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M - 37,0 C; -- WASHINGTON WORKS C-8 INDUSTRIAL HYGIENE A. J. Playtis, 6/30/99 CONTAINS NO CBI 434 EIDS10279 P-2 C-B IN BLOCK) - HISTORICAL 1978 Informed by 3M that C-B i* found in the blood of exposed worker and persists for a long time. 1970 C-8 found in blood of DuPont workers. 1980 Worker* with blood C-B found to have n o m a l liver function. 1981 Birth defects scare - additional saapling. 1932 1930 Blood program continues on voluntary basis - no trends noted. II Fonsol review of blood data. V.- \.- f \t 1993 Journal Of Occupational Medicine study of 3M worker*. 1993 1995 No connection found between MW canoer cates end C-B exposure. First 5-year "snapshot*. f 1996 No excess disease incidence found in 51 WH employees with highest C-8 blood levels. 1 1996-7 Follow-up fro 1996 blood study. ! i -z> v '* ~ t : " `J . 4 ... f-' 3S EXD510280 prmnn977ifl P-3 C-8 DOCUMENT H S T Liver Function Study Of Washington Works Employees Exposed To C-8. H. E. Fayerweather, 1/28/81 Review OT Washington Works C-8 Data. Personal Air Monitoring And Blood Data. H. A. Smith, 3/19/90 Work Histories Of Specific Cancer Cases. A. J- Playtis, 11/15/83 SuMsary Of 1995 C-8 Blood Tasting. A. J. Playtis, 5/7/96 C-8 Study. Y. L. Power, 8/5/96 Washington Works Response to Ranirez/Reinhardt O.H. Review. A. J. Playtis, 12/12/98 C-8 Industrial Hygiene Follow-Up. A. J. Playtis, 12/18/96 Sumaary Of 8pecial C-8 Sampling Project. J. Nichols, 9/16/97 EID510281 rvwiA'vy*7d a P-4 1990 C-8 INDUSTRIAL HY6IENE DATA REVIEW (HA Smith, J6 Loschi avo, RD Lanyon, HE Crawley) CONCLUSIONS (Recognizing the data limitations) There 1s a correlation between blood and air C-8 levels that 1s confused by dermal exposure. Exposure at the AEL of 0.56 mpb would result in a blood level of about 3 ppm. Background blood level for the Teflon* area is between 0.1 and 0.5 ppm. Dermal exposure Is the cause for higher blood levels. Half life for C-8 in blood is about 4 to 5 years. Annual blood testing is not useful and should be replaced by snapshots" at longer intervals. EID5102B2 DnnnmvTon P-5 1995 C-8 IN BLOOD "SNAPSHOT* PURPOSES Monitor the overall effectiveness of our C-B Industrial hygiene prograns. Create and maintain a continuous data base for epidemiologic surveillance of our exposed population. Provide closure for issues raised by the 1990 data review. Honor employee requests for voluntary testing. TEST POPULATIONS Employees in C-8 jobs (82 of 140) Employees not in C-8 jobs with a previous result >3 ppm (9 of 12) Pensioners with a high previous result (9 of 19) Volunteers (18) EIDS10283 DrVWV>7771 p.6 1995 C-S BLOOD STUDY CONCLUSIONS o AVERAGE BLOOD LEVELS FOR DIFFERENT JOBS RANGE FROM 0.5 TO 3.5 PPM o MOST JOB AVERAGE