AR226-1523 FINAL REPORT RECEIVED OPPT NCIC 03 SEP 30 PM1:00 PROTOCOL 418-028 ORAL (GAVAGE) COMBINED REPEATED DOSE TOXICITY STUDY OF T-7706 WITH THE REPRODUCTION/DEVELOPMENTAL TOXICITY SCREENING TEST SPONSOR'S STUDY NUMBER: T-7706.1 FINAL REPORT DATE: 31 JULY 2003 PROTOCOL 418-028 - ORAL (GAVAGE) COMBINED REPEATED DOSE TOXICITY STUDY OF T-7706 WITH THE REPRODUCTION/DEVELOPMENTAL TOXICITY SCREENINGTEST SPONSOR'S STUDY NUMBER: T-7706.1 TABLE OF CONTENTS SUBJECT 1.

P M X S rO H 0 <\ MICROBIOS MICROTOX TOXICITY TEST TEST SUBSTANCE Identity: Perfluorooctanesulfonylamido(ethyl)acetate; may also be referred to as PFOSAA, FC-128 or as the major component of FC-127, FC-129, FC-109, FC-109-X or R1904.

Corporate Occupational Medicine 3M Center, Building 220-3W-05 St.

A R fc -o !

3M Specialty Materials p - 'f f May 30, 2000 3M Center F a r - o b o o - /St.

%%' 0 O H (* ) 19:37 000112022608163 l D I C K A N S A I R & D IRD POl/O hk.Q.6- 06H-JL .Dainippon Ink & Chemicals, Inc 59200011-3 Takasago Takaishi-shi Facsimile Transmission 0sskilapa" NAME ............................Ms.

"Roger J.

3M General Offices 3M Center St.

Attachment II DuPont Statistical Analysis of Serum Lipid Data of Miteni Workers Confidential DuPont Draft Work Product Confidential DuPont Draft Work Product Confidential DuPont Draft Work Product LO G _LD L vs LO G _PFCV\ : 2 0 0 4 3. s.s 3.4 Slcpe p --m lu e LOG_P FOA = Q 02 5.5 $.2 t * S.1 m ft D O"u*1A*i1 J 4.z 4.7 4.44.5 4.4 4.5 4.2-1 .* * dI Z3 LPE-FfM LDG _LDL vs LO G _PFC A : 2 0 0 3 3.4 S.S Slope p --m lue LOS PFOA = 0.83 S.2 S.1 * 3.3 a 4.4 U 3 44 ^ 4.7 4.4 4.4' p V 4.4: 4,41 0 IZ3 L&E.FFDA 4 * 4 L O G _ L D L v s L O G _ P F Q fli : 2 0 0 2 3.1- 5.5- 3.7' Slope p--value LOG_PFCA = 0.07 5.5- 5.53.45.3- 5.1- , wm a r m . 3 5,0t.4.5 4.7 4.5 4.54.44.3- 1 * 1 1 ' ill"1 p * p i s -l -1 4 1 Z i 10C-PFM .* P * ft 45 L O G _ L D L v s L O G _ P F Q fli : 2 0 0 1 5.*- 5.3Slope p --value LOG PFCA = 0 .6 4 5.Z- * * mm m . m 3.1: 3.D o 4 .$ 1 3+5: 4.7: 4 .

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Tesffi.esuks ,, ; * % AR226-2129 file:///C|AVINDOWS/TEMP/RD C -81-3-79 thiu 4-30-811 pageitm 10f 2 T est R esu lts Sample Dale Range Concentration Range Action Level Industrial Hygiene 1/3/79 100% 4/30/81 Sample Dt Semple # Duration Type Employee Name Per* BTO : LOC : 17 RESEARCH 019 WEIGH AND ADD 0 8 TO POLYKETTLE 1/3779 47531 Z 1/4/79 47S32 Z Chemical Cone Unit Percent 0 8 <0.05 PPM 0.0% 0 8 <0.05 PPM 0.0% BTO : LOC : 17 RESEARCH 065 PPD SEM IW O RKS 4/6/81 57356 Z 0 8 <0.0001 PPM 0.0% BTO: LOC : 17 RESEARCH 100 P/S - EPM W AREHOUSE - FORK TRUCK OPERATION 4/30/81 60221 Z 0 8 0.0001 PPM 0.0% BTO: LOC : 17 RESEARCH 103 P/S FP POLLYKETTLE OPERATOR (17LG) 1/19/79 48192 Z 1/26/79 48193 Z 11/11/80 31069 P none 11/12/80 31070 P none 11/15/80 31071 P none 11/17/80 31072 P none 11/18/80 31073 P none 0 8 0.05 PPM 0.0% C-8 <0.01 PPM 0.0% C-8 <0.0001 PPM 0.0% 0 8 0.0005 PPM 0.0% 0 8 0.0005 PPM 0.0% 0 8 <0.0001 PPM 0.0% 0 8 <0.0001 PPM 8/28/2001 5:07PM E ID 129294 AJP0G6927 */ Test&?

