Document x5K23QqOxwkqpqO47o097G0rb

AR226-2826 H askell U b a M ryJ " oorrTioxiLcoolo?gyr "andT ?Indu"stpr* i" airl Mejdicine HASKELL LABORATORY REPORT NO. 129-66 ACUTE ORAL t r ? - Resulta ; Suspension ____ % Dose g/kq 40 17.000 40 11.000 40 7,500 30 5,000 30 3,400 10 2,250 10 670 Mortality 0/1 0/1 0/1 0/1 0/1 0/1 0/1 " - ` : \ r i a " Z r S r c pi ".ou by * * * 1 - * y,,u,E o >ss. .a' ta22225500"m^g/kg8i ^anddi a* biovj e' ,` 8,it * *-*'or* rapid respiration, face-pawing, diarrhea for 4-5 days, wet perineal area, prostration at two highest levels on day of dosing ulSbgloeic Chanson* ALP tc,c " " eriai' > i7i0 e /k vlot contau* `S C A G S l Soaoed-Doe* Kiy' Results (Cont'd n); Suspension Dose 40 17,000 40 11,000 40 7,500 30 5,000 30 3,400 10 2,250 10 670 -2 Mortality Pathologic Changes* 0/1 Nonlethal PoseB: pallor, 0/1 None attributable to test 0/1 oocn8Ulir respiration,, diarrhea at Z250 mg/kg and above, wet material, 14 days after dosing 0/1 0/1 perineal area at 7500 mg/kg 0/1 , X Ve',initlal weight loss 0/1 at 2250 mg/kg and above, for 6 days at 17,000 mg/kg 40 17,000 1/1 40 11,000 1/1 40 7,500 0/1 n i ! rea', chewing motions at 30 "8'k8 prostration at 5,000 0/1 17,000 mg/kg, death day after 30 dosing 3,400 0/1 10 2,250 0/1 Nonlethal Doses: pallor, 10 irregular respiration, diarrhea, 670 0/1 initial weight Iose at ail levels -- for three days at 7,500 mg/kg 8 ALP > 17,000 mg/kg 11,000 mg/kg * Tissues examined and duodenum. included lung, trachea, liver, kidney, spleen, thymus, bone marrow, testis, brain, esophagus, stomach Company Sanitized. Does not contain T S C A CB1 Summary: The three M no ,b n o r a ,i u i " tbat - * HS:clm Date: August 15, loan 3- Report by: _______ ^ t ^ w - V tokn Chief, 5 3 p Toxicity Section Approved by: Company Sanitized. Does not contain T S C A C B I