Document wgZvQkqBpJL9BdaaOz9v86wVD

6 000708 CHAMBERS WORKS FLUORQCHEMICALS IN BLOOD STUDY (1) Results of study - levels of fluorine in the blood of Chambers Works employees, (Inorganic and low volatility ORGANIC FLUORINE) (23 Industrial Hygiene Survey Manufacture of Manufacture of R, D, Richardson/amb 18 May 1979 Sanitized. Does not contain T S C A CB I 1V 000709 ORGANIC FLUORINE IN BLOOD Group (sample size) 311 Data General population (106) Punt office worker Plant worker - general Plant worker - long service in f/c area NEWER PUNT OLDER PLANT ppm Organic Fluorine* 0`002 to 0,13 [0,023** 0,01 to 0,06 0,13 to 1.18 0.9 to 9,1 5,9 to 71 Du Pont Data Wilmington control group (25) Chambers Works group (55) (23 of 25) 0 - 0,38 *** [0.094] (54.of 55) 0 - 0,37 **** ' CO.153 Conclusions Chambers Works employees do not have elevated levels of organic FLUORINE IN THEIR BLOOD AS WAS REPORTED FOR 3m WORKERS, The mean value for Chambers Works employees was slightly higher THAN THE WILMINGTON CONTROL GROUP CO.15 VERSUS D,'0943j BUT ALL VALUES ARE CONSIDERED TO BE "NORMAL* (<1 PPM) EXCEPT ONE VALUE in the Wilmington control group (10,6 ppm), * By difference between TOTAL AND INORGANIC FLUORINE ** [Hedan values] except 2 values 10,6j 0,78 EXCEPT 1 VALUE 0,'89 ppm I 000710 CHAMBERS WORKS FLUOROCHEMICALS COHORT Chambers Works employees were identified who Cl) HAVE HAD JOB ASSIGNMENTS WITH POTENTIAL FOR EXPOSURE (2) ARE STILL ACTIVE OR ARE READILY AVAILABLE ON SITE Blood samplesi taken at regularly scheduled physical examination Job Assignment Location Number Number Checked Identified To Date' (%) R&D Jackson Lab, Technical Lab. 50 18 (36) Development Spec. Chem, Manufacturing West 36 6 (17) Manufacturing Spec, Chem, East 84 26 (31) Other 29 5 (17) 199 55 (28) @ Informal check with supervision indicated that group (55) sampled was representative of cohort (199), F oooy^x CONCLUSIONS - INDUSTRIAL HYGIENE SURVEY A) 1) Environmental monitoring data suggested conditions in the MANUFACTURING FACILITIES TO BE NORMALLY <5 MG/m ^ ^ P ^ (8 HRs,), However, excursions to raise this level to 30 TO 40 MG/m3 HRS.) HAVE BEEN OBSERVED ON MULTIPLE OCCASIONS, 2) Additional environmental monitoring required to identify EXPOSURE SOURCES AND DEFINE POTENTIAL EXPOSURE LEVELS. (In Progress) 3) Most probable exposure sources are drumming anb-bebrummng FACILITIES, AND TO A LESSER EXTENT SAMPLING EQUIPMENT AND PROCEDURES. 4) Drumming, be&rummtng and sampling facilities are of a low STANDARD FOR CONTAINMENT BY ENGINEERING CONTROLS, (NOT ENCLOSED, NO LOCAL VENTILATION) 5) A CONTRIBUTING FACTOR IS THAT THE FACILITIES ARE ENCLOSED IN A BUILDING, PROMPT ELIMINATION OF PROCESS LEAKS AND - MAINTAINENCE OF VENTILATION IS ESSENTIAL,1 TO BE Company Sanitized. Poes no* contain T S C A CB I RECOMMENDATIONS 1) Discontinue program to determine fluorine in blood','. 2) Advise employees that blood analysis program has been dis continued due to uniformly favorable results. 3) Upgrade'facilities, if required, to meet haskell laboratory EXPOSURE LIMIT GUIDELINES WHEN THESE ISSUE. 18 May 1979 ooo?ta