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Volume 55 Number 3 September 1984 H M Bolt: Editorial n<pe 149 J P Buchet. A. Geubel. S. Pauwels, P. Mahieu, R Lauwerys: the in,;uetu." of liver disease ("i the sitmn of ,ir vtiiio in humans 151 T. Shimada, Y, Sawnbe' Comparative studies on distribution anti covalent tissue binding of 2,4,?',4 anti 3.4,3 .4 tefrachlorobipheMy! isomers in it'd a: 182 K. Hemminki. R. Suni S f-:> -4 reaction of qiutar aldehyde anti acetaldehyde w111> nucleosides 186 A F. W, Morselt. D. Broekaert, E. J. JongstraSpnapcn. J. H J. Copius-Peereboom-Stegeman: IFsitv iiiMnii a! i ii.mii"s ai protein disulphide bonds tat live and Aduev a*ti t chronic cadmium ad m.uustiation anti tin1 possible 'relation to rnepilJo ;n..mem 155 B R. G. Dnnielsson l',.ii on*lil. Pansier and 1i i.-ailiupivei of cadmium a"d m-`u u-y dpe p*\;!nt*`n: .van dahmv utbam.ii'-s 161 G B. van dor Voet. F A do Wolff A method of sin-dying the aiteste-a' .|l< n:ii-<in -d .uuminium i.n mi 168 A Mutti, M Fnlzoi, A. Rornanelli, I Franchini: Region a-in:.limns of t:rai-- taitei ho'amines bv stvrene ........... - if m ,-abbiL, 173 R D Howland, H. E. Lowndes: f'eupner c nerve n'-o ami-: -.-i', in im clanude neuro;ia;i'v 178 M. I. Sabri Fui'be* i ibs.-rlimns on in vitro and in vi .'o effects of i i * * . * n * - d 111 n i; on glyceraldehyde 3 pfiosphafe liebvfifnoen.e.e 191 R. A. Jedrychowski, J A Soknl. J, Chmielnicka; Influence id giosu'e nmije i-n vinyl chloride ac tion 195 M. Macsimovic, I. Bregovec, V Deljac, Z. Binerifeld. Reactivate", id organoiiiiospii.ii" inhibited .'holm i`si"t.'iSe 4 i-yt.iisilkvIrarbrmyi subsUtuted t><s live 'nr-'. ieo-'i>ii. -ii-.-s 199 R. Kruszyna, H Krus/yna. P. A Doherty, R. P. Smith; Mvoot'-nsiv*- is of iiyriroxviainint* m intact am ",tM"tiy*-f! -ions and cats 203 Z. Ruben, G C. Fuller. S. G Knodle: Disobutamide munced cytotilastni-; vacuo'e;, m cultamd dog corn nary kii**-rv omst !* s.--11' 206 R&S 025982 Springer International , '* ' `` ' k , `, \ 1 ' , ' l,`l V` " '* .h--*.- .>^iiliii^i'iW^teiMii..Miu in. i ii i Him inliii i*nnn unniwM Af. h I .'vr. (< / ) 11 >' |`/- </ - 1 Toxicology < Sjuinper Vcrlay I9K4 Influence of exposure mode on vinvl chloride action Wix/artl Andrzej Jvdrxehowski'. Jerzy Andrzej Stikal'. and Judwicu Chinielnicka' Intitule id Ocinip.ihiin.d Medium', I icp.utnient id riixicitv l.satu mon, Ictcsv S, 'nn us,i I id/L I'.dam! hisimuc .d I.iKnoruiient.it Isese.mh and |lio,ui,itists l k'JMituieiit id luiitotoei N.irilti>wie,\i I'll a `HI 14' ! till/ Poland Mettled A. .[iletnt, Abxtraet, Kats were sul'icttcd to 4 h sontmuous tit uitcrmitti nl esposuto Iti x mvl clilor idc {V( 'I ai dilterenl tinie-weiyhled nicrayc t.onecrurations tl', 511. I'll. 5txt and Ivxxi me m'|. I lep.mc non-piotcm sulfhidryl content (NF'SI I) and excretion id tlnodiyh colic and | l ilf iA) in urine were deter untied. VC a: concentrations iiom 'Hihi;mi1 [o 1^,(MNl mym1 caused a ili'si- dependent depression o! NI'SII, but no differente in the muenitinlc id this dcpiession induced bv continuin'' or inii-i nnttent exposure at (he same average concentration of V< ' "ii' noted. At aierayc loncetitratioiis tit 5t) nip III' and 1'H nts; in', tin* unitary excretion of IdfiA under continuous exj'osiue iliil iiiit differ !mm tll.it under intermittent exposure. jxIkic.is at VC concentrations id