Document reMkbqe0qE1zm7K9ZZdKG2E4r
AR226-2831
Copies to:
Han, r vE ' 1 ` du Pnt de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine HASKELL LABORATORY REPORT NO. 246-71
Procedure : The test material
~ : u " cs *' sln8le du
Results:
ACUTE ORAL TEST
Suspens ion r/o)
25 25 25 25 25 12 12
<m g/fcg>
17,000t 11,000t
7,500t 5,000 3,400 2,250
670
Mortality*
S - 14 d. S - 14 d. S - 14 d. S - 14 d. S - 14 d. S - 14 d. S - 14 d.
L iverWeight When Killed (p.)
332 17.50 321 17.85 347 19.00 346 17.40 346 17.38 320 15.20 349 17.00
s < ) d. - Sacrificed ( ) days after dosing t Administered in divided doses
L.W./B.W. X 100
5.3 5.6 5.5 5.0 5.0 4.8 4.9
Clinical Signs Jone
ALD 17,000 mg/kg
Company Sanitized. Does not contain TSCA Cl
TEN-DOSE ORAL SUBACUTE TEST
Procedure: The test material was administered by intragastric intubation, as a 15% aqueous suspension, to six young adult ChR-CD male rats,
and were intubated with corn oil. S r e e t / T \ fr tWO WeekS; in addition' ^ rats served as controls
after the last dose.
Three test and three control rats were sacrificed four hours and 14 days
Results:
Dose
2200
0 (Control)
Mortality 0/6
0/6
Weight of Liver (g)
Animals Killed;
After
14 Days
10th
After
Pose
10th Dose
22.2 23.5 25.2
12.5 ' 14.8
14.2
20.6 17.6 21.6
13.5 14.7 19.8
L/W./B.W. X 100
Animals Killed:
After 14 Days
10 th
After
Dose 10th Dose
7.4 5.2 7.7 4.6 8.4 5
4.1 3.5 4.8 4.1 4.6 4.1
Gross Pathology*
on Liver
Animals Killed;
After 14 Days
10th
After
Dose 10th Dose
11 1 11
--
His topathologyi
Animals Killed:
After 14 Days
10th
After
Dose
10th Do!
BB BB BB
_ __
trachea changes
In addition, the following tissues were examined histologically: kidney, brain, eyes, stomach, duodenum, thymus, spleen, bone marrow, pancreas, and were noted in any of these organs.
testis, adrenal
epididymis, lung, no compound-related
* Gross and histopathologic code
No abnormality detected 1 Lar ge and heavy B Reduction in number of centrilobular cytoplasmic vesicles
3
Summary:
"^'" W S S W
tflDrbLir8.rihlneirM0rat/kn"f
body weight; tingle doses of 7500 mg/kg and above caused large livers 14 day. after dosing
8 8 f
.. test
` C r " " days
* * Piod,
reduction in th, ,,,,her .! c t r i l . * X T t w TM L i c U . V' . ? S T " 'hl8tl"8" a ^ - e TM as a
after the 14 day-recovery period.
Ptopiasnlc vesicles. These changes were apparently not reversible
An evaluation of the results reported here and appe^^sj^ojjdicate that listing of the three compounds
is as follows :
Report by: tgju*JS>UJcuuJaJju
Laurel S. Wasileski Oral Toxicology Section
Approved by:
