

AR226-2000 :C-63 RV-3/&t EStUUSNCtltSoft E.

AR226-2115 "ntr---".'"""

AR226-2177 Dupont - Washington Works - C8 Project NOTES from Site Inspection Chris Arrington and Dave Roberts August 9,2001 10:00 a;m. - 3:00 p.m.