Document xJ9vD71ONE1mDd9q4qLzvEqG
AR226-2746 -
' Copies to:
E. I. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine
HASKELL LABORATORY REPORT NO. 128-68
Material Tested: Ammonium Perfluorooctanoate
Material Submitted
Plastics Department Fluorocarbons Division
Haskell No.: 5489 O m e r Code
ACUTE ORAL TEST
ChR-CDUmaie ~ L t-St
38 a* aq?eou solution (pH~6), was administered by intragastric intubation to young adult
LhR CD male rats in single doses. Survivor were sacrificed 14 days later.
76
Results:
Solution %
15 15 10
3 3 2
12
1.5 1 1 1 0.5 0.05 0.05 0.05 0.05 0.01
Dose rcg/kg
2250 670 450 300
200
170 130 120
90 77 60 40 26
5.1 3.4 2.3 1.5 1.0
Mortality*
D 1 d. D 2 d.
S 14 d.
S 14 d.
S 14 d.
S 14 d.
S 14 d.
S 14 d. s 14 d. s 14 d. s 14 d. s 14 d. s 14 d. s 14 d. s 14 d. s 14 d . s 14 d. s 14 d.
Toxic Siens Lethal Doses: uncomfortable, chewing motions, polyuria, increased respiration rate and face-pawing on day of dosing; at 2250 mg/kg shovel nosing, and at 670 mg/kg slight salivation after dosing
Nonlethal Doses: at 90 mg/kg and above, feces small and irregularlyshaped for 1-6 days after dosing; at 90 mg/kg and above, uncomfortable after dosing for 1-5 days; slight initial weight losses at 26 mg/kg and above for 1-2 days
Controls
feiKht When Killed isl
Bodv
Liver
275 310 313 362 349 347 319 352 317 403 380 346 374 350 329 354
52-377
17.85 16.30 17.50 25.10 19.25 24.62 16.00 24.78 16.15 21.70 19.00 17.40 18.54 15.60 15.89 17.48
15.09-18.39
L.W./B.W. X 100
6.49 5.26 5.59 6.93 5.52 7.10 5.02 7.04 5.09 5.38 5.00 5.03 4.96 4.46 4.83 4.94
4.29-5.11
ALD 670 mg/kg
) days after dosing.
Company Sanitized. Does not contain TSCA c a t
lumma^: Ammonium perfluorooctanoate is slightly toxic for the male rat when administered orallv its Annrnv^.fo r n
Dose (ALD) being 670 mg/kg o body welgnt. This compound appears to cense liver e n U r g e M n t in r s
^7 s
es low 60-90 mg/kg. Besed on cUnicel signs, It also soil ss s g a s t r o L t e i i L S " S " .
g U d Se"
SBF/jch Date: June 13. 1963
Report by: Approved by:
/? Susan B. Oral Toxicology Section
Company Sanitized. Doe?, noi contain TSC CBE
