PLAINTIFFS EXHIBIT WCD-224 departm ent of h ealth , education , and w elfare PIJDLIC HEALTH S ER V IC E POOD AND DRUG ADM INISTRATION W A S H I N G T O N .

MEMORANDUM D E P a R T M ENT OF HEALTH, EDUCATI ON, A N D WEI.FAK l'JLC H i'.'.LTH .SI.'

PLAINTIFFS EXHIBIT WCD-247 O cto b er 5 , *$&?

JOHN TOW ER TEXAS Q J C n x ic b Pieties Jenale W ASHINGTON, D.C. 3(010 t o iM r r n u i A^MId StlWicU O *I*MAN H o u s im *. a n d January 25, 1984 Mr.

% PLAINTIFFS FEOXRHIBIDITENNTOIF,.I&CA~TIOPN6 ^ ^ 7 /PRO DUCT'DATA 7*23 LO MICRON TALC fR.C.)* * k, am--.

Mortality Study of Talc Miners and Millers Giovanni F.

.

COSMETIC TALC Minerals of Interest The asbestiforin minerals of p r i m a ry concern in regard to cosmetic talc are fibrous serpentine (chrysotile) and fibrous araphiboles (tremolite and anthophyllite)* Analytical Techniques Used at FDA The main techniques used at FDA are differential thermal analysis for the determination of serpentine minerals and x-ray diffraction for the determination of amphibole minerals.

MEMORANDUM OF MEETING August 11, 1972 : Between : FDA Representatives : Robert M.

DETERMINATION OF ASBESTOS BY OPTICAL MICROSCOPY The six kinds of asbestos can he distinguished from talc and from each other by their refractive indices, other optical crystallographic properties and morphology as determined with a polarizing- microscope.

MEMORANDUM DEPARTMENT OF HEALTH, EDUCATION, AN D WE L FARE PUBLIC HEALTH SERVICE FOOD AND DRUG ADMINISTRATION TO : DIVISION OF COSMETICS TECHNOLOGY PRODUCT COMPOSITION BRANCH ATTENTION: RONALD L.

D ETECTION OF A SBESTIFO RM A M PH IBO LE IN TALC FOR COSM ETIC USE The method for the detection of asbestiform ' amphibole in talc for cosm etic use consists of initial analysis for amphibole m inerals above the 0.5% (w/w) level, followed by characterization of the amphibole m ineral present, if any, as asbestiform or nonasbestiform by dispersion staining/optical microscopy.

CAM-35

CAM-45

CYPRUS INDUSTRIAL MINERALS TALC PRODUCTS - 1943 TO 1986 A-200 Roofing Talc Albatalc Altaic 200 USP Altaic 300 IP Altaic 325 USP Altaic 400 USP Altaic 500 USP Alliance AflgeTv^lte Aspen Aspen-EF Beaverwhlte 200 BeaverwMte 325 Brite Talc 200 Brite Talc }25 Brite Talc 400 BT 200 BT 325 C-3Q0 C-400 C-500 Cascade 200 'Cascade 325 eB Ceramic CB Ceramic 92 CB Ceramic 94 CB Ceramic 96 CB Ceramic 99 Cypruclas 20/200 Cyprufil 200 Cyprf11 325 Cypruplate Dover 50 Electrom1te-T * Electrowhite Epsta Talc Fibre White Fibrene #106 Flbrene -300, Fibrene C-400 Flbrene C-500 Ftbren Dust F1brene:Mist Fl|ntstoqe F 1prance Frisco Frisco Alliance Furnace Creek FprnacQ Creek Coarse Glacier 200 Glacier 325 Glacier 400 HMR-29 HMR-32 Huntley IS Cosmetic IS Silver , Kotabrite 55 Logeb LS Silver Mlstron 18 Mistron 25 Mlstron 139 Mistron 400 Mistron 450 Mistron 600 Mistron Cyprubond Mistron Cyprusperse UH:435-1003A;2 Mistron EG Mistron F-128 Mistron Foam Mlstron Frost Mistron HG-75 Mlstron HG0-55 .Mlstron HGO-75 Mistron Maximix Mlstron Mist Mistron Mdnomix Mlstron MSC Mistron Promix Mistron RCS jMistron RjCS #2 Mlstron Spray Mistron Star Mistron Superfrost Mistron T-076 Mistron Ultramix Mistron Vapor Mistron Vappr Compacted Mlstron Vapor Densified Mistron JSC Monarch 96 Monark Mopo.blend Monosp&n Nova NS {Cosmetic NS Silver Nucli Aid Nueli Ald-Z ; Oasis Olympic Orean Orean-Ef IAW:435-1003A 3 Panamint #10 Panamint 96 Panamint 99 PWW-200 Pyropaque Pyrgpaque7A Pyrotalc Rajah Rainbow Rogers Sierra #28 Sierra #505 Sierra Buck Sierra Cloud Sierra Cosmetic Sierra Cosmetic #10 Sierra Fibrene Sierra Hi Glow Sierra Mi Fire Sierra Higrade Sierra Higrade #1 Sierra Higrade #17 Sierra Higrade #71 Sierra Mist Sierra Rex Sierra Sagger #7 Sierra Select Sierra Snow Sierra Snow #71 Sierra Special Sierra Super Sierra Supreme 200 Sierra Supreme 325 Sierra Supreme USP Sierra Vapor Sierra White PLAINTIFFS EXHIBIT CAM-111 il LUZ00000027 Sierra White 200 Sierra White 325 Sierra White III Sierra White IR Sierra White PCP Sterrai ite .