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|'t It |r\. | m ih.- Ik. r nl i.i11 In^lirr h.r .ilwni It hr .ihrr KC- VKt lrr,ln,rnl xiv. n nr.ijly an,I n.it Inwrr
it, 11, ill,- |'( II l.I hi ,,,li|wr inur .,li. i H hr. iln' t < !-|>.,ll`f n .4 |M 41 \i,,,r,| n, Iku, m-.i* ilill.Irmu
ill.,I i.Hill,II,I Kl!, Ill'll. . i in K Out all < <.iii|Hinrnt v>nr n<,l mi l.it Ji/r,| ,,i i|,r ,.nnr rile ami thal ihc
I .iiiijM.i,, Ml* i.l iln K<: ** ilh 'hr ImiX'f ii l.'iihmi Innr M.ir ini 1 .l-,li/nl In a |r.-r .l.^irr Ilian tlnnr with
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ll-ftT-i (I'olia pharrutcoi. ;<tf>on.) 71. H'.i-W7 (1976)
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MOMS 085886
I A \> I , , I 1 ': \7 U.b. COUt |
956 ft Ml J), <1 fi>
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4^11'< T l.t; VI/ c tt-* f~.
IM it :> 1 7 U - <V 7.00. tnO. COO, 000
UK KC-iOO, KC-tOO. KCC-'AM, K0(.00> Vffl
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Aatantlort CwhrwTwrojfrapby ('li-ECD) pattern* of varloua Kaocchlon u*d In till* Mudy.
NVmbulal* 4f/flV\ fltf-Klt-** A'Cti pentobarbital LX 50mg/kg V, > r
-cn#it y>m*.kj, a-cu z5mg/kf
fc.
fluM'f u nK4t*>in4>*H*?*NiMn4 u
IF I f /-K 9 m -A P-450, b (Cyt. PH50. Cyt. b.) *>jr,li Omura and Sato*
*/*fc*>*-T/v#fffTiF* omt. ittioo,2j.M 'iRff;wT+**'*-'fXL.
WOOx K. ISfrUGhflV 105000-x t. 90$>*t-OL. I p /-a j>Pi*W/S.
0.I5M l||
9 frAKVttTftofcO*,, 0.15M
UTKKKVIf^:*fc. Cyt. P450 *1 dithionita
:3*l 9*'/-*>W]}r> mvtflc
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F/V* 4 490n
L X. *fc Cyt. b, It NADH tli
f >A-*409nm
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MUNS Ud587
-TIC!*! THIS MATERIAL MAY BE PROTECTED BN
I'CH
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J.lt S `,l-f> ''K.fltt n -7- 9 MKKI inK.'ktf. I HlAurtV-L. --/rlS'ir^l^ - ix>ui.t>.>rbital r. i U*
Kg. *
5 l-.Vt 5 7- * -^WV *
AW(V (>'l2CKiifr//*A
r,h/ . -. ^lUiOlll.i kc.-sn-ct'<. >I'1W<o|`m ttii 1 CJfl/MT*. fti ? KO-HiO a O j |<J,
KC-MX), KCI4W AM .s- i C, ^ Z-.M R*V.WtV U f Ufl
--9 KC-300
Hg. 2.
I*it*i4inr()ilftl tlrrping time of rusk ICK mim mice after t>in( Cueing of KR (IO0 mg/fcg). Control mice slept for !-?0 min. Each point rrpreamia the
newt lor 3 lo 8 mica.
Fl|, 3.
