Document zDnxpYj39jXDXjyqokZR2qLa

M k k _ Ul NORTHERN KENTUCKY OFFICE SUITE 340 1717 OIXIE HIGHWAY COVINGTON. KENTUCKY 41011-470* 606-331-283* 613-381-283* FAX 313-381-6613 Roberta. Bilott (513) 357-9638 biiottQtaftlaw.com TAFT, STETTINIUS & HOLLISTER LLP 1800 FIRSTAR TOWER 425 WALNUT STREET CINCINNATI, OHIO 45202-3957 313-381-2838 FAX: 513-381-0208 wyrw.taftlaiM.coin April 12,2002 CERTIFIED MAIL NO. 7000 1670 0009 4961 7412 RETURN RECEIPT REQUESTED IRIS Submission Desk c/o ASRC 6301 Ivy Lane, Suite 300 Greenbelt, MD 20770 CLEVELAND OHIO OFFICE 3600 BP TOVCR 200 PUBLIC SQUARE CLEV6LAN0, OHIO 44114-2302 216-241-2838 FAX 216-241-3707 COLUMBUS. OHIO OFFICE 21 EAST STATE STREET COLUMBUS. OHIO 43215-4221 814-221-2838 FAX614-221-2007 e=> LT-8** 0^0 *-X"O) cj-n> cn --1If*] Tpm o p n 73C o d "77 ro Re: IRIS Submission Inventory for Perfluorooctanoic Acid - Ammonium Salt (CAS No. 3825-26-1)_________________________________________ IRIS Submission Desk: On January 9, 2002, a notice appeared in the Federal Register that the United States Environmental Protection Agency was soliciting additional information with respect to an upcoming IRIS evaluation of the referenced chemical "for effects from acute and subchronic exposure, in addition to chronic exposure." Although USEPA requested initial submission inventory information by March 11,2002, USEPA stated in its January 9,2002, Federal Register notice that "the public may submit information on any chemical substance at any time." (67 Fed. Reg. 1214 (Jan. 9,2002).) The undersigned is class counsel for those who have asserted claims against E.I. duPont de Nemours and Company ("DuPont") in West Virginia State Court arising from contamination of human drinking water supplies with ammonium perfluorooctanoate (a/k/a "C-8"). In connection with that litigation, the undersigned has received, among other things, copies of the documents relating to the health and environmental effects of C-8 referenced on the attached lists. It is possible that DuPont or the 3M Company may claim confidential business information protection with respect to some of the referenced documents. OO6O0S LE 1755 t IRIS Submission Desk April 12, 2002 Page 2 Please contact the undersigned at the address, telephone number, and e-mail address referenced above for any questions regarding any of the information referenced on these lists. Thank you. Robert A. Bilott RAB/mdm Attachments: 1. C-8 Human Health Risk Evaluations; 2. C-8 Human Heaith/Epidemiology Studies; 3. C-8 Animal/Toxicity Studies; and 4. C-8 Environmental Impact/Distribution Studies. ooooec LE 1756 C-8 ANIMAIJTOXICITY s t u d ie s 1961 1962 1965 1966 1968 1976 1977 DuPont, Internal Memo Re Toxicity of Teflon Dispersing Agents (11/9/61) DuPont Haskell Lab, Acute Oral Toxicity of C-8-APFC/FC-143 Rats (11/8/61) DuPont, Summary of Toxicity Studies on Fluorocarbon Dispersing Agents in Dogs and Rats (1962) DuPont, Pathogenic Action Following Repeated Oral Administration of C8APFC (FC-143) in Male CRCD Rats (2/9/62) DuPont, Pathogenic Action Following Single Oral Administration of C8APFC (FC-143) in Male CRCD Rats (2/14/62) DuPont, Effect of Fluorocarbon Dispersing Agents on the Livers of Rats and Dogs (8/19/65) Clayton, W.J., The Mammalian Toxicology of Organic Compounds Containing Flourine (Pharmacology of Fluorides, (Frank A. Smith, Ed.) (1966) DuPont, Memo Re: Bioassay Results from the Philadelphia Academy of Natural Sciences Concerning Toxicity of C-8 and Triton Discharges to Ohio River (10/18/66) DuPont, Haskell Lab., Acute Oral Test of APFO in Male CHRCD Rats (6/13/68) DuPont, Haskell Lab., Acute Inhalation Dust Toxicity of APFO in Rats (6/17/68) Biosearch, Inc., Primary Eye Irritation Study - Rabbits (for 3M) (3/4/76) Biosearch, Inc., Primary Skin Irritation Study - Rabbits (for 3M) (3/4/76) Biosearch, inc., Acute oral Toxicity - Rats (for 3M) (3/4/76) Bionetics/Litton., Ames Salmonella/Microsome Assay (for 3M) (12/20/77) 000007 LE 1757 1978 1979 1980 3M Env. Lab., IRDC 137-088; FM-3422/Monkey Tests (8/16/78) E.G. & G. Bionomics, Summary of Histopathological Examinations of Fathead Minnow Exposed to 78:03 (FC-143) for 30 days (for 3M) (9/78) Int'l Res. & Devel. Corp., 90-Day Subacute Rat Toxicity Study; Fluorad FC-143 (for 3M) (11/6/78) Int'l Res. & Devel. Corp., 90-Day Subacute Rhesus Monkey Toxicity Study; Fluorad FC-143 (For 3M) (11/10/78) Schneider, P.W., DuPont Haskell Lab. Memo Re: 3M's Fluorad Fluorochemical FC-143 Toxicity Studies (3/5/79) Steiner, C.E., DuPont Memo Re: C-8 Communications Meeting - Outline, Talk & Charts (7/31/80) DuPont Haskell Lab., Inhalation Subacute: APFO (Albino Male Rats) (7/20/79) \ DuPont Haskell Lab., Skin Irritation Test on Rabbits: FC-143 (10/5/79) DuPont Haskell Lab., Eye Irritation Test in Rabbits: FC-143 (10/5/79) DuPont Haskell Lab., Skin Absorption LD50-Rabbit and Rat: FC-143 (10/26/79) Ophaug, R.H. and Singer, L., Metabolic Handling of PFOA in Rats. 163 Proceedings of Soc. for Exp. Biol. Medic. 19-23 (1980) Griffith, F.D. and Long, J.E., Animal Toxicity Studies with APFO. 41 Am. Ind. Hyg. Assoc. J. 576-583 (1980) Riker Lab., Absorption of FC-143 in Rats After A Single Oral Dose (for 3M) (1/17/80) 3M Env. Lab., Aquatic Toxicity Testing: FC-143 (Fathead Minnows) (5/8/80) DuPont Haskell Lab., Skin Absorption LD50-Female Rats: FC-143 (9/22/80) DuPont Haskell Lab., Rat Skin Absorption Subacute Study With FC-143 (Male CHR-CD Rats) (10/10/80) 00009* . i. LE 1758 3M Env. Lab., Daphnid Bioassay: CS-2151 (2/5/81) 3M Env., Lab., Oral Rangefinder Study of T-2998C0C (APFO) in Pregnant Rats (3/12/81) Univ. of Minn. (Env Pathology Lab), An Assay of Cell Transformation and Cytotoxicity in C3H 10T 1/2 Clonal Cell Line for the Test Chemical T-2942 COC (for 3M) (3/4/81) DuPont, Haskell Lab., Subacute Inhalation Toxicity of Pentadecafluorooctonoic Acid, Ammonium Salt in Rats (4/15/81) DuPont, Haskell Lab., Oral LD50 Test in Guinea Pigs (6/1/81) DuPont, Haskell Lab., Oral LD50 Test in Rats (6/1/81) DuPont, Haskell Lab., Oral LD50 Test in Mice (6/17/81) 3M Env. Lab, Acute Effect of CS-2151 on Microbial Respiration (8/24/81) DuPont, Haskell Lab., Oral Acute Toxicity Comparison Test in Rats (9/29/81) DuPont, Haskell Lab., Oral LD50 Test in Rats (9/30/81) DuPont, Haskell Lab., Liver Weight Comparison in Castrated and Ovariectomized Rats vs. Normal Rats (10/7/81) DuPont, Haskell Lab., Mouse Feeding Study - 14 Day (10/26/81) DuPont, Haskell Lab., APFO Blood Levels in the Female Rat (12/7/81) 3M Company, Oral Teratology Study of T-2998C0C (C8/FC-143) in Rats (as amended 12/15/81) DuPont, Haskell Lab., The Effects of Dowex Ion Exchange Resin on the Toxicity ofC-8 in Rats (12/31/81) 3M Env. Lab., Multi-Phase Exposure/Recovery Algal Assay Test Method (FC143) (11/16/81) 000009 -3LE 1759 Kennedy, G.L., DuPont Interim Report: Acute Toxicity of Perfluorocarboxylic Acids (1/11/82) Kennedy, G.L., DuPont Interim Report: Evaluation of Sex/Species Differences in Response to C-8 (1/11/82) DuPont Haskell Lab., C-8 Gavage: Embryo-Fetal Toxicity and Teratogenicity Study in the Rat (1/14/82) DuPont, Haskell Lab., C-8 Inhalation: Embryo-Fetal Toxicity and Teratogenicity Study in the Rat (1/14/82) DuPont, Haskell Lab., FC-143 Occluded Skin Test on Rabbits (1/28/82) Riker Labs., Oral Teratology Study of T-3141C0C in Rabbits (for 3M) (2/23/82) DuPont Haskell Lab., 14-Day Feeding Study in Male and Female Mice (3/8/82) McKusick, B.C., DuPont Memo Re: Report of FC-143 Teratogenic Studies to EPA (3/15/82) DuPont, Haskell Lab., Placental Transfer of 14C-Labfilled C-8 in the Rat (5/18/82) DuPont, Haskell Lab., Mouse feeding Study - 21 days (5/25/82) DuPont, Haskell Lab., Effect of Cholestyramine on the Elimination of APFO From Rats and Mice (9/17/82) DuPont, Haskell Lab., 14-Day Feeding Study in Male and Female Mice (10/1/82) Riker Labs, Acute Oral Toxicity Screen With T-3290C0C in Albino Rats (for 3M) (11/5/82) DuPont, Haskell Lab., Excretion and Disposition of APFO in Male and Female Rats, Mice, Hamsters, and Rabbits (11/12/82) Kennedy, G. L., DuPont Interim Report: Evaluation of Sex/Species Differences in Response to C-8 (1/14/83) 000010 -4LE 1760 1984 1985 1986 1987 DuPont Haskell Lab., Acute Oral Toxicity of FC-143 As A Function of Age in Rats (2/1/83) DuPont Haskell Lab., C-8 Liver Weights in Rats and Mice: Oral Administration To Males and Females (5/18/83) Oldon, C.T. and Anderson, M.E., The Acute Toxicity of Perfluorooctanoic and Perfluorodecanoic Acids in Male Rats and Effects on Tissue Fatty Acids. 70 Toxicol. Appl. Pharm. 362-372 (1983) Staples, R.E., Burgess, B.A., and Kerns, W.D., The Embrvo-Fetal Toxicity and Teratogenic Potential of APFO in the Rat. 4 Fd. Appl. Toxicol. 429-440 (1984) Johnson, J.D., Gibson, S. J. and Ober R.E., Cholestvramine-Enhanced Fecal Elimination of Carbon-14 in Rats After Administration of APFO or PFOS. 4 Fd. Appi. Toxicol. 972-76 (1984) DuPont Haskell Lab., Acute Oral Effects of C-8 and Ethanol in the Rat (10/8/84) DuPont Haskell Lab., Data Summary Report on Tests for Acute and Chronic Toxicity of Fluorochemicals (FC-143) to Daphnia Magna (Water Flea) (11/1/84) Ikeda, T., Aiba, K., et al., The Induction of Peroxisome Poliferation in Rat Liver bv Perfluorinated Fattv Acids. Metabolicallv Inert Derivatives of Fattv Acids. 98 J. Biochem. 475-82 (1985). DuPont Haskell Lab., Approximate Lethal Concentration by Inhalation (ALC) of APFO (6/3/85) Kennedy, G.L.. Dermal Toxicity of APFO. 81 Tox. Appi. Pharm. 348-55 (1985) Kennedy, G.L., Hall, G.T., et al., Inhalation Toxicity of APFO. 24 Fd. Chem. Tox. 1325-29(1986). Pastoor, T.P., Lee, K.P., et al., Biochemical and Morphological Studies of APFOInduced Hepatomegaly and Peroxiome Proliferation, 47 Exp. Molec. Path. 98-109 (1987) 000011 -5 LE 1761  1988 1989 1990 1991 1992 Kennedy, G.L., Increase in Mouse Liver Weight Following Feeding of APFO and Related Fluorochemicals. Tox. Letters 39 (2-3): 295-300 (Dec. 1987) Riker Labs., Two-Year Oral (Diet) Toxicity/Carcinogenicity Study of Fluorochemical FC-143 in Rats (for 3M) (8/28/87) Sykes, G., DuPont Memo. Re: Review of Two-Year Toxicity/Carcinogenicity Study of Fluorochemical FC-143 in Rats (10/29/87) Perkins, R.G., 3M Memo. Re: Summary of Review of the FC-143 Two-Year Feeding Study Report to be Presented at 1/7/88 Meeting With DuPont (1/5/88) DuPont Haskell Lab., DuPont Memo Re: Review of APFO According to EQC Guidelines for Control of Carcinogenic and Reproductive Risks (2/29/88) Kinney, L.A., Chromey, N.C., and Kennedy, G.L.. Acute Inhalation Toxicity of APFO. 27 Fd. Chem. Toxicol. 465-68 (1989) Ylinen, M., Hanhijarui, H., et al., Stimulation bv Oestradiol of the Urinary Excretion of PFOA in the Male Rat. 65 Pharm. & Tox. 274-77 (1989) Reinhardt, C.F., DuPont's TSCA 8(E) Letter Re: APFO (9/27/89) Ylinen, M., Kojo, A., et al., Disposition of PFOA in the Rat After Single and Subchronic Administration. 44 Bull. Env. Contam. Tox. 46-53 (1990) Vanden Heuvel, J.P., Kuslikis, B.I., et al., Tissue Distribution. Metabolism, and Elimination of PFOA in Male and Female Rats. 6 J. Biochem. Tox. 83-92 (1991) Abdellatif, A.G., Preat, V., et al., The Modulation of Rat Liver Carcinogenesis bv PFOA. a Peroxisome Proliferator. 111 Tox. Appl. Pharm. 530-37 (1991) Nilsson, R., Beije, B., et al., On the Mechanism of the Hepatocarcinogenicitv of Peroxisome Proliferators. 78 Chem.-Biol. Interactions 235-250 (1991) Kuslikis, B.I., Vanden Heuvel, J.P., and Peterson, R.E.. Lack of Evidence For Perfluorodecanovl - or Perfluorooctanovl-Coenzvme A Formation in Male and Female Rats. 7 J. Biochem. Tox. 25-29 (1992) -6- 000012 LE 1762  1993 Vanden Heuvel, J.P., Davis, J.W., et al., Renal Excretion of PFOA in Male Rats: Inhibitory Effect of Testosterone. 7 J. Biochem. Tox. 31-36 (1992) Goecke, C.M. Jamett, B.M., and Reo, N.V., A Comparative Toxicological Investigation of Perfluorocarboxvlic Acids in Rats bv Fluorine-19 NMR Spectroscopy. 5 Chem. Res. Tox. 512-519 (1992) Glavert, H.P., Srinivasan, S.A., et al., Effects of the Peroxisome Proliferators Ciprofibrate and PFOA on Hepatic Cellular Antioxidants and Lipid Peroxidation in Rats. 43 Biochem. Pharm. 1353-59 (1992) Cook, J.C., Murray, S.M., et al., Induction of Levdig Cell Adenomas bv APFQ: A Possible Endocrine-Related Mechanism. 113 Tox. Appl. Pharm. 209-217 (1992) Takagi, A., Sai, K., et al., Hepatomegaly is an Early Biomarker for Hepatocarcinogenesis Induced bv Peroxisome Proliferators. 11(3) J. Env. Path. Tox. Oncol. 195-49 (1992) Vanden Heuvel, J.P., Kuslikis, B.I., and Peterson, R.E., Covalent Binding of Perfluorinated Fatty Acids to Proteins in the Plasma. Liver and Testes of Rats. 82 Chem.