Document xe8Gzg6yM348vKp01XaGeN6

V M'jUr-13-1992 0S ' 03 FROM CMA TO 914124342137 P.Ol CHEMICAL MANUFACTURERS ASSOCIATION CHEMSTAR FAX NOV I 9 1992 To: Ethylene Dichloride Panel Members Jim Barter Thomas Grumbles William Hayes W.C. Holbrook Phillip Ostrowski Thomas Robinson PPG Industries Vista Chemical Dow Chemical BFGoodrieh Occidental Vulcan Chemicals 412-434-2137 713-588-3456 517-636-9899 216-447-6459 716-278-7297 205-877-3102 Date: November 18, 1592 # of pages (including cover) If there are any problems with this transmission, please call 202-887-1146. Re: Epidemiology Study from Union Carbide This telefax is in regards to the epidemiology study conducted by Union Carbide, entitled ''Mortality Due to Pancreatic and Lymphopoietic Cancers in Chlorohydrin Production Workers". A draft copy of the study report was sent to the Panel on October 5, 1992. You may recall that the report implicated ethylene dichloride as causing pancreatic cancer in the workers. Tom Robinson has suggested that the Panel communicate with Union Carbide regarding this conclusion, specifically that dichloryl ethyl ether, a co-product identified in the study, may be responsible for the cancer finding. Tom notes the following items for consideration: the inhalation study with ethylene dichloride conducted by Maltoni did not show carcinogenicity; pancreatic cancer has not been identified in other EDC studies; a compound of similar structure, dichloryl methyl ether, is a known human carcinogen; and dichloryl ethyl ether has been classified as a genotoxic compound. If the Panel is interested in responding to Union Carbide's report with the above arguments, please let me know. Jane Teta, one of the study authors, has already submitted the manuscript for consideration in a journal. If the manuscript is published, we may want to investigate submitting a formal response to the report. In addition, because there have been TSCA 8(e) and 8(d) letters submitted on this report's findings, communications with EPA may also be in order. 2501 M Street, NW, Washington, DC 20007 202-887-1100 Panafax 202-837-1237 Telex 3961 7 'CMA W$H) SL 063816 V NC'vl'*19-1992 09:03 FROM CMP TO 91412434213' P.02 Please let we know how you would like to respond to this issue. Although there is no specific deadline, I would think it would be helpful to address this issue quickly. Thank you for your consideration of this matter. Please call me at 202-887-1146 to if you have any questions or comments. Regards, Kathleen M. Robef"ts Manager Ethvlene Dichloride Panel SL 638l7 TQThL P.U2