Cyprus Industrial Minerals Company 555 South Flow er Street Los Angeles, C alifornia 90071 Telephone 213)4 8 9 -3 7 0 0 TWX 910) 3 2 i 5753 February 12, 1980 ' -Talc and the OSHA Asbestos Standard 29CFR 1 9 m m m Sssti-ssriis Morsna ^ Safety and Health Sta u d a X s ( c S t l l l T a o F w * SSA s i n w S f a e S s ?

c v . j s industrial Mirarsi Campanv Tue Prawn 7200SoumAnonW*v.

Industrial Hygiene Walk-Through Report at Cyprus Industrial Minerals Company, Van Horne, Texas '.91-131175 National Inst. for Occupational Safety and Health, Cincinnati, OM 1990 t .a. . s"9' I 7 59S Ls CAM-315 I It.

CAM-371

WCD 001633

PRODUCT NUMBER PRODUCT ORIGIN DATE L A B .

.w m V D U DEPARTMENT OF HEALT: .DUCATION, AND WELFARE PUBLIC HEALTH SERVICE CDC, National Institute for Occupational Safety and Health TO Hearing Clerk Food and Drug Administration from : SUBJECT: Director, National Institute for Occupational Safety and Health Proposed Regulation on Asbestos Particles in Food and Drugs The proposed regulation on asbestos particles in food and drugs, described in the Federal Register of September 28, 1973 (21 CFR Parts 121 and 133), has been reviewed and comments are offered.

f THE UPJOHN COMPANY K A LA M A ZO O , M IC HIG A N 49001 TELEPHONE (616) 382-4000 M EDICAL SERVICES Office of KENNETH B HAAS D V M July 13, 1976 Hearing Clerk Food and Drug Administration Room h-SS 5600 Fishers Lane Rockville, Maryland 20852 Dear Sir: In compliance with the Federal Register Notice, Volume 40, Number 51, March lA, 1975, page 11865, titled "Asbestos-form Particles in Drugs for Parenteral Injection", we are supplying the attached memo as an updated report for replacement of asbestos filters.

BOARD OF DIRECTORS Ira Arlook Judith Brady Irwin Brass, Ph.D.

Semin Oncol. 1998 Jun;25(3):255-64.

ON T3 vO vOsf <r II I Ftp-r. r v . tv .

DETECTION OF ASBESTIFORM AMPHIBOLE IN TALC FOR COSMETIC USE The method for the detection of asbestiform ' amphibole in talc for cosmetic use consists of initial analysis for amphibole minerals above the 0.5% (w/w) level, followed by characterization of the amphibole m ineral present, if any, as asbestiform or nonasbestiform by dispersion staining/optical m icroscopy.

Hon.

DETECTION OF ASBESTIFORM AMPHIBOLE MINERALS IN COSMETIC GRADE TALC Introduction The method which has been adopted for the detection of amphi bole minerals in cosmetic talc is the generally accepted method of x-ray diffraction.

*-------- -------- ------ 1 FY: 1974 DATE: 9/6/73 "-ogram: COSMETICS PPE USE ONLY 00679 # Subprogram: Aerosols & Hair Preparations rroject litle: Asbestos and Other Contaminants in Talc Project Manager 6 Mailing Symbol : John Stuart (BF-446) Statement of Obi active: Develop one or several methods of sufficient sensitivity and reliability which will permit the determination of asbestos and other contaminants in talc-containing products with the necessary degree of accuracy and at concen trations at which such contaminants present a potential health hazard. -- ------- * The inhalation of certain asbestiform minerals is a known health hazard.