Document rpwx03oyw21V74Nk8ZOVBE4LJ

AR226-1402 W a a 6 l/f-OJl i CENTRAL RESEARCH AND DEVELOPMENT DEPARTMENT . HASKELL LABORATORY FOR TOXICOLOGY cc: 0. 3. Armitage- ANO INDUSTRIAL MEDICINE P?D, M-5622 >Vl _ W. L. Sprout *V 1^ TO : FROM: 0W}/ Ju-.S 25, 1987 At- H. A. SMITH vj - / a ./V PPD M-5625 G. L. KENNEDY, 3R.._. vf>' !^ A /1 0 /'-' r (ReATMTM:ONI UM PCR Letter F LUOROOCTANOATC HAS-GLK, 6/12/87 3A An acceptable level For ammonium p e r f l u o r o o c r a n o a t e (C-8) in the blood of workers would be 0.5 p p m . This v a l . s nas been calculated using the average daily C-8 accumulation rate observed in new employees who were exposed to airborne c o n c e n t r a t i o n s of 0.008 mg/nr (memo, 0. G. Loschiavo to R. 3. Zipfel, 7.'29/82). From this data, a steady-state concentration of 0.5^5 opm, which represents the dynamics of exposure and elimination, was estimated (Memo, T. P. Pastoor to 0. G. Loschiavo, ' 2 5 / 8 2 ) . These estimates appear consistent with most of the r e s o r t e d human data but the data base is not too extensive. In a d d i t i o n , in rat inhalation experiments, no s^gns of toxicity were d e f e c t e d following exposure to 1 mg/nr , an atmospheric c o n c e r : r a t i o n corresponding to a blood level in the male rat of 12 oon. Extrapolation of the data relating the concentration cf C-8 in the air to blood levels in the rat "suggests that i n r s l a t i o n of 0.01 mg/nr would result in blood level of approx i m a t e l y 1 ppm (equation is blood level = 12 "Vair concentration). An acceptable level for community drinking w a t e r , wo u l d be 5 p p b . Thia value has been arrived at as follows: - 1. The-AEL (8-hr TWA) is 0.01 mg/m^; a worker b r e a t h i n g 10m /day would take in 0.1 mg. Assume 1QCS a b s o r p t i o n . .2 Daily ingestion by man of 2 L of water/day: 0.1 rag/2L (assume 1003 absorption) s 50 ppb (a c o n c e n t r a t i o n in water) . A\ . O A.;v. 000200 s HID078779 3. However, community populations are not equivalent to worker populations. Therefore, factor in a 10X reduction - 5 ppb (concentration in water). This doesn't take into account the time factor (worker exposed 8 hours, not-exposed 16 hours, etc. whereas drinking water intake could be anytime during 16 hours, off 8 hours, etc.). However, the long half-life of this chemical in the blood might make this consideration less important. I hope that these suggested guidelines will be useful. Please call if you have any questions. GLK:ms * 000201 EID078780 WJt'SOOZfH