Document zzLG9vNp1LyddKGL6K2806BRz

Company Sanitized. Does not contain T S C A CBt AR226-2874 Copies to r v " I' TM *nt ae Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine HASKELL LABORATORY REPORT WO. 744-78 Procfidurc s Th tst mstfirial Je a c/w intubation to a group of ten young adult ChR^CI^ma 1 repeated dosage level of 5,000 n ^ / d a v - S 2*1, Ws a<3ministered by intragastric flve^times a "eek, for two weeks at a a ? i i aiSd Y**? orn oiX* Five controls and five test ratswerf t e n . ^ ts served as controls and was 4 f:ei a 2 edisa; r dose* * remain^ 1 Results; Dose (m g/kg/davi 5,000 No. of Doses 10 Mortality 0/10 Clinical Sicms -- --: . alopecia ana Second Week; Wet and stained perineal area, stained feet, alopecia, diarrhea and weight loss Recovery Stained perineal area, alopecia, entire body stained, stained nose and mouth, weak ness and slight weight loss. Company Sanitized. Does not contain TSCA CBI # 2 .gpanary: p B B B ^ H H V w a s administered orally to young adult ChR-CD male rats at a j level of rootHn^lcg/day for ten days over a two-week period. Compound-related h i s t w ? ? dSG effects were e general failure to thrive, necrosis of her,opoieti" c i r o ? the speiS9 L n . marrow and thymus, necrosrs of gen., cells, decreased sperm production and hepatic S e c r a i ^ Toxic effects of the test material on the hemopoietic system were no lonaer annaronf 1 a * * exposure. Hepatomegaly would be expected to be completely reversible given a logr r e c o v e y ^ I o d . ** Tissues examined histologically testis, epididymis, spleen, b o n e ^ S S T ? S ! ? ^ h 5 5 ! ! S ^ 5 S ^ S E ^ T i S ^ 5 I H ^ ^ B i i P L lnK ludfd: a r g u s ? ' traChea' 1UngE' b r a i" ' St0maCh- " S TM . -- " ; i o " " a ; t a" " d U S - OLD/aph Report No. 744-78 Date Issued: December 15, 1978 Approved by: hUi.ua f , A. Michael Kaplan Chief, Acute Investigations Section