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: AR226-1919 H18636: Slide Reviewofpancreas lesions fram DuPont APFO Study DateofReview: 28 November 2001-11-29 Reviewing Pathologists: Dr EE McConnell and DrIR Foster Study No: HN-18636 SWyt1u4d,y6T4i3tl.e: Combined Chronic Toxicity/Oneogenicity Study with Linuron, C8 end Conclusionofthe review: th"eThierfoivnerdailnlgsc.onTclhuesiroenvoifewthceonrfeivrimeewod fthtehcetarwcoinsotguedniiecs ewfafesctthoaftAtPheFyOweirnethneotDiunPcoonnstisstteundty in awnads tchoensmiodsetreHdike0lbyeeaxdpelacnraetaisonedforstehensJiactkioffvointthyaencdoegveenleotpimceneftfoefctpofaAnPFcO raacietnhaaere3tfMfeiscttcsu,dy sctoumdbyisnheodwweidtthhaenfuulnldesrp-ercetprourmotnfgoAfPFthOe-iancdinuacrehdypaecripnlaarspiraotlhiafterwaatisonpsrefsrenotm. hyTpheerpDluasPioant tahsroaurgefhlteoctciaonrocfinionmaad.eqIutsahcoyuilndtbheenoorgtiendatlhtinttehrepcroetmamtieonnotfotnuesntuddyeburtrmeerepilsyonroretfiltenctitesnntdheged. . yefaacrtsthsatiknnotwhlcee3deMge,santdwdaiusscrriedmpionratytedi.onAoffhienaslecsuobtlne pfanciroerafttimicsalcesotinocnilsu,sohiaonsnadavwaanictesdaimnotrhee exteasive reviewofthe pancreas slides from the 3M study to be carried out by Dr McComnell.

AR226-1914 DuPont Global PFOA Strategy Comprehensive Source Reduction Presentation to EPA January 31, 2005 Company Sanitized Contains No TSCA CBI Purpose Present a comprehensive risk management approach for PFOA based on source reduction - DuPont commitment - Global impact - Voluntary actions - Work in progress for some elements - Open dialogue with EPA on this approach Page 2 January 31, 2005 Company Sanitized Contains No TSCA CBI Topics for Discussion Comments on overall approach to mitigation?

AR226-1910 13p Ongoing PFOA Worker Study Ammonium Perfluorooctonoate: Cross-Sectional Surveillance of Clinical Measures of General Health Status Related to a Serum Biomarker of Exposure and Retrospective Cohort Analyses in a Polymer Production Plant 1 What...

Ae226-1918 --c A CHARLES RIVER COMPANY PATHOLOGY PEER REVIEWREPORT ZBWEEK CAPSULETOXICITY STUDYWITHAMMONIUM PERFLUGROOCTANGATE Co(vAaPnFcOe)SItN uCyYNNOuMmbOeLrG6U3S26M.O2N9KEYS osuEcTvE E Aeicusecopairetetsenvtnvdofatnhnatceu hesoosmosaflonHg(d0oSsTe na il1,57s5e0lecwtoesdLpornatoomtond.isTh,e iyofsrl OT ars R724 MATERIALS AND METHODS Toe sic faom aae ssaesafcoo tmsal(aOnanarlssetafvtdooOyGTrovRu)po4w, streleoctemd nGreoups1 eanirmala, anaaris re0 spuosser SR) SE Wt Ag nn 5, FEED the determination of the cause of moribundity for the Group 4 animal (105724).