-Biol. Interactions 317-328 (1992) Haughom, B. and Spydevoid, O., The Mechanism Underlying the Hvpolipemic Effect of PFOA. PFOSA and Clofibric Acid. 1128 Biochem. Biophys. Acta., 6572(1992) Hazelton Wisconsin, Inc., 13-Week Dietary Toxicity Study With T-5180 APFO (CAS No. 3825-26-1) in Male Rats (for 3M) (5/17/93) Cook, J.C., DuPont Memo Re: Potentially Reportable Toxicity Data [TSCA 8(e)] Regarding C-8 (9/23/93) Zobel, L.R., 3M Letter to USEPA Under TSCA 8(e) Re: Supplemental Notice Regarding C-8 (10/11/93) Reinhardt, C.F., DuPont Draft Letter to USEPA Under TSCA 8(e) Re: 2-Year Bioassay in Rats with C-8 (10/13/93) 000013 -7LE 1763 1994 1995 Olsson, U., Sundberg, C., et al., Further Studies on the Involvement of Selenium in Peroxisome Proliferation in Rat Liver: Comparison of Effects with Clofibric Acid and PFOA and the Pharmacokinetics of Clofibrate. 46 Biochem. Pharm. 1805-1810(1993) Frame, S.R., DuPont Letter to 3M Re: DuPont Review of Pancreases of HighDose Male Rats From 3M's 2-year FC-143 Study (4/21/94) DuPont Haskell Lab., DuPont Memo Re: Available Toxicity Literature for APFO (6/1/94) DuPont Haskell Lab., Static, Acute, 96-Hour LC50 of H-19704 to Bluegill Sunfish (8/26/94) 3M Company, Assessment of the Bioaccummulative Properties of APFO: Static Fish Test (5/31/95) T.R. Wilbury Lab., Acute Toxicity of L-13492 to the Fathead Minnow, Pimephales Promelas (for 3M) (7/13/95) T.R. Wilbury Lab., Acute Toxicity of L-13492 to the Daphnid, Daphnia Magna (for 3M) (7/13/95) 3M Env. Lab., Inhibitory Effect of L-13492 to Microbics' Microtox Toxicity Analyzer System (7/26/95) 3M Env. Lab., Inhibitory Effects of L-13492 on Activated Sludge Respiration (7/26/950 T.R. Wilbury Lab., Growth and Reproduction Toxicity Test with L-13492 and the Freshwater Alga, Selenastrum Capricomutum (for 3M) (8/3/95) T.R. Wilbury Lab., Acute Toxicity of N2803-3 to the Fathead Minnow, Pimephales Promelas (for 3M) (11/16/95) T.R. Wilbury Lab., Acute Toxicity of N2803-4 to the Fathead Minnow, Pimephales Promelas (for 3M) (11/21/95) T.R. Wilbury Lab., Growth and Reproduction Toxicity Test With N2803-2 and the Freshwater Alga, Selenastrum Capricomutum (for 3M) (11/28/95) 000014 -8LE 1764  1996 1997 Biegel, L.B., Liu., R.C., et al., Effects of APFO on Levdig Cell Function: In Vitro, in Vivo, and ex Vivo Studies. 134 Tox. Appl. Pharm. 18-25 (1995) Cai, Y., Appelkuist, E-L., and DePierre, J.W., Hepatic Oxidative Stress and Related Defenses During Treatment of Mice With Acetvlsalicvlic Acid and Other Peroxisome Proliferators. 10 J. Biochem. Tox. 87-94 (1995) Fort, F.L., Miyajima, H., et al., Mechanison for Species-Specific Induction of Levdig Cell Tumors in Rats bv Lansoprazole. 26 Fd. Appl. Tox. 191-202 (1995) Filliben, T.A., DuPont Memo Re: Multiple Dose Gavage Summaries (6/21/95) T.R. Wilbury Lab., Growth and Reproduction Toxicity Test with N2803-4 and the Freshwater Alga, Selenastrum Capricomutum (for 3M) (3/7/96) T.R. Wilbury Lab., Acute Toxicity of N2803-2 to the Daphnid, Daphnia Magna (for 3M) (3/25/96) T.R. Wilbury Lab., Acute Toxicity of N2803-4 to the Dapnid, Dapnia Magna (for 3M) (3/25/96) 3M Env. Lab., Internal Memo/Charts Re: Biotransformation of PFOA (11/11/96) DuPont Haskell Lab., DuPont Memo Re: Available Toxicity Literature for APFO (12/20/96) Goecke-Flora, C.M. and Reo, N.V., Influence of Carbon Chain Length on the Hepatic Effects of Perfluorinated Fattv Acids. A 19F-ad 31P-NMR Investigation. 9 Chem. Res. Tox. 689-95 (1996) Liu., R., Hahn, C., and Hurtt, M.E., The Direct Effect of Hepatic Peroxisome Proliferators on Rat Levdig Cell Function in Vitro. 30 Fd. Appl. Tox. 102-108 (1996) Mehrotra, K., Morgenstem, R., et al., Effects of Peroxisome Proliferators and/or Hypothyroidism on Xenobiotic-Metabolizing Enzymes in Rat Testis. 104 Chem.Biol. Interactions 131-145 (1997) Clegg, E.D., Cook, J.C., et al., Levdig Cell Hyperplasia and Adenoma Formation: Mechanisms and Relevance to Humans: 11 Reprod. Toxicol. 107-121 (1997) 000015 -9LE 1765 Oboum, J.D., Frame, S.R., et al., Mechanisms for the Pancreatic Oncogenic Effects of the Peroxisome Proliferator Wveth-14. 643. 145 Tox. Appl. Pharm. 425-36 (1997) Nabberfeld, D., Butenhoff, J., et al., Displacement of a Fluorescentlv Labeled Fattv Acid Analogue From Fatty Acid Lamer Proteins bv Wveth-14. 643. APFO. PFOS. and Other Known Peroxisome Proliferators. (Presented at 1998 SOT Annual Meeting) Kennedy, G.L., Biegel, L.B., et al., Draft "Toxicology of APFO" (Draft of Manuscript dated 8/10/98) Covance Lab., Draft Abstract of Final Report for 4-Week Capsule Toxicity Study with APFO in Cynomolgus Monkeys (Unaudited Draft of 9/15/98) Pathology Assoc., Int'l, Cell Proliferation Results From Covance Study No. 6329230(9/16/98) Pathology Assoc. Int'l., Pathology Review of Reported Tumorigenesis in Twoyear Study of FM-3924 in Rats (11/25/98) Kennedy, G.L., DuPont Memo Re: Results of C-8 Monkey Study (2/24/99) 3M Env. Lab., 3M Memo Re: Preliminary Results of Wk. 26 and 27 Liver and Sera in TOX026/T-6889.2 (5/14/99) Covance Lab., Pathology Report for 6329-231 (5/19/99) Lieder, P.H., Memo to APME Subcommittee on APFO Re: Preliminary Analytical Results for C-8 Monkey Study (5/19/99) Covance Lab., Memo Re: Hormone Analyses Data for 26-Week APFO Cynomologus Monkey Study (5/27/99) O'Connor, J.C., E-mail to Kennedy, G.L. Re: Hormone Data From 26-Week APFO Monkey Study (7/16/99) Covance Lab., Internal Memo Re "Troubling" Data From Monkey Study (7/27/99) Covance lab., Memo Re: Draft Pathology Report for Study 6329-231 (8/25/99) 00001$ - 10- Thomford, P., Memo to McKee, P. Re: Hormone Summary for C-8 Monkey Study (9/8/99) Kennedy, G.L., Charts from Internal DuPont Presentation Re: Results of C-8 Monkey Study (9/27/99) Covance Lab., Revised Draft of Final Report for 26-Week C-8 Monkey Study (10/7/99) Pinchot, R., Internal DuPont E-mail Re: Results of 26-Week C-8 Monkey Study (10/22/99) Jepson, G.W., Internal DuPont E-mail Re: Summary Report on Kinetic Analysis of C-8, PFOS, Zonyl FCC and Zonyl 7950 (11/8/99) Thomford, P., Letter to Lieder, P. (at 3M) Re: Cell Proliferation Data for 26-Week C-8 Monkey Study (11/12/99) Covance Lab., Statistical Analyses of Cholecytokinin Data for 26-Week C-8 Monkey Study (11/16/99) Reed, K.E., 3M Letter to USEPA Under TSCA 8(e) Re: Substantial Risk Notice on APFO Re: 6-Month C-8 Monkey Study Results (11/19/99) Shabalina, J.G., Panaretakis, T., et al., Effects of the Rodent Peroxisome Proliferator and Hepatocarcinoeen. PFOA. on Apoptosis in Human Hepatoma Hep 62 Cells. 