Mx) my m' am! I s.ixx) my m' "a' lucliei follow mi: continuous exposure Key words: Vinyl clilondc - Sulllixdrxl croups - Tluodiylxcolid kuI Continuous ami intctntittcut expovue same axcr.iyc mfneatration ot \ ( . Inn experimental ex'tdeno" is laekuic The 'Host commonly postulated reactive VC metabolite lias been ehloroethx kmc oxide I Harbin et ai, 1975, fJartxch et a! 1979, fiiierieencn et al l`)7'i, IV,s|. /a;dela et al. IVSO), Ibis epi'Xide reurrancex to cfiloroaeetaliletivile. which can also least witfi tissue nueleopfules If iueiiycnch et al, 1979, I'/SI) anil lead to imitations (Malasedle et al. 197'; McCann et .ii I1*?.') It is assumed tlial the' primarx detoxication mecha nism ot VC iiimlses et ai nutat i* in with he .'ic ylutathione tollossetl fxv t!ie uioititi.a'.ion *d the peptule moietv, leaduic to suitiu-eont.immy unn.iix excretion ptoiluets ffireen and I lathwai 197'. atamd'e el al I*>.'f>a. h, e. l97.Sa, b. Mullet .Hid Notpotli l'<7>, Mu'lei et .il 1 x*7<>. 197S, 1979). Otu similes aim toiornpare the elicit id .iCute eotitiiHlims anil mtemiittcn: exposure id tats to VC on hepatic non-protein sulthyihvl content (NI'SII) and urmari excretion of thiodi- elveolic iienl I'ldfiAi, one of the major VC metabolites. liilriiilncliiiM I hit nip mu! chloride ;YCi ot pidximi! chloride il'VCl ['toiliiction the coneettttanotis id VC in the air .ire subieet to notable .hand's and thus the- xsoikeus mas he' exposed no. to i otistaut t mi t i.i xar table eons etitt a I ions i >f ilus moiiome!. Some iTimps oi workers, e y ile.uiets, mas pcriodicallx he expiiseil :i> sen (licit ioueentiatum ot VC seietal time' uteatet than the M \( ' x.ilite, I he uitlm-nce ot the exposute nioile on VC toxicity lias not been mxesbrated In expeinp.ental stmlies ol this subject, it would be adsisable to take into eonMilctullou the mam .!uec'"`n o! the adverse cites!' "t VC undci actual levels ot protessiona! x'xpiisurc, eaieinocenieits and ti'vie injurs til the hsei. sstiis)1 aiise as a consequence ot chronic inhalation llosiesei. sush studies performed on animals are tone-term and 'its expensive Thus, we hrs; undci took model studies ot acute t'sposiue. seeking m the results ot these uixestie.itions eiounds tot null,limy chronic studies. I :om annual stmlies it is obvious that the rate of VC meial'idistu i' dependent on the level ot exposure (th'inei et .:! I''"', t ichritu- et al I'd's. \>ataual'e et ,:l pfSti. I ilsei ami Itol. ll,'U) Hence, the txpe ot \C'oxposuie tltax dilfetenti.ite the toxicity induced by this monomer. Holt et al (19S|). on the s o! kinetic considerations, suyycsred that toxic effects xvith muons .uni intermittent expxrsute should not difter at the I..... M A k" '' i - how si i Materials and methmls Male Wisi.u rats, bin!', weii'ht .'so t 2' c. were subjected to ill ioiitimious oi intermittent exposure to VC at the same tuue-weiyhicd aier.iye eomentiations ol 15, 5o, 1st), 5t**) .util l.'.txm my in m tt'\ni`hi,*iLal chambers of ti.25 m1 vilume, lintet contmuous exposute. the VC concciutations were constant ihirmy 4 h udial.itmii The intermittent exposure mxoived toe !5 mm jieak concentrations id V(,' and h)ur 4(1 nun mt-rials without inhalation of VC (l-'ie, 11. Control 3i.,_n n n HV. t. I IHIC y x HI I NO 't \ ( . > `ffy tU!f .)! lx if l IJrj.IiM . y-Mf MUl' *UX < ' *iut i m 'T'-ti1 ^il 1V , .*