BLOOD LEVELS HAVE GONE DOWN FROM 1989 TO 1985, PROBABLY DUE TO REDUCED SKIN CONTACT o NO ONE TESTED HAD A BLOOD LEVEL >5 PPM o TWO PEOPLE IN THE SAME JOB FOR MANY YEARS CAM HAVE VERY DIFFERENT BLOOD LEVELS 0 MECHANICS AVERAGE ABOUT 1 PPM o PENSIONER DATA INDICATES A BLOOD HALF-LIFE OF ROUGHLY 4 YEARS, BUT WITH HIDE INDIVIDUAL VARIATION. o THE CORRELATION BETWEEN AIR LEVELS AND BLOOD LEVELS IS WEAK O BETTER DATA COULD CHANGE MANY OF THESE CONCLUSIONS 3^ EID510284 PrwW977C>0 P-7 TABLE 1 RESULTS SUMMARY - OPERATORS JOB 08PE 08PF 08PH oapi OBPJ 08PK 18PA 18PB 16PC 18P0 18PJ 18PK DESCRIPTION autoclave polykettle dispersion FP finishing FP packout C-B dryer recovery FEP polykettle FEP extruder/oven FEP wet finishing FEP packout PFA/FEP bead FEP safety/disp 1995 AVERAGE (nl 2.S (6) 2-9 (7) 2.2 (2) 2.2 (5) 0.6 (5) 1.7 (2) 2.3 (A) 1.6 (5) 3.3 (2) 0.1 (3) 0.7 (2) 2.1 (2) 1989 AVERAGE (n) 4.7 (7) 4.0 (4) 3.2 (3) 2.0 (6) V. 0.5 (3) RESULTS SUMMARY - MECHANICS 58MC S8M0 58MS 68MA 68NB FP/disp/gran/TA general shift process Ell general shift FEP Eli 1.4 (1) 1.1 (8) 0.8 (7) 1.1 (5) 0.9 (7) EID510285 W Q ______________________ P000077793 p.8 HALF LIFE RESULTS FROM PENSIONERS C8 DATE PPM 4/89 5.7 3/87 1.2 9/81 6.5 3/88 2.8 8/84 2.4 7/84 5.9 3/85 3.0 9/82 6.3 3/88 1.7 RET. DATE 4/91 6/92 4/85 12/92 4/85 12/81 4/B5 12/82 12/93 C8 DATE PPM 3/95 4.3 3/95 1.1 3/95 1.1 3/95 2.2 3/95 .72 3/95 .94 3/95 .14 3/95 .57 3/95 2.4 1/2 LIF (YEARS) 9.7 22 3.9 6.5 5.7* 4.0* 2.3* 3.5* -- For * results, n- 4 average 3.9 sigma - 1.4 using log n * --.301 t no ti/2 Wl E 10510286 DAnnm77n a P-9 WASHINGTON WORKS AIR SAffUMG RESULTS <10% AEL <50% AEL <100% AEL >100% AEL TOTAL 1994 40 14 3 0 57 PERSONAL SAMPLES 1995 1996 1997 15 48 60 14 19 31 1 2 10 001 30 69 102 1998 50 18 9 D 77 1999 30 11 1 0 42 1994 43 AREA SAMPLES 199S 1996 26 29 1997 171 1996 4 1999* 18 through 5/31 o PERS (DOHKS) aystcM usid to determine idiere personal saaplas rs needed. o S12T used to detenaine sapling frequencies, usually 90, 180, or 360 days. o Area samples have support role, identifying looations where C-8 levels are high. WA E ID510287 p n n n ro n o z I PATH FORWARD Finish Data Analysis Employee Conmmlcatlon Site Industrial Hygiene Efforts Toxicology Work (Do we need a BEI?) Continue Annual Voluntary Testing Take Another Snapshot In 2000 CON IAINS NO CBI EID510288 Pm m ?7T >R WASHINGTON WORKS C-8 INDUSTRIAL HYGIENE - LOOKING FORWARD ONGOING SITE PROGRAMS o AIR MONITORING o BLOCK) MONITORING o EPIOEMIOLOGY o CONTINUOUS IMPROVEMENT OF CONTROL ASURES QUESTIONS TO BE ANSWERED O D O N E HAVE SUFFICIENT TOXICOLOGY DATA? o SHOULD WE DO ADDITIONAL MEOICAL SURVEILLANCE? o DO HE NEED A BEI? o ARE ME SATISFIED WITH OUR CURRENT AEL? o SHOULD BLOOO TESTING BE MANDATORY? EID5102BS p m n n ?7777