20(12) Carcinogenesis 2237-46 (Dec. 1999) Jepson, G.W., Internal DuPont Summary: Preliminary Kinetic Analysis of Screening Data for Chemical Solutions Enterprise Compounds, Including C-8 and PFOS (12/14/99) DuPont Haskell Lab., H-24215: Static, Acute, 96-Hour LC50 to Rainbow Trout, Oncorhynchus Mykiss (12/20/99) Habecker, P., Davis-Keller, L.D., et al., Tennant Farm Herd Health Investigation: Cattle Team Report (12/23/99) Mehrota, K., Morgenstem, R., et al.. Hvpophvsectomv and/or Pesoxisome Proliferators Strongly Influence the Levels of Phase II Xenobotic Metabolizing Enzymes in Rat Testes. 122 Chemico-Biol. Interactions 73-87 (1999) - li - 000017 LE 1767 CNTC/CCPA Endocrine Research Fund Progress Report For 1/4/99 - 3/8/2000 (with abstracts of studies) Elcombe, C., Thoughts on Enlarged Monkey Livers (Report From Univ. of Dundee Re: 26-Week C-8 Monkey Study) (3/14/00) Anilytics Inc., Letter to 3M Medical Dept., Re: Primate TSH Analysis (4/5/00) Finlay, C., Jepson, G., et al., Abstract: Development of A Mammalian Screen to Evaluate Absorption and Persistence of Fluorinated Chemicals (2000) Hinderliter, P.M., and Jepson, G.W., Abstract: Development of a Biologically Based Model to Describe PFOA Kinetics (2000) Jepson, G.W., Hinderliter, P.M., et al., Abstract: Comparison of PFOA and PFOS Blood Kinetics in Rats Following Repeated Oral Dosing (2000) Kennedy, G.L., DuPont Letter to USEPA Transmitting Summaries of APFO and PFOA Studies (5/25/00) Weppner, W.A., 3M Letter to USEPA Transmitting Information on 3M PFOA and PFOS Studies (5/25/00) Butenhoff, J., Draft: Toxicity of APFO in Cynomolgus Monkeys After 26 Weeks of Oral Dosing (Draft dated 7/28/00) Burton, J.H., A Study of the Effect of PFOA on Rumen (Cattle) Fermentation (Univ. of Guelph Study Conducted 8/23/00 - 8/31/00) Belcher, L.A., DuPont Letter Re: Section 71(1 )(b) Notice - The Toxicity of Selected Pesfluoroalkyl and Fluoroalkyl Substances (9/1/00) Pathology Assoc., Int'l., Draft Cell Proliferation Report for 26-Week Capsule Toxicity Study with APFO in Cynomolgus Monkeys (9/29/00) Rurak, D., DuPont E-Mail Re: University of Guelph Testing of PFOA for Endocrine Disruption (11/6/00) Covance lab., Draft 4-Week Capsule Toxicity Study With APFO in Cynomolgus Monkeys (Audited Draft of 11/21/00) 000018 - 12 - LE 1768 2001 Belcher, L.A., DuPont Section 71(l)(b) Notice - The Toxicity of Selected Perfluoroalkyl and Fluoroalkyl Substances (11/30/00) Biegel, L.B., Hurtt, M.E., et al., Mechanisms of Extrahepatic Tumor Induction hv Peroxisome Proliferators in Male CD Rats. 60 Tox. Sciences 44-55 (2001) Kudo, N., Suzuki, E., et al., Comparison of the Elimination Between Perfluorinated Fattv Acids With Different Carbon Chain Length in Rats. 134 Chem.-Biol. Interactions 203-216 (2001) Burton, J.H., Preliminary Report of Effect of PFOA-Contaminated Water on Cattle Rumen (Univ. of Guelph Study Conducted 1/28/01 - 1/28/01) O'Connor, J.C., An Alternative to the EDSTAC Screening Battery for Detecting Endocrine-Active Compounds. Johns Hopkins Univ. Center for Alternatives to Animal Testing Workshop. (12/4/01) Elcombe, C., Characterization of APFO-Induced Liver Growth in Cynomolgus Monkeys (Report From Univ. of Dundee Re: 26-Week C-8 Monkey Study) (2001) University of Guelph Notes Summary for 3/2/01 Meeting (3/16/01) Kennedy, G.L., Internal DuPont Chart Re: Mechanistic Studies - APFO: Pancreatic Effects (3/6/01) Burton, J.H., Report on Effect of PFOA Contaminated Water on Cattle Rumen Protozoa and Bacteria (Univ. of Guelph Study Conducted 3/8/01 - 3/12/01) Purdy, R., Charts from Presentation on Perfluoroalkanoic Acids (3/26/01) Martin, J.W., Solomon, K.R., et al., Dietary Accumulation and Bioaccumulation of Perfluorinated Acids in Juvenile Rainbow Trout (Presented at SETAC Meeting 5/01) DuPont, Internal Charts Re: Toxicology and Descriptive Biology: APFO (5/4/01) Boudreau, T.M., University of Guelph Charts Re: PFOA and PFOS Acids II: Surfactant Toxicity Towards Aquatic Plants (presented at meeting on 5/01) Ranshotyn, G., APME Letter to DuPont Attaching Copy of Agreement Between APME and DuPont to Develop a Physiological Based Kinetic Model for APFO (6/20/01) 000019 - 13 - LE 1769 Santoro, M.A., 3M Letter to USEPA Re: Additional Information PFOS and Related Compounds (6/28/01) DuPont, Acute Toxicity Bioassay Report for Washington Works, W. VA. Plant Outfall Into Ohio River (8/1/01) Butenhoff, J., et al., Draft of Manuscript: Toxicity of APFO in Male Cynomolgus Monkeys After Chronic Oral Dosing (8/31/01) Rurak, D., DuPont Letter to USEPA and WVDEP Responding to 7/24/01 Request for Information on C-8 (8/31/01) Rurak, D., DuPont Letter to USEPA and WVDEP Responding to 7/24/01 Request for Information on C-8 (9/28/01) DuPont Haskell lab., Charts Re: Status of PFOA Kinetics and Protein Binding Projects (9/30/01) Abstracts and Summaries of SETAC North America Perfluorochemicals Symposium Topics (11/12/01) Jepson, G.W., Charts Re: APME sponsored PFOA Kinetics Research Project: Interim Technical Progress Update (11/13/01) McConnell, E. E. and Foster, J.R., HI 8636: Slide Review of Pancreas Lesions From DuPont APFO Study (Reviewed 11/28/01 - 11/29/01) DuPont Haskell Lab., Protein Binding of PFOA (For APME) (12/01) C. Wilkinson, LLC, Memorandum to 3M and DuPont Re: Perfluorooctanoate Review (12/8/01) Product Safety Labs., H-24921: Dermal Sensitization Test - Buehler Method (For DuPont) (12/17/01) Covance Lab., Final Report: 4-Week Capsule Toxicity Study with APFO in Cynomolgus Monkeys (For APME) (12/18/01) Covance Lab., Final Report: 26-Week Capsule Toxicity Study With APFO in Cynomolgus Monkeys (For APME) (12/18/01) - 14- 00002# LE 1770 Moroi, Y., Yano, H., et al., Determination of Acidity Constants of Perfluoroalkanoic Acids. 