Document rRXpZVroLwGko7QvOVYOLvMG

MEETING WITH: HEALTH & ENVIRONMENTAL S:i ciag^ECIVED MEETING REPORT MAR 1 2 1990 DOW CONFIDEENNTT!I;AL Environmental Affairs (full name, abbreviation, address) BASF Ludwigshafen/Solvay/ICI WRITTEN BY: Jan Wi1mer DATE MET: 02/27/90 WRITTEN: 03/05/90 Present: Gelbke, Hoffmann, Munk, Jaeckh and Druschke (BASF), Christ de Rooy, Solvay and Trevor Green, (ICI), Wilmer (DOW Europe) Guest: Dr. W. Dekant (University of Wuerzburg) Purpose: As a result of a review of the toxicology of VDC by the German BUA, more data are needed to explain the mechanism of the kidney tumor induction in male mice and to explain differences between species. The purpose of the meeting was to discuss a research proposal on VDC submitted by Dr. Dekant. Main conclusions of the discussions taken place at BASF were: - the studies should focus on the following aspects: a) glutathione//3-lyase pathway: formation of GSH adducts b) epoxidation of VDC in the liver followed by transportation of metabolites to the kidney c) P-450 mediated metabolic activation in the kidney d) studies will be started with Swiss mice. Depending on the results obtained in mice, species differences will be investigated in rats and human tissues (risk assessment). e) experiments will be carried out along the most appropriate route of exposure (inhalation). - the 4 companies expressed their willingness to support this 3-year research proposal (after revision of the present draft) - Dr. Dekant will submit revised proposal by the end of March which will then be discussed at the June meeting of the PVDC group - Dr. Hoffmann or Dr. Jaeckh (BASF) will be the monitoring scientist. BASF will help the Univ. of Wuerzburg to introduce Good Laboratory Practice (on a limited scale) - conditions and finances: standard contract between BASF and Univ. of Wuerzburg. BASF will recharge the other companies - proposal of BASF to share the costs (2QO,000 to 240,000 DM) on a equal base was accepted by ICI and Solvay, but not by Dow (proposal: "name plate capacity"). According to BASF's business manager Druschke, this was in contrast to what was agreed within the PVDC group (David Russell, Chris Dyball please clarify) - Dow USA will be asked to inform about status of VDC in the U.S EPA and ongoing activities within CMA (action: J. Wilmer) s062642