Document vVwdpED3wMjJJKzrrZmM9rEDR
Author John W. Server
study Completed On
May 2, 1990
performing Laboratory E. I. du Pont de Nemours Haskell Laboratory for Toxicology ndjitfustrial Medicine
P. 0. Box $0, llktort Road Newark, Delaware 19714
iiboratory Project ID Haskell laboratory Report No. 180-90
Page 1 of 6 r :mpany Sanitized. Does not contain TSCA CBF
Du Pont HLR 180-90
GENERAL INFORMATION
Material Tested;
,
Medical Research No.:
Haskell No.: Haskell Test Code:
Physical Form:
Purity; Composition;
18,267 \Amber dispersion
Synonym; Stability;
Sponsor;
SeThe test materia1 was assumed to be stable
Ser
conditions of administration.
Chemicals and Pigments 0ePaJtJ" *
rc
E. I. du Pont de Nemours and Company, I.c.
Wilmington, Delaware
Material Submitted By;
i B c a i H r T p i g m e n t s Department E. I. du Pont de Nemours and Company, me.
Jackson Laboratory Deepwater, New Jersey
Study initiated - Completed;
2/16/90 - 5/2/90
In-Life Phase Initiated - Completed;
3/6/90 - 3/20/90
Notebook;
There are 6 pages 1n this report
Distribution:
2-
Company Sanitized. Does not contain T SC A CBt m
^ i3
Si|l*ih.' '::ii--it .-f;
ai:H-*i
__________________ was t C ' lew Zealand unite raopitsi^ndjfls
Intact skin of 2 ale
furs Under the >31)00 og/kg of body welgnt.
;ond1t1ons of this test, the
pmately 24 hours after
Ibservatlons for
after for 14 days. This
ippllcation of the test water*laatteerrllail is consiodered two h w e veriy 000 ma/kg) when applied to the dipped
m w m j 4W-D greater than iatadt skin of male rabbits.
Work by
HaTm
Technician
i
J
Study Director
John M. iarver
Technologist
Approved by:
Dolores -E rtalek, Ph.fi. Research Toxicologist
Acute and Developmental Toxicology Division
7^Reviewed and
Approved for Issue
iJ
r/<y3a
Study Director
Acknowledgments:
. pirticiiJtedffinn
TTIt<ehhrIeeesccaoSnnddBuiucschtteelo.f
and Maureen this study.
Godwin
also
jWS:a1r:HLR41.8
3Company Sanitized. Does not contain T SC A CB1
..
H-ilr 1^ 0 :?it;:'
'y47-'./T
Pont RIA 180-90
STUDY: H# 18,267
Approximate Skin Absorption 0
in Rabbits
AUDITS:
Items Audited In-life Observations STSPS, Records and Pinal Report
Audit Dates 3/7/90
4/12,16/90
SHORT-TERM AUDIT REPORT MlJMBER:_ DATE FINDINGS REPORTED TO m a n a g e m e n t a n d
Reported by:
. Haoill lity Assurance Auditor
DIRECTOR: 4/16/90
to
te
-4Company Sanitized. Does noi corftainTSC CB1
Du Pont HUI 180-90 -
..--
, X..
, *',, pproxlmate lethal dose
The purpose of this1t|jpltfMl- *"
defined as the lowest dose
(ALD) by skin absorotM i^U
path of a test animal
of the test material adm1tnsl
pd according to the
w a w *applfcable^EPA Goodj
at-
i. Areas of noncompllance existed that
mmtetLS AMD METHODS
A. Animal Husbandry
Young adult male New
Hare Marland, Hewitt, New
suspended, stainless steel
unique identification numb
cage. Purina Certified Rr1
libitum. Rabbits were qu^
chteoianmldeirf-tTcifoonontrsroaolpflpetrdho,exim1ra2ot-oehmlosyurwj2i. >U1regtlia.tr/gizVe-tfecoduefrxacdruer*srit^teendyspeoe'or-atstuidEne"!<*'otC"hfe52,sn!e0!efdCr?.aJn?g2e4(cs;^aarnnelai
relative of small
mhaugmindiittuydeofand5/0o%r."brief
duration
and
did
not
adversely
validity of the study
I j i
t
B. Protocol
closOenlythcelipdapyedptroiorexptooses;,iaihdityuhianfritkttitafetrdioowmni,tthhteih>esicah*patui1lrcaocrofltl"oa^rth,ertlouSmporJaerrvwe,nSt
region. The Ingestion of
rthaebbittesstwemraetrial
or
disruption
Of
the
wrappings.
SThe test material was
The rabbits were dosed at test material was spreadj animal. The rabbits' body
i
day of dosing.
M ! After application of
4reff.^j* ')
wsaeudrhceecseaispvsepilviebeandldaatygoeer.stheofAftrtpieearatsI"tiacpfpiinl"m:
stretch gauze bandage and the rabbits were returned
elasc* to the.r
cages.
5-
j
Company Sanitized. Does noi coniata T S C C B l
Du Pont HLR 180-90
Approximately 24 hOMf*
rabbits were removed from
Excess test material w*s w
and the skin dried with/ , observed for clinical sign* of toxic/
t <iv 24 hours after
Oabpspelrivcaattiioonnsanfodrtchleinnidcaallly*b!rttt*r"forl
S' y
S
S .U
(" l1"11" " " " " iL 9hout the study. The
Observations animals were
for mortalities weighed on day
1,
7
and
14
following
treatment.
C. Records Retention
All raw data and the f
Haskell Laboratory for Tox.
esasBasrsy*de Nemours
Management
aCenndteCro.mpaWn1yl,m1Nnegvtion,
Delaware.
RESULTS
A. Dosage and Mortality
S-TWO rabbits w e r e
Dosage (mg/kg)
5000
5000
" - V S S . 1 et,1?ed below.
Dos (mLl
13.2
13.2
Initial Body Weight (g)
2884
2897
Mortality No No
B. runica! Signs
HO clinical signs of toxicity ere observed during the study.
CONCLUSION
Under the conditions of this study,.h?sAc S n s d i S ^ ? h a v e very low
}e S f t
the clipped, intac,
n of male rabbits.
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Company Sanitized. Does not contain T S C A C B I