74 Bull. Chem. Soc. Japan 667-672 (2001) 2002 DuPont, Overview of APFO Published and Unpublished Toxicity Literature (2001) Belcher, L.A., DuPont Letter Re: Section 71(1)(b) Notice - The Toxicity of Selected Perfluoroalkyl and Fluoroalkyl Substances (1/24/02) Cook, J.C. and Corton, C., Draft: Non-Hepatic Tumor Target Sites (Draft Chapter for Book on Peroxisome Proliferators) (Draft dated 1/9/02) Cook, J.C., Draft PFOA Case Study (Draft Chapter for Book on Peroxisome Proliferators) (Draft dated 1/9/02) DuPont, Charts from SPI/FMG Meeting with USEPA and ATSDR Re: APFO (1/30/02) Kennedy, G.L. DuPont Charts Re: APFO Toxicology & Environmental Fate and Effects (2/02) DuPont, Response to Interrogatory No. 1 of Plaintiffs' First Set of Interrogatories in Leach, et al. v. E.I. duPont de Nemours and Co., et al. (Civil Action No. 01-C-608 Wood Cty. W. Va. Cir. Ct.) (2/18/02) Argus Research, Oral (Gavage) Two-Generation (One Litter Per Generation) Reproduction Study of APFO in Rats (for 3M) (3/26/02) Sanderson, H., Boudreau, T.M., et al., Ecological Impact of PFOA on the Zooplankton Community in Indoor Microcosms (Unpublished article, Draft dated 4/02) UNDATED Butenhoff, J., Costa, G., et al., Chart Re: Toxicity of APFO in Cynomolgus Monkeys after 26 Weeks of Oral Dosing Charts Re: Toxicokinetics of PFOA (Pilot ADME Data) Jepson, G.W., Hinderliter, P.M., et al., Charts RE: Comparison of PFOA and PFOS Blood Kinetics in Rats Following Repeated Oral Dosing - 15 - 000021 LE 1771 Nabbefeld, D.J., An Investigation of the Effects of Fluorocarbons on Liver Fatty Acid-Binding Protein (Masters Thesis) Executive Summary of Assays for Cytotoxicity and Cell Transformation for T-2942 COC Using C3H 10T-1/2 Cell Cultures in Vitro Coming Hazelton, Abstract of In Vitro Assay Evaluating Ability of T-6564 to Induce Chromosomal Aberrations in Chinese Hamster Ovary (CHO) Cells With and Without Metabolic Activation Coming Hazelton, Abstract of In Vitro Assay Evaluating Ability of T-6342 to Induce Chromosomal Aberrations in Chinese Hamster Ovary (CHO) Cells With and Without Metabolic Activation Coming Hazelton, Summary of Investigation of T-6564 for Mutagenic Activity in the Salmonella-Escherichia Coli/Mammalian-Microsome Reverse Mutation Assay with a Confirmatory Assay Coming Hazelton, Summary of Investigation of T-6342 for Mutagenic Activity in the Salmonella-Escherichia Coli/Mammalian-Microsome Reverse Mutation Assay with a Confirmatory Assay Coming Hazelton, Summary of Mutagenicity Test on T-6564 in an In Vivo Mouse Micronucleus Assay Coming Hazelton, Summary of Mutagenicity Test on T-6342 in an In Vivo Mouse Micronucleus Assay Elcombe, C., Mechanisms of APFO-Induced Pancreatic Acinar Cell Tumours in Rats Chauhan, S., Criddle, C., and Tiedje, J., Evidence of Biodegradation of Trifluoroacetic Acid (funded by 3M) H:\ClassAction\C-8 Animal Toxicity Studies.wpd - 16- 000022 LE 1772 C-8 ENVIRONMENTAL IMPACT/DISTRIBUTION STUDIES 1978 1981 1984 1986 1991 3M Env. Lab, Adsorption and FC-143 on Soil (2/27/78) 3M Env. Lab, Adsorption of FC-95 and FC-143 on Soil (2/27/78) 3M Env. Lab, Biodegradation Studies of Fluorocarbons-III (7/19/78) 3M Env. Lab, Biosorption of CS-2151 (CS-2070) (8/25/81) 3M Env. Lab, Chemical Oxygen Demand of CS-2151 (8/31/81) Doughty, J.F., DuPont Memo Re: Summary of C-8 Water Sampling Program (8/29/84) Prescher, D., Gross, U., et al., Environmental Behavior of Fluorinated Surfactants Part 3: Treatment of Industrial Waste Water. 14 Acta Hydrochim. Hydrobiol. 293-304 (1986) (English Translation) Zipfel, R.J., DuPont Memo Re: Interim Report No. 2 of Univ. of Delaware Study on C-8 (10/21/91) Zipfel, R.J., DuPont Memo Re: Interim Report No. 3 of Univ. of Delaware Study on C-8 (12/5/91) DuPont, RCRA Verification Investigation Report for DuPont Washington Works (4/92) 1996 DuPont Exp. Station Lab., Aqueous Polymerization Process for Fluoropolymers: New Initiators, Surfactants, Additives and Chain Transfer Agents (2/13/96) PRC Env. Mgt., Inc., Field Trip Report: Preliminary Assessment Dry Run/N. Fork Lee Creek Bovine Site, Washington, Wood County, West Virginia (for USEPA) (12/13/96) 000023 LE 1773  1997 1998 1999 MacKav. D.. PiGuardo. A., et al,, Evaluating The Environmental Fate Of A Variety Of Types Of Chemicals Using The EQC Model. 15 Env. Tox. Chem. 1627-1637(1996) DuPont, Evaluation of the Biodegradability of C-8 Using the Modified Sturm Test (OECD 301 B) (3/11/97) Feiring, A.E., DuPont Memo Re: Microemulsion Polymerization of Fluoromonomers (5/22/97) QST Env., Inc., Chronic Toxicity of Surface Water Samples From the Dry Run Creek Site With the Fathead Minnow, Pimephales Promelas (for USEPA) (7/97) 3M Env. Lab., Results from Analyses of Soil and Groundwater Samples from the E.I. DuPont de Nemours and Company Facility in Parkersburg, West Virginia (11/13/97) USEPA Env. Response Team Center, Draft Report: Dry Run Creek Washington, Wood County, West Virginia (11/97) URS Greiner Woodward Clyde, Letter to USEPA Re: Small Mammal Trapping Effort-Preliminary Findings, Dry Run Landfill, Washington, West Virginia (12/3/98) Moody, C. and Field, J.A., Determination of Perfluorocarboxvlates in Groundwater Impacted bv Fire-Fighting Activity. 33 Env. Sci. Tech. 2800-2806 (1999) 3M Company, The Science of Organic Fluorochemistry (2/5/99) 3M Company, Fluorochemical Use, Distribution and Release Overview (5/26/99) DuPont Corp. Remed. Group, RCRA Facility Investigation Report: DuPont Washington Works, Washington, West Virginia (6/30/99) Kreamer, G-L.C. and Gannon, J., DuPont Charts Re: C-8 Ecological Risk Assessment (6/30/99) Battelle, Multi-City Study: Field Report for Cleveland, Tennessee and Decatur Alabama-Battelle Duxbury Activities (for 3M) (7/9/99) 000024 2- LE 1774  2000 2001 Berti, W.R., DuPont E-Mail Re: Estimates of C-8 in Ohio River (8/11/99) URS Greiner Woodward Clyde, Memo Re: Results of Evaluation of Staining in Shrew Teeth - Dry Run Landfill, Washington, West Virginia (10/4/99) 3M Company, Sulfonated Perfluorochemicals in the Environment: Sources, Dispersion, Fate and Effects (3/1/00) DuPont, Adsorption-Desorption Screening Studies of APFO (5/00)b DuPont, Modeling Releases of APFO Into the Ohio River (5/22/00) Geisy, J.P. and Kannan, K., Global Distribution of PFOS in Wildlife. 35 Env. Sci. Tech. 1339-42(2001) Lu, J.R., Ottewill, R.H., and Rennie, A.R., Adsorption of APFO at the Air-Water Interface. Colloids Surfaces A: Physiochemical Eng'g Aspects 183-85 (2001) Hansen, K.J., Clemen, L.A., et al., Compound-Specific. Quantitative Characterization of Organic Fluorochemicals in Biological Matrices. 