Document zdG5bL7yqzyRLmX7Z8Zom3bZg

2130 MINUTES of the two-hundred eightieth meeting of the Board of Directors of the Chemical Manufacturers Association, Inc., held at the Galleria PLaza Hotel, UUuiston, Texas, Tuesday, October 23, 1980, at 2:00 p. m. Directors: H. Barclay Morley, Chairman William G, Simeral, Vice Chairman Richard C. Ashley William G. Kay, Jr. Dexter F. Baker John Morrisroe Charles E. Brookes Paul F. Oreffice Harry W. Buchanan L. John Polite, Jr. Carlyle G. Caldwell Seymour S. Preston III Robert S. Dudley Toy F. Reid Richard E. Engebrecht William C. Roher Louis Fernandez Robert A. Roland William J. Ferracone John P. Sachs Robert W. Gerwig Harold A. Sorgenti Arthur L. Goeschel Alfred C. Stepan, Jr. James B. Henderson Allan J. Tomlinson Richard J. Hughes H. Kent Vanderhoef William B. Jackson Konrad M. Weis Leo H. Johnstone Harriette F. Witmer Emerson Kampen Louis G. Zachary Secretary: General Counsel: Treasurer: Bruce M. Barackman Edmund B. Frost Gary C. Herrman By Invitation: Warren M. Anderson, Union Carbide Corporation Geraldine V. Cox, CMA Richard F. Gold, Stauffer Chemical Company W. E. Kennel, Amoco Chemicals Corporation W. C. Krumrei, The Procter & Gamble Company James N. Sites, CMA William M. Stover, CMA 1. The meeting was called to order by Chairman Morley. 2. APPROVAL OF SEPTEMBER 8, 1980 MINUTES Minutes of the September 8, 1980 meeting, as distributed, were approved. CMA 012619 .f* V t )S IS ycic cgfl al er ina ureal Table 4.-- A Partial List of 65 Chemicals Designated as ^Priority Pollutants Arsenic Benzene Beryllium Cadmium Carbon tetrachloride Chlordane Chlorinated naphthalenes Chloroform 2-chlorophenol Dichlorobenzenes 2, 4-Dimethylphenol 2,3,7,8-Tetrachlorodibenzo-p-dioxin Fluoranthene Heptachlor Hexachlorobutadiene Hexachlorocyclopentadiene Lead Nitrosamines Pentachlorophenol Selenium Silver Tetrachloroethylene Thallium Trichloroethylene Vinyl Chloride 17 - CMA 012620 Table 6. -- Chemicals Having Substantial iviience of Carcinogenicity; CAG List 2-AcetyLaminofluorene ' Acrylonitrile iCAG. IaRC) Afiatoxins iIARC) Aldrm iCAG. NCI) 4-Ammbbiphenyl (IARC) Amitrole iIARC) *-- Aramite (IARC) Arsenic and Arsenic Compounds (CAG, LARC) Asbestos iCAG. IARC) Auramine and the manufacture of Auranune (IARC) Aiaserine CARC) 1 Benzie'acridine iIARC) 1 Benzi a'anthracene (IARC).' Benzene iCAG. IARC) Benzidine (CAG. IARC) Benzol a) pyrene (LARC) Benzolb'fluoranthene (IARC) Benzolj'fluoranthene (IARC) ' Beryllium and Beryllium Compounds (CAG, IARC) N.N'-Bisi 2-Chloroethyi)-2-Naphthylamine (Chlomapharine) i IARC) * Cadmium and Cadmium Compounds (CAG, IARC) Carbon Tetrachloride (CAG, IARC) Chlorambucil (LARC) ' Chloroalkyl Ethers Bisi 2*chioroethyl tether (BCEE) (CAG) (IARC) ' Bisichloromethyl(ether (BCME) (CAG. LARC) 1,2-Dimethylhydrazwe (LARC) Dimethyl Sulfate (IARC) 2.4-Dimtrotoluene (CAG NCI) 1.4- Dioxane t NCI) l,2.Diphenylhydrazine iCAG) Epichlorohydrtn iCAGi .