AR226-2227 ,/?

AR226-2481 Roger J Zipfel 11/08/2000 02:35 PM To: sham rockl @wirefire.com cc: Subject: Results from extraction studies Jeff, I just got the results of m y extraction stud ies.

AR226-2643 SHI AR226-2643 --92SS0''' PROJECT 1200000GW SAMPLING 8/02 GW SAMPLING 8/02 GW SAMPLING 8/02 GW SAMPLING 8/02 202000GW SAMPLING 8/02 GW SAMPLING 8/02 201000GW SAMPLING 8/02 GW SAMPLING 8/02 212000GW SAMPLING 8/02 GW SAMPLING 8/02 SRCNAME THEME DATESMPL SMPLT WELL1 Groundwater 8/6/2002 FS WELL10 Groundwater 8/6/2002 FS WELL2 Groundwater 8/6/2002 FS WELL3 Groundwater 8/6/2002 FS WELL4 Groundwater 8/6/2002 FS WELL5 Groundwater 8/6/2002 FS WELL6 Groundwater 8/6/2002 FS WELL7 Groundwater 8/6/2002 FS WELL8 Groundwater 8/6/2002 FS WELL9 Groundwater 8/6/2002 FS SAMPLE_NUMBER SH-WELL1 SH-WELL10 SH-WELL2 SH-WELL3 SH-WELL4 SH-WELL5 SH-WELL6 SH-WELL7 SH-WELL8 SH-WELL9 TOP BOTTOM FILTERED T T T T T T T T T T CASNO 3825261 3825261 3825261 3825261 3825261 3825261 3825261 3825261 3825261 3825261 ANALYTE FC-143 FC-143 FC-143 FC-143 FC-143 FC-143 FC-143 FC-143 FC-143 FC-143 RsItPost 306000 698000 697000 31700 243000 1540000 RsItVal UNITS 1200000 NG/L 306000 NG/L 698000 NG/L 697000 NG/L 202000 NG/L 31700 NG/L 201000 NG/L 243000 NG/L 212000 NG/L 1540000 NG/L Hit LAB_ANALYTE 1 FC-143 1 FC-143 1 FC-143 1 FC-143 1 FC-143 1 FC-143 1 FC-143 1 FC-143 1 FC-143 1 FC-143 QUAL EPA QUALJNHOUSE REVIEW METHODNO 01M-008-046 01M-008-046 01M-008-046 01 M-008-046 01 M-008-046 01 M-008-046 01 M-008-046 01 M-008-046 01M-008-046 01 M-008-046 AR226-2643 C8 results Envista 111104.xls Page 1 PREPMTHD PREPREP DRY LAB NUMBER RSLTMOD RESULT UNIT MDL PQL DUPNO None NS 1 L33570-1 1200000 NG/L 500000 1 None NS 1 L33570-10 306000 NG/L 50000 1 None NS 1 L33570-2 698000 NG/L 500000 1 None NS 1 L33570-3 697000 NG/L 500000 1 None NS 1 L33570-4 202000 NG/L 50000 1 None NS 1 L33570-5 31700 NG/L 5000 1 None NS 1 L33570-6 201000 NG/L 50000 1 None NS 1 L33570-7 243000 NG/L 500000 1 None NS 1 L33570-8 212000 NG/L 50000 1 None NS 1 L33570-9 1540000 NG/L 500000 1 SHI C8 results Envista 111104.xls Page 2

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