35 Env. Sci. Tech. 766-70 (2001) Berti, W., DuPont Charts/Abstract Re: APFO at Washington Works and Adsorption/Desorption to Soils and Sediments (3/15/01) 3M Env. Lab., Hydrolysis Reactions of PFOA (3/30/01) 3M Env. Lab., Characterization Study of PFOA-Phase: Solubility Determination (3/30/01) Dixon, D.A., Memo Re: Fluorochemical Decomposition Processes/Degredation Pathways for Flurochemicals in Incineration Processes (by William R. Wiley Env. Molecular Sciences Lab, Pacific Northwest Lab.) (4/4/01) 3M Env. Lab., Screening Studies on the Aqueaus Photolytic Degredation of PFOA (4/20/01) Entrix, Inc., Selected Flurochemicals in the Decatur, Alabama Area (for 3M) (6/ 01) OOIN2$ LE 1775 Geisy, J.P. and Kannan, K., Accumulation of PFOS and Related Fluorochemicals in Fish Tissues (for 3M) (6/20/01) Geisy, J.P. and Kannan, K., Accumulation of PFOS and Related Fluorochemicals in Marine Mammals (for 3M) (6/20/01) Geisy, J.P. and Kannan, K., Accumulation of PFOS and Related Fluorochemicals in Mink and River Otters (for 3M) (6/20/01) Geisy, J.P. and Kannan, K., PFOS and Related Fluorochemicals in Fish-Eating Water Birds (for 3M) (6/20/01) Geisy, J.P. and Kannan, K., PFOS and Related Fluorochemicals in Oyster, Crassostrea Virginica, from the Gulf of Mexico and Chesapeake Bay (for 3M) (6/20/01) Centre Anal. Labs, Inc., Analysis of PFOS, FOSA, and PFOA from Various Food Matrices Using HPLC Flectospray/Mass Spectrometry (for 3M) (6/21/01) Centre Anal. Labs., Inc., Alfalfa Summary - FOSE Alcohol, Ethyl FOSE Alcohol, PFOS, PFOA, and PFOSA - 3M Plant - Cordova, Illinois (for 3M) (6/21/01) 3M Env. Lab., Executive Summary: Environmental Monitoring - Multi-City Study - Water, Sludge, Sediment, POTW Effluent and Landfill Leachate Samples (6/25/01) Ellis, D.A., Mabury, S.A., et al., Thermolysis of Fluoropolvmers As A Potential Source of Haloeenated Organic Acids In The Environment. 412 Nature 321-24 (7/19/01) DuPont, DuPont Lists of Public Water Systems in West Virginia and Ohio With Alluvial Wells in the Sand Formation of the Ohio River (8/30/01) Rurak, D., DuPont Letter to USEPA and WVDEP Responding to 7/24/01 Request for Information on C-8 (8/31/01) Rurak, D., DuPont Letter to USEPA and WVDEP Responding to 7/24/01 Request for Information on C-8 (9/28/01) DuPont Corp. Remed. Group., DuPont's Compilation of Historical C-8 Data: DuPont Washington Works Main Plant and Landfills (1/02) -4- 000026  Kennedy, G.L., Draft Report Re: The Occurrence of PFOA in Environmental Dietary and Human Samples (1/02) DuPont, Response to Interrogatory No. 1 of Plaintiffs' First Set of Interrogatories in Leach, et al. v. E.I. duPont de Nemours and Co., et al. (Civil Action No. 01-C-608 Wood Cty. W. Va. Cir. Ct.) (2/18/02) UNDATED Berti, W.R., DuPont Charts Re: Environmental Fate of APFO: Preliminary Studies Modeling APFO in the Ohio River and Adsorption to Soils and Sediments H:\C1assAction\C-8 Environmental Impact-Distribution Studies.wpd 000027 LE 1777 C-8 HUMAN HEALTH RISK EVALUATIONS 1954 1987 1988 1991 DuPont, Memo Re: Handling of C-8 (6/9/54) Smith, H.A., DuPont Memo Re: Request for Acceptable Levels of C-8 in Blood and Community Drinking Water (6/12/87) Graham, R.C., DuPont Haskell Lab Memo Re: AEL Committee Meeting Notes (Discussing AEL and CEG for C-8) (2/15/88) Reinhardt, C.F. and Culpepper, B.W., DuPont Memo Re: Toxicity Review of APFO (2/29/88) Smith, H.A., DuPont Memo Re: APFO (C-8) Hazard Assessment and AEL Review (2/29/88) DuPont Haskell Lab., DuPont AEL/CEG Assessment/Basis for APFO (C-8) (3/8/88) Lanyon, R.D., DuPont Memo Re: Employee Communication - APFO (C-8) Hazard Assessment and AEL Review (3/24/88) Graham, R.C., DuPont Haskell Lab. Memo Re: AEL Committee Notes (Discussing AEL and CEG for C-8) (10/17/88) DuPont, Memo Re: Request for CEG for APFO in Drinking Water (4/1/91) Kennedy, G.L., DuPont Charts Re: C-8 AEL/CEG Calculations (5/7/91) Graham, R.C., DuPont Haskell Lab. Memo Re: AEL Committee Notes (Discussing AEL and CEGs for C-8) (5/8/91) DuPont Haskell Lab., DuPont AEL/CEG Assessment/Basis for APFO (C-8) (5/10/91) Graham, R.C., DuPont Haskell Lab. Memo Re: AEL Committee Notes (Discussing AEL and CEGs for C-8) (6/6/91) Berg, A.S., DuPont Memo Re: DuPont AELs/CEGs (6/11/91) 000028 LE 1778  1992 1993 1994 1996 1997 1998 1999 Graham, R.C., DuPont Memo Re: CEGs for C-8 in Air and Water (10/24/91) Graham, R.C., DuPont Memo Re: CEGs for C-8 in Air and Water (1/22/92) Graham, R.C., DuPont Haskell Lab. Memo Re: AEL Committee Notes (Listing CEG for C-8) (2/7/92) Graham, R.C., DuPont Haskell Lab. Memo Re: AEL Committee Notes (Discussing C-8) (11/4/93) DuPont Haskell Lab., DuPont AEL/CEG Assessment/Basis for APFO (C-8) (12/7/93) Graham, R.C., DuPont Haskell Lab. Memo Re: AEL Committee Notes (Discussing C-8) (12/13/93) DuPont, Acceptable Exposure Limits (AEL) List/Preface (6/17/94) Ramirez, B., DuPont Memo Re: Occupational Health Review - Organofluorine Compounds (11/8/96) Biegel, L.B., DuPont Hazard Characterization for Human Health C-8 Exposure (1/9/97) Trochimowicz, H.J. and Kennedy, G.L., DuPont's Carcinogenic and Developmental Toxicity Hazard Determinations: APFO (10/30/98) Westphal, P., Handwritten Notes/Calculations of URS Greiner Woodward Clyde Re: AELs/CEGs for APFO/C-8 (for DuPont) (4/30/99) Kennedy, G.L., DuPont Draft Memo Re: APFO Acceptable Daily Intake Community (5/25/99) DuPont, Draft Proposal to Conduct A General Human Health and Environmental Effects Risk Analysis On C-8 (6/29/99) 000029 2- LE 1779  2000 2001 Roy, R., 3M Memo Re: Draft Drinking Water Health Advisory (DWHA) - PFOS (7/7/99) Graham, R.C., DuPont Haskell Lab. Memo Re: AEL Committee Notes (Discussing AELs and CEGs for C-8) (12/14/99) Playtis, A., DuPont Memo to All Employees Re: Results of 1999 C-8 Primate Study (12/16/99) Walton, L.A., W.L. Gore & Assoc. Inc. Letter to Maryland Dept, of Env. Re: Request for Approval of Fenceline Screening Level For APFO (3/10/00) Playtis, A.J., DuPont Memo Re: A3 TLV for C-8 (6/9/00) Ramsey, H.D., DuPont Memo Re: PFOA AEL/CEG Calculations (7/7/00) DuPont Haskell Lab., DuPont Acceptable Exposure Limits (AEL) List/Preface (8/21/00) DuPont Haskell Lab., DuPont AEL/CEG Assessment/Basis for APFO (C-8) (8/24/00) Graham, R.C., DuPont Chart Summarizing AEL Committee Actions on APFO (C-8) (9/28/00) USEPA, OPPTS, Revised Hazard Assessment and Biomonitoring Data on PFOS (10/23/00) USEPA, OPPTS, Draft Assessment Of PFOS And Its Salts (12/00) DuPont, Exposure Evaluation for New [C-8] Process at Fayetteville Site (8/20/01) Rurak, D., DuPont Letter to USEPA and WVDEP Responding to 7/24/01 Request for Information on C-8 (8/31/01) Rurak, D., DuPont Letter to USEPA and WVDEP Responding to 7/24/01 Request for Information on C-8 (9/28/01) Eviron Int'l Corp., Draft: A Review of the Toxicology of PFOA (11/01) DuPont, Chart Re: APFO Exposure Guideline Safety Factors (11/7/01) 3- 000030 LE 1780 200? Eviron Int'l Corp., Draft: A Hazard Narrative for PFOA (1/02) Eviron Int'l Corp., Final