Document yrJQDdD2ODeo3Jq6X70DjmE46

July 20, 1970 Mv. J.J. ?iedlad<) w.ii.i' Cho.aiic.-; L Co. <,y.v:.ic.hockcn, a unnuylvonia 19*123 i lv ! V.-/ v_. C:v-' R. frail k'AJ t '.t we send you the acute toxloli; acroe-iin,-? and o-''s.n' data that we have on Aroclor 54b0, 1221 and 1 Those u'\i:a are a a follows; 4. flvoclo?.* 5460 Ac.:to oral ID.-.q - Rat - 33-3^* oclution in com oil - 19,200 rac/Us. '* olaaecu ea practically non-toxic. ti.v.il.1 L Tethal Uoso - Rabbit - Intact Clipped Sicin - 333tf solution in cJrrToTT ->7940 mg/kg. Classed aa practically non-toxic. 20 Day Drrr.v.'.l - Rabbit - Daily application - ICO 103/103 - no adverse effect - 250 rag/kg - LD50 21 Day ChicleThem - Doses of 50# 200, or 400 ppn - no adverse effects yo Day Oubacut,: - Rata - 100 ppn regarded ao no effect level - jXjij ppn questionable effect - no effect level - 1000 ppm questionable effect - no effect level Chicken Toxicity Study - Docea of 500, 1CC0 ard 20C0 ppm. At 500 ppm level 03,'; production and egg weight ccrr.-carablo to control but hatehabllity was lower than controls, rlatchability severely depressed at higher dc.e levels. Tnere were no groaa pathologic findings. Aroclor 1221 Acute oral LDgq - Rat - Undiluted - 3980 Eg/kg. Claased aa slightly toxic. Acute Minimal Lethal dose - Rabbit Skin Intaot Clipped - >2000-0160 ag/kg. Classed aa slightly toxic. 20 Day Dermal - Rabbit - 12.5 com oil solution - Daily application " lvooe levelo' 150, 250, and 500 rag/kg/day 150 mg/kg - no adverse effect OSW 020328 STLCOPCB4008257 -2- 250 mg/kg - LD50 ;.ro al. :n.U`.Lcant grooo or microscopic pathologic tissue alterations noted among surviving test animals which were sacrificed. . j.li . iw*r* I Acr.ro o-;U - Rato - Undiluted - 11,900 mg/kg. Classed praotlcally ' non-toxic Apv 5linir.-il. Rabbits - intact Skin - Undiluted 2<:Cj m-i/kg. Olasucd mildly toxic. al - V'vblt - 'f;* corn oil solution - Daily application Dbcie"X:voio 10, 50, 100, and 200 mg/kg, 10 ifi'/Vg - no adverse ofDec to 50 and 100 mc/kg - liver diccoloratlcn mcroacopically Microscopic examination rovoalcd raodei'atc hepatic necrosis All other tiaauea comparable to tho controls, 200 mg/kg - anlmalo succumbod before any significant local skin reactions. Local akin reactions, i.e. scaling, wrinkling, and fisouring soon in all animals receiving 10, 50, and 100 mg/lcg, I trust this is the Information that you seek. Sincerely, WHH/ebv cc; W. Clark R. Brell - Wilmington William H. Hunt, Ph.D. Toxicologist Medical Department DSW 020329 STLCOPCB4008258