AR226-1894 Reproductive Effects of C8 James Dahlgren, MD Pamela Anderson-Mahoney, PhD November 2004 Reproductive Hormones Male C8 Workers Increased PFOA Levels Lower Testosterone Prolactin Higher Estrogen Prolactin if high alcohol intake Health Study in Residents Near a Large C8 Source Methods 301 fem ales and 296 m ales with docum ented P F O A -E xp o su re >. 0.05 ug/L in drinking w ater standardized questionnaire SEER prevalence data were used for com p arison Demographics for Residential Study Participants A ge C ategory 20 - 34 35 - 4 4 45 - 54 55 - 64 65 - 80 G ender M ale Fem ale R ace/E thnicity W hite African Am erican Others Education Level L e s s th a n 9 th g r a d e 9 1 1 grade 12 lh/ V o c a t i o n a l / S o m e C o lle g e College Graduate N o. 105 104 135 154 80 284 294 558 6 9 17 59 430 65 /o 18.17 17.99 23.36 26.64 13.84 49.13 50.87 97.38 1.05 1.57 2.98 10.33 75.31 1 1.38 Demographics for Residential Study Participants a w-- t i H T i ~-i'll-- nHiMTinrin iiiiMi iii 'iWMiii[ T M "T rrfigrtB n'iii[iririT r-T '-g ^ ,;^ No. ' B ody M ass Index U nderw eight (<23) A verage (23 - 28) O verw eight (>28 ) 106 190 276 % 18.53 33.22 48.25 Sm oking Status N ever smoked S m o k e d less th a n 15 y e a rs S m o k e d m o re th an 15 y ears 252 60.58 72 17.31 92 22.12 W ork H istory Plant 1 Plant 2 N o plant w ork 54 9.42 19 3.32 500 87.26 Reproductive Cancers in Residents Near a C8 Source CANCER TYPE U terin e/C ervical Breast Prostate Number of Cancers 9 5 9 Observed R ates3 (per 100,000) 3,061 1,701 3,169 Expected R atesb (per 100,000) 96 1,579 1633 PR 33.12 1.12 1.96 C lc 1 7 .0 3 -6 4 .4 1 * 0 .4 6 -2 .7 1 0 .9 8 -3 .9 2 Uterine/Cervical Cancer in Residents Near a C8 Source Age Category 20-29 30-39 40-49 50-59 60+ # of C a n ce rs 0 2 2 3 2 N P R P-value 34 0 - 38 56.40 0.0002 64 25.02 0.0008 84 34.18 0.00001 74 31.83 0.0005 Total 9 294 Age at Menopause in Residents Near a C8 Source Age By Category 38 U .S .

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AR226-2112 Sample Date Range Concentration Range Action Level Industrial H ygiene 1/1/84 12/31/84 100% Sample Dt Sample# Duration Type Employee Name BTO: 08 TEFLON LOC: 701 FINE POWDER DRYER-EAST SIDE#2 1/8/84 46247 390 Z 1/13/84 46248 380 Z 3/11/84 46249 360 z 4/10/84 46250 395 z 5/7/84 46251 380 z 6/3/84 46252 380 z 7/2/84 46253 360 z 7/30/04 46254 360 z 8/24/84 46255 330 z 9/23/84 46256 420 z 10/21/84 46257 360 z 12/17/84 46258 370 z Pers Chemical C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 Cone Unit Percent 82 MPB 146429%** 0.19 MPB 339% 0,31 MPB 55.4% OZI MPB 379% 0.47 MPB 839% 0.29 MPB 51.8% 0 .0 3 MPB 5.4% 0.26 MPB 509% QJ53 MPB 94.6% 0.62 MPB 110.7%** 056 MPB 64.3% 0.39 MPB 69.6% BTO: 08 TEFLON LOC : 702 FINE POWDER DRYER CONTROL ROOM (ALSO SEE TTF031 1/23/84 3656$ 345 z C-8/FC-143 1/27/84 36587 420 z C-8/FC-143 2/20/84 36568 360 z C-8/FC-143 3/17/84 36569 360 z C-8/FC-143 6/12/84 36570 385 z C-8/FC-143 7/8/84 36571 340 z C-8/PC-143 8/4/84 36572 420 z C-8/FC-143 10/2/84 36573 360 z ' C-8/FC-143 11/2484 36574 350 z C-8/FC-143 12/23/84 36575 340 z C-8/FC-143 0.62 MPB 0.51 MPB 038 MPB 0.37 MPB 0.S3 MPB 0.15 MPB 0.38 MPB 0.77 MPB 0.26 MPB 0.23 MPB <1 110.7%** 91.1% 679% 66.1% 94.6% 26.8% 67,9% 137.5%** 46.4% 41.1% BTO!

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AR226-2200 EID 384430 Current Permit/Applicatlon/PDF #_________ 1823A 8150 8150 1353A Pre-Existing 614A 614A 781 1953 2365A Note: For some vents the surfactant rate is less than the total particulate reported in Air Em issions Inventory which can Include polymer dust.

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C harles J Zarzecki 02/24/2003 02:43 PM To: Catherine A Barton/AE/DuPont co: Subject: Slid e s Cathie, Here they are.

AR226-2376 I.

------------ -- AR226-2470 1/25/00 DRAFT Responses to GE questions made by Dale VanDeVelde on 1/5/00. 7) C-8 storage and use history Dupont Fluoroproducts began the use o f Ammonium Peifluorooctanoate, C-8, in the early 1950's.

AR226-2668 RECYCLED AR226-2668 Particle Size Distribution of PFOA in Ambient Air Data Summary and Analysis May 2004 Prepared for DuPont Fluoroproducts Washington Works 8480 Dupont Road Washington, WV 26181 Prepared By DuET - Reaction Engineering DuET - Environmental Engineering SUMMARY A sampling program was conducted to evaluate the particle size distribution (PSD) of PFOA in ambient air at the Washington Works site.

Katherine E.

AR226-2751 Copies to: L ,,, . . .