Report: A Hazard Narrative for PFOA (1/24/02) 3M Medical Dept., 3M Lifetime Drinking Water Health Advisory for PFOA (1/28/02) DuPont, Response to Interrogatory No. 1 of Plaintiffs' First Set of Interrogatories in Leach, et al. v. E.I. duPont de Nemours and Co., et al. (Civil Action No. 01-C-608 Wood Cty. W. Va. Cir. Ct.) (2/18/02) USEPA, OPPTS, Draft Hazard Assessment of PFOA and its Salts (2/20/02) Tetra Tech, Inc., Discussion Points Relating to the Assessment of Health Risk From Exposure to APFO/PFOA (3/7/02) Ullrich, D.A., USEPA (Region 5) Letter Re: Status of PFOA Health Assessment (4/2/02) UNDATED DuPont, Various Pages of Handwritten Notes/Calculations Re: CEG for C-8 in Drinking Water DuPont, Handwritten Notes/Calculations Re: Contribution of Water to Blood Levels (C-8) DuPont, Chart Re: ''Back of the Envelope" Estimation of C-8 Levels in Blood Following 24 HR Exposure at the CEGa. DuPont, Chart Re: "What Are The Issues Associated With Development of Remediation Screening Levels for C-8?" Kennedy, G.L., DuPont Charts Re: APFO (C-8) (Discussing History of C-8 AELs/CEGs) DuPont, Chart Re: APFO Exposure Standards H:\ClassAction\C-8 Human Health Risk Evaluations.wpd -4- 000031 LE 1781 C-8 HUMAN HEALTH/EPIDEMIOLOGY STUDIES 1978 1979 1980 1981 Karrh, B.W., DuPont Memo Re: Medical Examinations for Fluorochemical Workers (7/24/78) Power, Y.L., DuPont Memo Re: Review of Medical Records of Employees With C-8 Exposure (9/20/78) Bower, W.A., DuPont Memo Re: C-8 Exposure Medical Surveillance (9/28/78) Hood, D.B., DuPont Memo Re: APFO (FC-143) Skin Absorption Studies Recommendation For (7/30/79) Fayerweather, W.E., DuPont Memo Re: Status Report on Washington Works Liver Function Survey and Coronary Heart Disease Mortality Study (8/28/79) 3M Company, Analysis of Selected Decatur Employee Serum for Sulfonic and Carboxylic Fluorochemicals (10/4/79) Ubel, F.A., Sorenson, S.D., and Roach, D.E. Health Status of Plant Workers Exposed to Fluorochemicals-A Preliminary Report. 41 Am. Ind. Hyg. Assoc. J. 584-589(1980) Schuman, L.M. and Mandel, J.S., an Epidemiologic Mortality Study of Employees at the Chemolite Plant (for 3M) (2/80) Brewster, V.A., DuPont Memo Re: 6/4/80 Memo Requesting Comments on the Washington Works Communication Draft "Fluorosurfactants in Blood" (6/9/80) Burger, R.J., DuPont Memo Re: Fluorosurfactants in Blood (6/12/80) Fayerweather, W.E., Draft Liver Study of Washington Works Employees Exposed to C-8: Results of Blood Biochemistry Testing (Draft of 6/16/80) Fayerweather, W.E., Liver Study of Washington Works Employees Exposed to C8: Results of Blood Biochemistry Testing (1/15/81) 000032 LE 1782  1982 1983 1989 1990 1991 Fayerweather, W.E., MI and CHD Study at Washington Works Plant ( 11221%1) Karrh, B.W., DuPont Memo Re: APFO (FC-143) C-8 Compounds - Potential Effects on Pregnant Washington Works Females (3/25/81) DuPont, Chart Summarizing C-8 Sampling Results: Washington Works Employees Births and Pregnancies/Status (4/81) Fayerweather, W.E., Liver Study of Washington Works Employees Exposed to C8: Results of Blood Biochemistry Testing (5/31/81) Doughty, J.E., DuPont Memo Re: Washington Works: APFO (C-8) Control Program (2/1/82) Power, Y.L., DuPont Memo Re: C-8 Liver Function Study (with Attached Data) (9/16/82) Loshiavo, J.G., DuPont Memo Re: Estimate of Human C-8 Exposure From Drinking Ohio River Water (10/19/82) Karrh, B.W., DuPont Memo Re: C-8 Exposure at Washington Works (11/23/82) Fayerweather, W.E., Update of 1/28/81 Liver Function Study of Washington Works Employees Exposed to C-8 (Draft #1) (1/7/83) Fayerweather, W.E., Update of 1/28/81 Liver Function Study of Washington Works Employees Exposed to C-8 (Draft #2) (1/28/83) Power, Y.L., Draft Memo Re: C-8 Liver Function Study (with attached Data) (6/6/83) Haugtomt, H. and Haeren, J., Pulmonary Edema and Pericarditis After Inhalation of Teflon Vapor. 5 Tidsskr. Nor. Laegeforen. 584-85 (1989) (English Translation) Smith, H.A., DuPont Memo Re: Review of Washington Works C-8 Data: Personnel Air Monitoring and Blood (4/90) 000033 Fayerweather, W.E., DuPont Memo Re: Cross-Sectional Study of Liver Enzymes Among Washington Works Employees With Potential Exposure to C-8 (10/4/91) - 2 - LE 1781 1992 1993 1996 Kams, M.E. and Fayerweather, W.E., A Case-Control Study of Leukemia at the Washington Works Site (12/31/91) DuPont, Charts Re: Results of Liver Study of Washington Works Employees (1/2/92) Anderson, W.P., DuPont Memo Re: World-Wide Status Review for APFO (C-8) on January 8, 1992 (1/21/92) Gilliland, F.D., Fluorocarbons and Human Health: Studies in an Occupational Cohort (Thesis Submitted to Univ. of Minnesota) (10/92) Gilliland, F.D. and Mandel, J.S., Mortality Among Employees of a Perfluorooctanoic Acid Production Plant. 35. J. Occ. Med. 950-954 (9/93) Power, Y.L., DuPont Memo Re: Review of C-8 [Washington Works Employee Data] and Recommendations (11/3/93) Playtis, A.J., DuPont Memo Re: Work Histories of Specific Cancer Cases (C-8) (11/15/93) Walrath, J., DuPont E-Mail Re: Work Histories of Specific Cancer Cases (C-8) (11/16/93) Playtis, A.J., DuPont Memo Re: Clarification of Job Definitions (For 1981 Liver Study Report) (11/22/93) Playtis, A.J., DuPont Memo Re: Results of the 1995 Study of C-8 Blood Levels (11/3/97) Gilliland, F.D. and Mandel, J.S., Serum PFOA and Hepatic Enzymes. Lipoproteins, and Cholesterol: A Study of Occupationally Exposed Men. 329 Am. J. Indus. Med. 560-68 (1996) Walrath, J. Draft DuPont Epidemiology Surveillance Report: Mortality and Cancer Incidence Surveillance at Washington Works (Draft of 3/5/96) Playtis, A.J., DuPont Memo to All Employees Re: Mortality and Cancer Incidence Surveillance Updates (6/3/96) 000034 -3 - LE 1784  1997 1998 1999 Walrath, J., Final DuPont Epidemiology Surveillance Report: Mortality and Cancer Incidence Surveillance at Washington Works (6/30/96) Power, Y.L., DuPont Memo Re: C-8 Study (Washington Works C-8 Medical Data/Charts) (8/5/96) Zobel, L.R., 3M Letter to DuPont Re: 3M PFOA Medical Surveillance Data (9/9/96) Ramirez, B. and Reinhardt, C.F., DuPont Memo Re: Occupational Health Reviews: Orgonofluorine Compounds (11/8/96) DuPont, Summary of special C-8 Sampling Project (9/16/97) Playtis, A.J., DuPont Memo Re: Results of the 1995 Study of C-8 Blood Levels (11/3/97) Olsen, G.W., Gilliland, F.D., et al., An Epidemiologic Investigation of Reproductive Hormones in Men With Occupational Exposure to PFOA. 40 J.O.E.M. 614-622 (1998) 3M Company, Fluorochemical Exposure Assessment of Decatur Chemical and Film Plant employees (9/3/98) 3M Company, An Epidemiologic Investigation of Plasma Cholecystokinin and Hepatic Function in PFOA Production Workers (9/4/98) Leonard, R.C., DuPont Proposal: Surveillance for Exposure, Biopersistence and Potential Liver Effects from Workplace Exposure to PFOA (3/25/99) DuPont, C-8 Hazard Communication (5/24/99) Reich, C., 3M letter to USEPA Re: TSCA 8(e) Supplemental Notice Re: Serum Blood Data (5/26/99) Dawson, B.J., DuPont E-Mail Re: C-8 Medical Surveillance at Chambers Works, N.J. Plant (6/2/99) Playtis, A.J., Washington Works C-8 Industrial Hygiene Report (6/30/99) 000035 LE 1785 -4-  2000 Olsen, G.W., Burris, J.M., et al., Serum PFOS and Hepatic and Lipid Chemical Chemistry Tests in Fluorochemical Production Employees. 