Pmtolufliilil flerping lime of male ICR strain mice aflrr oral riming and intrap* triinnral injection of KC-300 (100 mg/ kg). Each point rrprMmtt iht iiwmi lor 9 lo 8 mica.
fig 9
KC-30Q fc ICR
100m*/
kg. I ["Itt'y-L.
tt'/ft5-6**MU *
caifnttV^/^4Kitrtmil^L. UfttWeMUglgtt. ttuft^owftiaiiCKftfMafl >dflfcnVrW**->knnii**M, JBK'Pl,>-ofj2inJ:'i*htr;l2iwnmr*9. UUof)i
2) PC
ICR *fcf,[*IS AIN #.rtr**l K0300, KCOOO * I00m*/kf,, Jp1IM3ft*U tt'MtSRtMfl
I* |<mtnl.tUnl
Table J K>7<T 5fc. WN *t * AfcJrfVT (, KC 300
pentobarbital 50 m/k(
ICR #-e* AOfttlRVfO
*(Kk>MA'g3^>TA*OI-t. dd.V
ICR *'e* AOtf/2
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MQNS 085888
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Table 1. IVnu.'jath.til i!r l'l,K w >4 i< tn.ilr ILK nml il..IN main n,.tr
ulur
.l.ai.:. -.f K(J (100 n.x.kg).
KK tfifN
(.xCllUnl
ni.* f) (ion)
H/7 .* 76 (100)
Sleeping time (trm) KC-JUU
:vx> ^33-- ' :mv2) 3H 03**
KO- 'AHJ
iw * n* uaa) 1**7 < 7U ' l)
I'r oil >)i.i 1 hit. ,1 .!rr,ii.^ nine v.
mrctl 3 tir afirr KC >:i^.ifmrnt. .N'ihi.Ikt in
paMntVm.k imiirjtt* (hr firrcfi ii!\i;f ui cormpomling tonirnU. Hull . aiuc rrpirxnti
Ilir mr.iti ly r t< to 8 inkr ami S 1).
!<<)<i'j
l'<o.uoi
d*yt
day*
Flf. 4.
Pcniotiarliital tlrt-pinx time .( female ICR un<) <ldN itrain inke after oral drain* of K(* (100m* V*). P.acli [mint rrprrtmis the mean for } in A mkc.
1. au
kc-'joo
ms
nu cat *
*r.nttimGaf_nrmtL,
mink.mwis-c. n
i*cb ntf-tntt-zuMeum'>}fkirni/>-*>i/>>, 4tsn-itomfiufA'hMw-vnum
dWK-notttv?ifc.
r. * onak w ea m o 1m$ ft 0v,'*v*1.
ic *-**-m kc-300, Kojoo i *,
otfiv^u ttv-ita
-)s utiN ^-r-y/.oiifujMi.ijavKininfti-inin
*<, Pt'.tt tt'> W2iHUi-i-;'.''CC KC-300 ttO-CT'CitWfrom^. KC-.WO v-nt?fi*iinrr^^40*
fuaao^-iifc'+oHWuaK ICR
2. 9-HC*WMUI I) Vr MlMtiWirKWWn'fflUOV't
SPiftlt?' Ml&Nk ft * 9 --.vfc 100mf/kg,
mKfrartftfc. n*. a h*<omi*v*l^a'*.
+
--&iVMltll prniobiwUcal Ci tMI
iiiiini^-fc. cowftvus mioiv/i-cti. -trjhK&nm*3ii* f|n aw*4 nnUSHi^-s-taRfto^i.. PU* (tgttk.fMlfctt*
xbhhtxtz. un.
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MON.S U65dS9
tio ,'IC: THIS MATEUAl MAY DS K.OTfcCT 0 bY
rcn >sf i * * /-aw*ji*
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KO3U0V
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u'^o^njiiv^urai-f >T. 1A: Kc-'X)0
WVTimSOliin
fee-* f..
-
imt 'kii). ('i-niM'l .' 'lr|a fur '<(1 -- 70 min l .nli |:><in< r ]M*> r>li llrt- iir.ni fur 0 to / fit.
