_r 10 diagnose cpilI i tumors at a time when they are still confined to pelvis and highly curable. i paliehts with advanced cancer, treatment approaches are also changing, v combination chemotherapy regimens are under evaluation in clinical (rials vhich issues such as high-dose chemotherapy and dose intensity are being lied.

MEMORANDUM OF MEETING Wednesday, March 10, 1976 BETWEEN: SUBJECT: Andrew Maguire, M.C., 7th District, NJ Christopher Burdick, Legislative Aid John Walcott, Staff Steve d'Arazine, Staff Katherine Meyers, Staff Lowell Dodge, Special Counsel and Heinz J.

March 2 * 1973 Dr# Lucile Adamson, Staff Scientist Mr*.

Lt l t ; u > ~ > t U 4 ^ 'Lir' ) / /v J 1 "70 l 'Al .II'I'IIN IA .llll 'll NAl.

CAM-126 CONFIDENTIAL McCrone2-00648 CONFIDENTIAL McCrone2-00649

CAM-153

CAM-163

Safety Data Sheet In compliance with 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200) SECTION 1.

CAM-187 ITA-LG 00161 ITA-LG 00162 ITA-LG 00163

c f THE COSMETIC, TOILETRY, AND FRAGRANCE ASSOCIATION April 24, 2001 Dr.

CAM-298 TALC AND PYROPHYLLITE By Robert L.

HOAGIAND I0N60 MO BAN, DONS!

AMER.

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EXHIEIT V / best available copy J Paper Presented at the Metal and Nonmetallic Mine Health and 8aety Symposium on Talc Dust Hazards Held in Washington, D.C. on Tuesday, May 8, 1973 By Morris Kleinfeld, M.D., Formerly Director of the Division of Industrial Hygiene, New York State / i My former colleagues In the Division of Industrial Hygiene of Mew York State and I have had the opportunity to conduct numerous studies of talc workers in New York State, including, clinical, physiological, radiological and environmental observations^ In addition, we have also studied the mortality experiences among workers in talc mining and willing In most Instances, we have had the invaluable opportunity to correlate the clinical with the environmental data In general, we have found that sustained inhalation of significant amounts of commercial talc dust over an extended period of time, or where there was a significant lapsed time from initial exposure, can produce a synptomatic form of pneumoconiosis The commercial talc to which the talc workers were exposed contained not only the mineral talc, but also other silicates Vtrt' -- - - . ... . such as serpentine, tremolite, anthophylllte and other ingredients, predominantly carbonates* Moreover, free silica was often present in the dust in variable amounts', usually not averaging more than 3 percent Specifically with regard to our mortality experiences among talc workers, we found in an earlier study of talc workers (miners and millers) who had 15 or more years of exposure to talc dust that the proportional Mortality from carcinoma of the lung and pleura among these workers was four times that of the general population However, the significant increase In incidence of malignancy appeared in the older talc workers, namely, those in the 60 to 79 year age group, rather than in the 40 to 59 (2) year age group This observation in the talc workers was at variance with those found in a group of asbestos insulators who had the same (3) duration of exposure covering a similar time period The asbestos insulators showed an Increased incidence of mortality from lung cancer in both age categories The incidence of carcinoma of the gastrointestinal tract and peritoneum among talc workers was not significantly different Kb 2 * *% .. /' from that of the general population, whereat among the asbestos insulator* the incidence of gastrointestinal malignancy was significantly higher than that of the general population* We postulated that the earlier occurrence of malignancies among the asbestos insulators was due to two factors* The first was the relatively greater carcinogenicity of the chrysotlle asbestos as compared to commercial talc* The second factor was the exposure of the Insulators to greater quantities of chrysotile asbestos as compared to the talc workers who were exposed to lesser quantities of commercial talc dust which was admixed with appreciable amounts of tremolito and anthophyllite (2l asbestos* Our observations favored the first factor* The earlier studyv * also showed an increased incidence of deaths due to talc pneumoconiosis and/or its complications* A follow-up study was made to bring our mortality data among the talc workers up to date and to provide additional information not reported in the earlier study* The pertinent data is indicated below* All the talc workers employed in 1940 who had accumulated 15 or more years of exposure to comnereial talc dust as well as those who achieved a minimum of 15 years of such exposure between 1940 and 1969 were included in the follow-up study* The group totaled 260 workers and it is believed that the overall number constltilted the total work force in the worker population under study* The data were obtained from a number of sources* Plant records were examined and the work history of each individual was detailed to Include changes of Job and specific years of employment* Death certificates were studied in all Instances where they were available* The records of the physicians who had attended the workers privately were reviewed* Substantial medical information on the majority of the workers was available in the files of the Division of Industrial Hygiene and was used as an additional source of ITC" *-K*"* r *'~ ~n ^ / data* Hospital records, including autopsy reports end histological specimens, were examined wherever available Autopsy or biopsy records were obtained in 38 of the 108 deaths v ,r A comparison was made of the observed proportional mortality rates from the specific causes with the expected rates among similar population groups and was found satisfactory for a descriptive study of this nature The proportions of observed mortality attributed to cancer of the lung and pleura ffid,ofvthe gastrointestinal tract and peritoneum and cardiac diseases were Compared to the expected mortalities due to the above causes in the various .groups* The expected mortality for the total group represents the pro portion, of deaths among white men in the United States due to the specific causes in the year 1955 This particular year was chosen as standard because .was the median year of death among the 108 deaths For each of the 5-year periods, the median years, namely, 1942, 1947, 1952, 1957 and 1962 were selected* ........ . . . . . . ,, .