* Ethylenebisdithiocarbamate (EBDC) (CAG) Ethvleneimine lAziridine) (IARC) * Ethylene Oxide iCAG, IARC) Ethylenethiourea (CAG, LARC) Ethyl Methanesulfonate (IARC) Formaldehyde (CAG) Glycidaldehyde (IARC) Heptachlor (CAG, NCI) Hexachlorobenzene (CAG, IARC) Hexachlorobutadiene (CAG) Hexachlorocyclohexane (HCH) HCH (CAG) HCH (Lindane) (CAG) Technical HCH (CAG) Chloromethyl methyl ether (CMME), technical grade (IARC) Chlordane (CAG. NCI) Chlorinated Ethanes 1.2-Dichloroethane [Ethylene Chloride, Ethylene Dichlonde (EDC)| (CAG, IARC, NCI) Hexachloroethane (CAG) 1.1.2.2-Tetrachloroethane (CAG) 1.1.2- Tnchloroethane (CAG, NCI. IARC) ` Chlorobenzilate (CAG) Hydrazine (IARC) Indeno(1.2,3-cd)pyrene 'LARC) Iron Dextran (IARC) , J Isosafroie (LARC) Kepone (Chlordecone) (CAG. NCI) Lasiocarpine (IARC, NCI) Melphalan (IARC) ' Methapyrilene (FDA) 1 3- Methylcholanthrene ' 4.4'-Methyienebis(2-ChloroaniIine) (MOCA) (IARC) Methyl Iodide (CAG. IARC) *~ Chloroform (CAG, IARC) Methyl Methanesulfonate (IARC) Chromium Compounds, Hexavalent (CAG, IARC) N-Methyl-N'-mtro-N-nitrosoguanidine (IARC) Chrvsene (IARC) 1 Citrus Red No 2 (TARO Coal Tar and Soot (CAG included in IARC's soots, tan. and oils designation) Coke oven Emissions I Polycyclic Organic Matter (POM)) (CAG) Creosote ICAG) Cycasin (IARC) Cyclophosphamide (IARC) * Daunomvcin (IARC) ` DDT (DIchlorodiphenyltrichloroetbaM) (CAG) Methyltinouraci] (IARC) Mitomycin C (LARC) Mustard Gas (LARC) 1- Naphthylamine. technical grade (CAG) 2- Naphthylamine (IARC) Nickel and Nickel Compounds (CAG. IARC) Nitrogen Mustard and Us hydrochloride (IARC) Nitrogen Mustard N-oxide and its hydrochloride (IARC) 5-Nitro-o-toluidine (NCI) 4- Nitroquinoline-l-oxide1 Nitrosamines Diailate (CAG) (IARC) ` N-Nitrosodiethanolamine (IARC) I Dibenz(a.h)acridine (IARC) N-Nitrosodiethvlamine (DENA) (CAG. IARC) Dibenzi a.j)acridine (IARC) N-Nitrosodimethvlamine (DMNA) (CAG, IARC) Dibenzia.hianthracene (LARC) N-Nitrosodi-n-butylamine (IARC) ?H-Dibenzo<c.g)carbazole (IARC) N-Nitrosodi-n-propvlamine (IARC) ?H-Dibenzo(c.g)cartazole (IARC) N-Nurosomethvlethylamme iIARC) Dibenzoia.eipyrene (IARC) N-Nitrosomethylvinylamine (IARC) Diben2o(a.hipyrene (LARC) N-Nitroso-N-Ethylurea (NEU) (CAG. IARC) Dibenzo(a.i (pyrene (IARC) N-Nitroso-N-Methylurea (NMU), (CAG. IARC) 1.2- Dibromo-J-chloropropane (DBCP) (CAG. IARC, NCI) N-Nitroso-N-methylurethan# (IARC) 1.2- Dibromoethane (Ethvlene Bromide, Ethylene N-Nitrosomorpholine (IARC) Dibromide (EDB)| <NG. CAG, IARC) N-Nitrosonomicotine (IARC) 2, T-Dichlorobenzidine (DCB) (CAG. IARC) Dieldrm (CAG) N-Nilrosopiperidine (IARC) N-Nitrosopyrroiidine (IARC) Diepoxybuune (IARC) N-Nitrososarcosine (IARC) 1.2- Diethylhydraxine (IARC) Pentachloromtrobenzene (PCNB) (CAG) Diethylsulbestrol (DES) (IARC) * Phenacetin (IARC) ' Dihydrosafrole (IARC) Polychlorinated Biphenyls (PCBl) (CAG. IARC) 3.3' Dimethoxybenzidlne (o-Dianisidine) (IARC) Pronamide (CAG) P-Dimethylaminoazobenzene (IARC) 1.3-Propane Sultone (IARC) I.12-0imethylbenz(a)anthr>cene 1 ,* Propiolactone (IARC) 2.3` Dimethyibenzidine (o-Toiidine) (IARC) Dimethylcarbamoyl Chloride (IARC) 1.1-Dimeihylhydrazine (IARC) Propylthiouracil (IARC)' Reserpine (NCI) Sacchann (FDAi 1 CMA 012621 Safrole (CAG. IARC) Selenium Sulfide (NCI) Streptozotocin (IARC) ' 2.3.7,3-Tetrachlorodibenio-p-<Uoxin (TCDD) (CAG) Tetrachloroethylene (Perchloroethylene) (CAG, NCI) Thioaceumide (IARC)Thiourea (IARC) o-Toluidine Hydrochloride (NCI) Toiaphene (CAG, IARC, NCI) Trichloroethylene (CAG. NCI) 2.4.6-Trichiorophenol (NCI) Tris( 1-aziridinyl (phosphine sulfide (Thio-TEPA) (IARC, NCI) ' Tris( 2.3-dibromopropyl(phosphate (IARC, NCI) Trypan Blue, commercial grade (IARC) Uracil Mustard (IARC) * Urethane (IARC) (Ethyl carbamate: ethyl ester of car- bamic acid) Vinyl Chloride (CAG. IARC) Vinylidene Chloride (CAG) 1 This is not a comprehensive list of all diemicais having substan tial evidence of carcinogenicity. Other chemicals will be added. No attempt has been made to select chemicals based upon ippropnateness (or regulation by EPA. The list is intended to be a basis (or selection by the various program offices according to their specific needs. ` Weil known carcinogen for which no report has been prepared b* CAG or IARC. 1 Fungal toxin, not an industrially manufactured product ` Used as a drug. ` Evaluated by IARC as not having sufficient evidence of car cinogenicity. 1 Used as a foood. - 22 - CMA 012622 Table 7. --- Alphabetical Index of Chemicals Cited in the -NTP Annual Plan Acetamide 25 Acetin 25 Acetohexamide 36 2-Acetyl aminofluorene 40 4-Acetyl aminofluorene 40 N-Acety1 aminof1uorene 40 Acetyl-o-toluldine 25 Acetylsalicyclic acid 36 Acid black 42 Acid orange #3 42 Acid red 25 68 Acrolein 25 Acrylamide 70 Agar agar 42, 55 Agaritine 42 Aldicarb 36, 5, 62 Ally! chloride 51 Ally! Isothiocyanate 42 Allyl Isovalerate 42 2- Aminoanthraqulnone 36. 51 3- Am1no-9-ethylcarbazole hydrochloride 51 3-Am1no-a,a,a-tr1fluoroto1uene 25 1-Amino-2-methylanthraqulnone 51 2- Am1no-4-n1trophenol 42 2-Amino-5-nltrophenol ' 42 - 23 - CMA 012623 Tris (2,3-dibromo propyl) phosphate 67 Trls M.3-dlchlorolsopyl) phosphate 67 Tris(2-ethylhexyl)phosphate 32, 50 Tris(Isopropylphenyl)phosphate 34 - 0- Tritolyl phosphate 32 p-Tritolyl phosphate 32 1- TryptOphan 38 Urethane 40 Vitamin A 74 Vinyl chloride 65 Vinylcyclohexane 50 Vinylcyclohexene dioxide 61 Vinylldene chloride 1, 27, 50, 56, 60 Vinyl toluene 50 Violet 3 50 Wollastonite calcium silicates 34, 59 Witch hazel 50 m-Xylene 32, 73 o-Xylene 32, 73 p-Xylene 32. 73 Xylenes, mixed 59, 72, 73 Xylenesulfonlc acid, sodium salt 50, 61 2.6-Xylldlne 61 Yellow #14 50, 56 Zearalenone 50 Zlram 50, 56 - 46 - CMA 012624 Technical Director o CMA ~Ththalate Esters Finylidene Chloride I. .. I FIGURE 1. Organisation of Biomedical and Environmental Soecial Proorams i cm 10/B/BO TABLE 8 BICMEDICAL AND HNVIRCMttNIAL SPECIAL FRCGRAMS HJDGET* PROGRAM . Acrylonitrile Allyl Chloride Benzene Butylated Hydroxytoluene Chlorobenzenes Epichlorohydrin Epoxy Resins Ethylene Dibromide Ethylene Dichloride Glycol Ethers RESEARCH AND ADVOCACY commitment $ 728,484 210,600 1,430,444 21,944 300,972 . 214,882 --0TM 10,000 288,100 -0- ADMINISTRATIVE EXPENSES $ 59,411 13,948 83,526 25,213 22,334 27,332 9,368 28,836 59,376 -0- TOTAL $ 787,895 224,548 1,513,970 47,157 323,306 242,214 9,368 38,836 347,479 -0- Ketones -0- 10,901 Phosgene 207,912 55,035 Phthalate Esters 106,471 72,086 Rubber Additives 27,900 5,867 Styrene 708,218 54,934 Titanium Dioxide 30,725 14,615 Trichloroethylene 490,506 77,152 Vinyl Chloride 1,326,562 112,958 Vinyl idene Chloride 729,482 52,088 Zinc Dialkyl Di thiophosphates -0- -0-- Subtotal 6,833,202 784,983 Fluorocarbons 7,580,453 509,214 TOTAL $14,413,655 $1,294,197 aFluorocarbons program from start thru May 30, 1980. All other prograns start to Septentoer, 1980. 10`,901 262,947 178,557 33,767 763,152 45,340 567,658 1,439,520 781,570 -0- 7,618,135 8,089,667 $15,707,352 bAPI is co-sponsoring a portion of this research. Its share ($1,587,786) is not shown in this figure. The figure does include $303,388 paid to outside legal counsel rot shown on the program sunmary in Appendix A. - 48 - CMA 012626 9/22j