'll* :ilniinisrrrd ]
wrrr l'\, '<0 and
100 in* V. F..u I) point m|>i rvnu tlw im-.ui
for (j to 7 rota.
tk'. (-. ITH
W> .......... .
r.i
M)j?fdJ>r 1-r. Kc-'iOO V
rm;h. ,.0m.|{>k1 hw h-kV*. I I'll f 11 ft l. Irf-.M.'iSVtfVi: L 7: ll'i*. li). i CWO/Wx-l '/-. I'^H
W V I*, i '.W-Xl'.H id >11a V-i * '>*?:;. -IifllMH />.!'/4 - >.
FjiiA:.
, * MM;;f 611 ,ril'A- r IX. I IK* ' 4M vr Hi KO'jMI V lOOmg/fc* ftV l /
. * * <0
M / * II- IIIOm.mAk n'/Lt-AUtyUV,
rtrtO turvr ujaim-?. L/iA'*-c !'<-
Sleeping tune (% o f C o n tro l)
rncAn for A lo 9 ran.
_ __
_____________________ _____ _
Y,:!'_;;i LAV/ I : i 1 LL 1 / U S. CODU ).
MONS 085890
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a in
n. Ji D*
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iiJI..'f.i- *' (, ^ 4 /{ bh b. A:prmnbarhitai oft ' giM.ifii 5f)ng kg. & I .; ?,* -'rr / y V O T i A i 50 -- 70') "Cft *> , pri.iotj.ulnCal *of <C.'? t 'il". 11<1 /?/5* ft
-/>
I'C.U {2'j i- ? r.Z? .`I'-jt'.'.:)
i > ft/: A*. ; S C -o ft: T5 V. T-' ^ A:
r-., s|) r., \Vi*;.ir if-, IVnryu
r Vi'. KC-JOO, KC-500
h ih I |. 7f N ft '/ |_ ,S..C8'|5'\it
i-k- 7 ii ;,f: %: kc.3', kc-.oo y_
7) nj : .> - /-- a (:>. P-l'A Cyt. b, ^
X*)1) ' h:a'iji'-:!i ::ivf:!i niASri ?*/-^ i *o ft r * - a ft a *. *>fV!f* * !>h & /: *>-.. si) * r!?:-r I r. (V4 `t * ? *UX)mlgt I : 'fltlftVL. Cyl. P-'t.'iO frOtfll Cyi. ftHVlMVYjr.,*
'Jt.';. I; r- Cy. r-w fta^ir>Vc'r/j'.LfA-. fcUA L c, HtfUvPMA (>< M5Uftato
,;i; r'ihb. rcn R*>-^i2iiK..1ilr Cyt.r-r.0 ft
f,\ i- ,< .'* 6 A Cyt. r-so
L
KC-300 -ct:V- < ft'V'fT 1- *<(, /,. fli <. L4*/.:.
fig. 8.
day*
I.i\ rr mir rcaomui f yot tiMniie P-4'(0
<otilriiu <i( triii.ite SJ) *iraii> rad after 01.il iloiiiiK of KC (Int)mg,kg). Sfran control value w,-u 0.70ft nin/kg protein. F.ai h point repreamti Die mean for 3
Pig. 9.
f ivrr micrwmal cyi<n liromr b rm< trntt of frmalr Sf) train Ml* after oral <!< >ing of KC (lt*J ing.'kg). Mean (iHttrol valurt wai 0.3H7 rim/mg protein. P.ach point reproenti the ine;in for 3 rati.
-i/J Cyt. b.Ofj (Fig. 9) ti Cyl. r-450 (0&A U'> Iff ft 9 , PCD ft
KC-300 ft
*>rr cfliftfltfM'iR*-*/*. la*l, i4Kttgii-LfcA'**x^ixoa*Ro^.* pcb uf eyt. b, fto
mX^JU Uv*f-. ft/i Ptt *> A * c>t. P-450ftftOJfl>;li KC-400, KC-500. KC-tJOO
cyt. b,
IF i pi/-ai|o Cyl. P-450 ti.
i'i-ft-*
X Alvarci f:m ti. MWfJ.lifi ftft
PCB
Aracloe 12S4 *> H--HV'C, 3-mhylcholn-
thrrnc *c;' *).? h 4 O i Kill!, 5/XTt/;!- CO-
t-zV-C 44finm 1^ I* AM<tfr*Vf.
