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FIRST AMENDMENT TO EXPLORATION AGREEMENT WITH OPTION TO ACQUIRE MINING LEASE THIS FIRST AMENDMENT TO EXPLORATION AGREEMENT WITH OPTION TO ACQUIRE MINING LEASE (the "Agreement") is made and entered into as of August 3, 1979, by and between RESOURCE PROCESSORS, INC., a Georgia corporation ("Resource"), and CYPRUS MINES CORPORATION, a New York corporation ("CMC").

BUU.ETXNJTO ALL jMDUSraiAL^BRANCH; J&NA une 29, 1967 FROM MAX MASON - KC SUBJECT: TALC^UNITED SIERBAJD We have entered into an agreement with United ferra Division to again market their talc and diatomite products.

JOHNS-MAIIVILLE RESEARCH AID EIIGINEERING CEIITER Ji.

DEPARTMENT OF HEALTH & HUMAN SERVICES Pubffc Health Service Eli Granek McGivney & Kluger 80 Broad Street 23rd Floor New York, NY 10004 EC - 2 2009 Food and Drug Adm inistration Rockville MO 20857 Dear Nr.

Code No.

New York University Department of Chemistry 4 Washington Flace.'

CONFIDENTIAL McCrone2-00785

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101 1 buying a pig in a poke, you have to believe in the basic 2 integrity of the thing and in the observations and all kinds 3 of things, which you never do get to check, which is sort of 4 why the robustness of the findings and anything that can 5 make it seem less dependent on day-to-day differences adds 6 to the persuasiveness for me, and the things you cited, the 7 evidence of control group, the knowledge that there is 8 quality control in the system that generated the data, all 9 those things certainly help us. 10 CHAIRMAN BUNN: For the consumers on the 11 Committee, one of the things when the FDA approves an agent, 12 it allbws a manufacturer to market or advertise, you know, 13 their product, whereas, they are not allowed to do that 14 without the FDA approval. 15 Most of the time when a company comes in with an 16 extra indication, it is because they feel it is important to 17 advertise or market, and that has been the case in the past. 18 Now we have these new things where companies are just 19 denying drugs, saying, well, the FDA hasn't approved it, 20 therefore, we are not going to pay for it, and that is an 21 unfortunate thing that I think consumers and physicians, 22 even the FDA, as we have just heard, is really not in favor 23 of that type of approach to medical care. 24 DR.

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