Document wqvZYZ4Qzr5O3MMz3E5dj9XB4

AR226-2519 Ta-Wei Fu /I 11/12/02 02:13 PM To: Charles J Noelke/AE/DuPont@DuPont cc: Steven H Swearingen/AE/DuPont@DuPont Subject: Eureka! Charlie, Steve has been working on two samples from Fayetteville in the past few days. He just called me a few minutes ago to report on this initial finding in the attached note. He is quite excited about it. He will check with Ron for NMR results on these two samples for reference. Ta-Wei -- Forw arded by Ta-W el Fu/SE/DuPont on 11/12/2002 05:08 PM Stephen R Peck 11/12/2002 05:08 PM To: Ronald V Crosmun/CL/DuPont@DuPont co: John E Crum/SE/DuPont@DuPont, Ta-Wei Fu/SE/DuPont@DuPont, Leo M Lech/DuPont@DuPont, Thomas W Mahlberg/SE/DuPont@DuPont, Mark E Reeder/SE/DuPont@DuPont Subject: Eureka! Ron, A s we discussed, treatment of the acidic waste sample for the A P F O determination by G C test gave a pink-violet hexane extract consistent with iodine. After discussing the observation with Leo Lech, the colored impurity is most likely I,". (Thanks, Leol) The good news is the color is pH dependent. Neutralization of the sample with NaOH removed the color. The better news is that the neutralized species can be analyzed by HPLC. No A P F O was found. The (current) best news is that H PLC analysis of the neutralized sample spiked with A P F O was able to detect the A P FO . Separation from the early-eluting (ionic) species was excellent. Pathforward is to prepare some APFO-spiked acid to use as standards, then determine best neutralization procedure. Bottom line: a usable method appears imminent. Regards, Steve EID 6 9 1 4 1 2