Cyt.
P-448 o cx>-
7^'hftc A Vea^Lfc.
i-*CX*)3/t|^hfclf I P /-A Cyt.P-450
t*A. rig. 10 li^-rxiic 4400m
cyt. p-i-io'*,*$*
Mtf-WsffttL'itZ. LD-C-IO Cyt. P-440 OKzTIit. KC-?00 ft>f *J * MCH^t X't ft'fl
**
WTIi:*IIl-Fil-> C>t').
PCD R'>t* Cyt. P-448 OH*,?K4i Ah^C.
3) Vf.;p-/vft'>5r UDOLflW' WD Iflifftcot.-C v-Atm* voma-f pcb sMk'MHMomtzuifzmt.'c#*9*ivf?7i-z
MONS 085891
961
Wavelength (mp)
Fig. 10.
fJCVdillfrencv 5j*rttrtim il liver mirriMinn from r.t tr;trH with KCtiOO. TJtc 'Miirul i ll n.i* x*'"* olive 1 l"iic- Twrlvr Ihmh after trrtiunriit, COdillrreiHe i|>riiiiiiii were determined tuin^ mil rutumn opdvnU-nt to I mg protein j r i il <<( 0.1 M phmpliate liuiltr, pH 7.4.
J r AlfJt- KC-WO SI)
-) v HZ IWmg/kg, l Htf 11 ft V L. ttV1ft'.1!) 1 Cv'Jfltfl
-|i kc vki
tig. n
#f. ff.
`OfHh-'JtWW <. iVS-rjuiJJtJ'Cfl
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if.UVi'Jt-'KiWi<|'o !; iCrOil-rt'j I^HU-VSHiiilWfc'C
f:i - . .*
9, 'ti*!. \UKW.\f<;V'-tri. ^-}V| VV.|H)0/J*-C.IS1.
*> l*U A-JItt*-/!! ? W-WUXiMi
V'Yf i *.-/-A > > * >*-A^av'/j.'Sll./: ; * ir.'U' C, JKtfjIURM'O p<.1*
t,, t ig. w
'.iuiljf t */ JU4* CflMUVI'* mi H> ^i::;rivi/to*
6 : ^//'
^ 4* CA*. Fig. rj -0 <,')*,/)/* i 'Jt-,
kc-mo. kc.
W) ciit!li:',iist.VlM'
m*Kwv>*JBmmU'soKNOTr-ffilCn|V1'A*..I%clvbOMi
Wilt,.
i'ui frvm i > /-
i ujma.ok*.
PCS ooncntfUbon(ppm)
rtf. II.
IT; level* In ilwia of umIt SI) main rat* alter oral drain# of KC (100 tng/ kg). 1'arh point rrprmnb (Ik mean for 3 rat*.
Fig. 17.
mi level* In adipoae tUue* of female SI) itrain rat* alter oral ikeing of KG (I00rng/fcti). Rath point rrpreaenU the mean for 3 rat*.
MQNS 085891
{
'*i
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1). ft a*
'*. > i*. i-Lt *
'H r.( i>
n: }>>
r > a *c?3 io t' - > r.'/;!h/.a*.
rjr.hr *:-* t t i* }. f*< v cr.L
':3iRo v. &'/ r-.r-', - * />>.,5.
4 :. ;
t y > * i o ^ -'r `- J^k1-
a-a.;,
f-? if- <o*nM
jiov-c',JtLr.
rig n. PC It U%-U i.m.*-* ..f ..u.lr Sl> Mn.in rat aitrr **!
,f KC V*l MOO
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MQNS U85897