41 J.O.E.M. 799-806 (9/99) Dawson, B.J., DuPont E-Mail Re: C-8 Blood Results for Chambers Works, NJ. Plant (9/22/99) Dawson, BJ., DuPont Memo Re: C-8 Surveillance Results for Chambers Works, N.J. Plant (9/23/99) DuPont, Charts Re: C-8 Medical Surveillance Program For Fluoroproducts (1999) Olsen. G.W.. Burris, J.M., et al.. Plasma Cholecvstokinin and Hepatic Enzymes. Cholesterol and Lipoproteins in AFPO Production Workers. 23 Drug Chem. Tox. 603-620 (2000) DuPont, Internal E-Mails Re: Work Histories for Manufacturing Employees at Chambers Works, N.J. Facility With Positive C-8 Results (2/22/00) DuPont, Internal E-Mails Re: Work Histories for Manufacturing Employees at Chambers Works, N.J. Facility With Positive C-8 Results (2/29/00) Mileti, S.S., DuPont E-Mail Re: Summary of 3M and DuPont Chambers Works C-8 Employee Blood Data (3/21/00) Playtis, A.J., DuPont E-Mail Re: C-8 Blood Testing Results for Washington Works Plant (4/12/00) 3M Company, Determination of Serum Half-Lives of Several Fluorochemicals (6/8/00) Weppner, W.A., 3M Letter to USEPA Re: Use and Exposure Information Profile for PFOA and Salts (6/8/00) Butenhoff, J.M., 3M E-mail to DuPont Re: PFOA Serum Elimination Half-Life Estimate in Humans (6/15/00) Kennedy, G.L., DuPont Letter to USEPA Re: Voluntary Use and Exposure Information Profile for APFO (6/23/00) Zobel, L.R., 3M Letter to USEPA Re: TSCA 8(e) Supplemental Submission: New Data on Half-Life of Perfluorochemicals in Serum (7/13/00) - 5 - LE 1786 2001 Pinchot, R.F., DuPont Charts Re: Washington Works Blood Data Summary (7/14/00) Playtis, A.J., DuPont E-Mail Re: C-8 Pensioner Blood Data (8/8/00) U.S. Dept, of Health/Human Services, Community Health Status Report: Wood County West Virginia (7/00) Dawson, B.J., DuPont E-Mail Re: Results of C-8 Blood Testing at Chambers Works N.J. Facility (10/19/00) Pinchot, R.F., DuPont Charts Re: Washington Works Blood Data Summary (11/17/00) Reich, C., 3M Letter to USEPA Re: TSCA 8(e) Notice for PFOS-Based Production Process Re: Retrospective Cohort Mortality Study of 3M Decatur Plant (12/15/00) Kennedy, G.L., DuPont Letter to USEPA Re: Supplement to DuPont's 6/23/00 Voluntary Use and Exposure Information Profile for APFO (1/25/01) 3M Medical Dept., Descriptive Summary of Serum Fluorochemical Levels Among Employee Participants of the Year 2000 Antwerp Fluorochemical Medical Surveillance Program (3/19/01) 3M Medical Dept., Descriptive Summary of Serum Fluorochemical Levels Among Employee Participants of the Year 2000 Decatur Fluorochemical Medical Surveillance Program (3/19/01) 3M Medical Dept., Descriptive Summary of Serum Fluorochemical Levels Among 236 Building Employees (3/19/01) Jepson, G.W., DuPont Memo Re: Summary of Kinetic Analysis of Plasma Fluoride for APFO, Zonyl 7950, Zonyl FCC and PFOS (3/21/01) Alexander, B.H., Final Report: Mortality Study of Workers Employed at the 3M Decatur Facility (Univ. of Minn. Study for 3M) (4/26/01) Zobel, L.R., 3M Letter to USEPA Re: TSCA 8(e) Supplemental Notice for Sulfonate-Based and Carboxylic-Based Fluorochemicals (Blood Data) (5/15/01) Kennedy, G.L., DuPont Memo Re: APFO Data Discussed With John Whysner (Includes Chart Re: Summary of Hyperplasia/Neoplasia Lesion Incidence in the Liver, Pancreas, and Testes) (5/16/01) - 6 - LE 1787 3M Medical Dept, An Epidemiologic Analysis of Episodes of Care of 3M Decatur Chemical and Film Plant Employees, 1993-1998 (5/15/01) Kennedy, G.L., DuPont Letter to USEPA Re: DuPont's Entire C-8 Blood Data Concentrations Referenced in 1/25/01 Voluntary Use and Exposure Information Profile for APFO (5/24/01) Leonard, R.C., DuPont Memo Re: Epidemiology Surveillance at Washington Works (Summary Data) (6/5/01) Adams, G.L., 3M Letter to USEPA Re: Supplement to 3M's 5/15/01 TSCA 8(e) Notice (6/7/01) 3M Medical Dept., Identification of Fluorochemicals in Sera of Children in the United States (6/25/01) 3M Medical Dept., Identification of Fluorochemicals in Sera of American Red Cross Adult Blood Donors (6/25/01) Rurak, D., DuPont Letter to USEPA and WVDEP Responding to 7/24/01 Request for Information on C-8 (8/31/01) Long, S., "Cancer in Area Above Average" (From 9/9/01 Edition of Parkersburg News') Rurak, D., DuPont Letter to USEPA and WVDEP Responding to 7/24/01 Request for Information on C-8 (9/28/01) Hinderliter, P.M. and Jepson, G.W., Draft: A Simple, Conservative Compartmental Model to Relate APFO Exposure to Estimates of PFO Blood Levels in Humans (Draft Dated 10/10/01) 3M Medical Dept., A Longitudinal Analysis of Serum PFOS and PFOA Levels in Relation to Lipid and Hepatic Clinical Chemistry Test Results From Male Employee Participants of the 1994/95, 1997 and 2000 Fluorochemical Medical Surveillance Program (10/11/01) 3M Medical Dept., A Cross-Sectional Analysis of Serum PFOS and PFOA in Relation to Clinical Chemistry, Thyroid Hormone, Hematology and Urinalysis Results From Male and Female Employee Participants of the 2000 Antwerp and Decatur Fluorochemical Medical Surveillance Program (10/11/01) 000038 - 7 - LE 1788 2002 DuPont, Response to Interrogatory No. 1 of Plaintiffs' First Set of Interrogatories in Leach, et al. v. E.I. duPont de Nemours and Co., et al. (Civil Action No. 01-C-608 Wood Cty. W. Va. Cir. Ct.) (2/18/02) UNDATED DuPont, DuPont Memo Re: Overview of Epidemiology Studies on PFOA Done at DuPont (undated - post 1996) DuPont, DuPont Memo Re: C-8 in Blood Monitoring Results in FLPR Dordrecht Facility (undated - post 2000) H:\ClassAction\C-8 Human Health-Epidemiology Studies.wpd 000039 - 8 - LE 1789