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AR226-1523 FINAL REPORT RECEIVED OPPT NCIC 03 SEP 30 PM1:00 PROTOCOL 418-028 ORAL (GAVAGE) COMBINED REPEATED DOSE TOXICITY STUDY OF T-7706 WITH THE REPRODUCTION/DEVELOPMENTAL TOXICITY SCREENING TEST SPONSOR'S STUDY NUMBER: T-7706.1 FINAL REPORT DATE: 31 JULY 2003 PROTOCOL 418-028 - ORAL (GAVAGE) COMBINED REPEATED DOSE TOXICITY STUDY OF T-7706 WITH THE REPRODUCTION/DEVELOPMENTAL TOXICITY SCREENINGTEST SPONSOR'S STUDY NUMBER: T-7706.1 TABLE OF CONTENTS SUBJECT 1.

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^2Z&~ l72(p Determination of Possible Interference of Perfluorooctane Sulfonic Acid Potassium Salt with Rat Cholesterol Date: 8/17/99 Study: 6329 263 Serum Vehicle Blank Blank 0 ug/mL 0 ug/mL 1.08 mg 3.23 mg 6.46 mg /mL_______/mL_____ /mL mg/dL #1 mg/dL #2 mg/dL #3 68 66 66 65 67 66 66 65 65 65 65 65 66 66 65 mean s.d. 66.33333 65.66667 65.66667 65.33333 65.66667 1.527525 0.57735 0.57735 0.57735 1.154701 Method Principle (Trinder reaction) Cholesterol esters present in serum or plasma are hydrolyzed qualitatively in to free cholesterol and fatty acids by microbial cholesterol esterase.

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Interim Report #2 Epidemiology, 220-3W-05 Medical Department 3M Company St.

3 FLUOROCHEMICAL SUBMISSION 2005 Click a Month back to year menu TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE February April June August September October

Larry R.

WATER SOLUBILITY (BY ANALYSIS OF TOC) TEST SUBSTANCE Identity: Perfluorooctanesulfonyl fluoride; may also be referred to as POSF, or FX-8. (1-Octanesulfonyl fluoride, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-, CAS #30735-7).

ACTIVATED SLUDGE RESPIRATION INHIBITION TEST SUBSTANCE Identity: Perfluorooctanesulfonylamido(ethyl)acetate; may also be referred to as PFOSAA, FC-128 or as the major component of FC-127, FC-129, FC-109, or FC-109-X.

O R iU crO sn MICROBIOS MICROTOX TOXICITY TEST TEST SUBSTANCE______________ Identity: Perfluorooctanoic acid, ammonium salt; may also be referred to as PFOA ammonium salt, Ammonium perfluorooctanoate, PFO, FC-116, FC-126, FC-169, FC-143 or as the major component of FC-118.

CAS Number 754-91-6 3M Company M 6_T77 Voluntary Use and Exposure Information Profile Perfluorooctane sulfonamide I.

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AJP003593 AR226-1988 BEST COPY AVAILABLE $9 "K. y x. > ~Q4 4- *k a V ^a l"ur I- o -a 4- 4" s dj i i: ?