AR226-1750 PFOS: A PILOT REPRODUCTION STUDY WITH THE NORTHERN BOBWHITE FINAL REPORT WILDLIFE INTERNATIONAL, LTD.

AR226-1751 STUDY TITLE Extraction of Potassium Perfluorooctanesulfonate from Quail Serum and Quail Liver for Analysis Using HPLC-Electrospray/Mass Spectrometry DATA REQUIREMENTS Analytical Method Requirements STUDY DIRECTOR Sean Gallagher STUDY COMPLETED ON September 06, 2001 PERFORMING LABORATORY / TESTING FACILITY Centre Analytical Laboratories, Inc.

3M FLUOROCHEMICAL SUBMISSIONS February, 2002 - May, 2004 INDEX OF 3M'S 2002-2004 AR-226 DOCKET SUBMISSIONS BY DATE Back to Menu DECEMBER 2002 Click on Study Title to View Report December 16, 2002 December 16, 2002 Submission Cover Letter Biodegradation Study Report: Biodegradation Screen Study for Telomer Type Alcohol, Pace Analytical Services, Inc.

3M FLUOROCHEMICAL SUBMISSIONS February, 2002 - May, 2004 INDEX OF 3M'S 2002-2004 AR-226 DOCKET SUBMISSIONS BY DATE Back to Menu January 2004 Click on Study Title to View Report January 8, 2004 January 8, 2004 Submission Cover Letter Final Report, PFOA: Lactational and Placental Transport Pharmacokinetic Study in Rats, DuPont Haskell Laboratory Project No.

3M Company Page 1 of 121 FINAL REPORT Epidemiology, 220-3W-05 Medical Department 3M Company St.

Estrous Cycling and Natural Delivery/Litter Observation Data FI Estrous Cycling Data, From Data Analysis Presented at EPA on August 30,2002" APFO Dose Group (mg/kg/day) 0 1 3 10 30 All 4-Day 14/30 19/29 9/30 15/29 15/30 Cycles 3-5 Day Cycles 24/30 26/29 21/30 25/29 27/30 Cycle Length (Days) 2 3 4 5 6 7 8 Mean Cycle Length (Days) S.D. 1 2 75 18 5 1 2 4.3 0.8 Incidence of Cycle Length Per Group 0 1 80 16 2 1 0 4.2 0.5 5 7 57 32 5 0 1 4.3 0.9 2 5 84 14 3 0 0 4.1 0.6 5 5 86 17 0 0 2 4.1 0.8 Aberrant Cycles Parental > 4 Days Diest. 2 1 14 1 > 3 Days Est. 17 13 15 16 13 FI > 4 Days Diest. 5 3 3 5 3 > 3 Days Est. 25 25 29 11 14 P E M D End in Estrous Distribution of Cycle Status at Start of 21-Day Evaluation Period, FI 14 12 8 10 11 14 6220 15 13 16 13 Distribution Rats in Estrous at End of 21-Day Evaluation Period, FI 13 17 18 19 5 11 2 12 19 Mean Implantations, Liveborn, and Stillborn S.D. per Litter by Group c Parental Litters Implantations 15.3 1.9 15.6 2.1 15.2 2.3 15.6 2.0 15.3 2.0 Liveborn 14.2 2.2 14.2 2.6 13.4 3.6 13.8 3.0 13.4 3.3 Stillborn 0.1 0.3 0.4 1.4 0.2 0.4 0.1 0.4 0.2 0.6 F I Litters Implantations 14.8 3.0 15.8 2.1 14.7 2.8 15.0 2.9 14.5 2.9 Liveborn 13.6 2.9 13.7 2.4 13.8 3.0 13.5 3.1 13.3 2.8 Stillborn 0.2 0.5 0.2 0.5 0.2 0.6 0.2 0.5 0.1 0.2 "Original analysis counted cycles from the day following estrous (or proestrous if diestrus followed proestrous without observation of estrous) to the day following the end of the next estrous.

/IRVi- BIODEGRADATION TEST SUBSTANCE Identity: Perfluorodecanesulfonate, ammonium salt; may also be referred to as PFDS, FC-121-X, or 3M Sample E2112 and E2566-1. (1Decanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heneicosafluoro-, ammonium salt, CAS # 67906-42-7) Remarks: Test sample is a mixture of the test substance in water and 2propanol, 1-(1,1-dimethylethoxy).

/IR tf -O 1 BIODEGRADATION (BOD/COD/TOC) TEST SUBSTANCE Identity: Perfluorooctanoic acid, ammonium salt; may also be referred to as PFOA ammonium salt, Ammonium perfluorooctanoate, PFO, FC116, FC-126, FC-169, or FC-143.

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The miracles o f science 05FEB-9 AH!!

Katherine E.

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AR226-2236 Henry's Law Constant for C-8 in Water Henry's Law fo r a component in water is a useful approximation of the partial pressure of that component above a specified composition in aqueous solution, in its most general form, the equation that defines Henry's Law is where /j = Pure component fugacity of component 1 Hx = Henry's Law Constant for component 1 x t = Liquid phase mole fraction of component 1 Henry's Law is fundamentally valid only as x1 -> 0 and fo r ideal solutions, but is commonly used as an approximation tool at low concentrations.