Document pBOKGeRLDD3YbjyXkBroYyDVj

Attachment 3 VV / W J CANCER PREVALENCE IN SUBJECTS EXPOSED TO PERFLUOROOCTANONIC ACID (PFOA) James Dahlgren MD1, Ayman B iarahimMD* ,2,3,,Raphael Warshaw2, Earpreet Takhar MFH3 4 1. UCLA Seite! of Medicine. 2. Comprehensive Health.Screening Services. 3. Dahlgren Medical Group Please address correspondence to; James Dahlgren, MD 2811 Wilahire Blvti Santa Monica, CA S043 Voice: 310-449-5525 ext 226 FAX: 310-449-5526 dgM.sgsB@eaviroraxicology.com Key wards: p f o a ,p f o $.p f a s ,CS, cancer, prevalence, cnvirorueeewl.expuauie,fhjOTccbencal* Session: Perfluorinatsd substances LE 1828 soo/coo IXVNNIOKIO F9S1 S0J0T8C8 T:31 td/80/tO "1S I c l I U J UH Hil fl @ 004/005 Psrfluorocctanemc Asid (PFOA) is a man-made perflorocctasol chemical, which is also referred to as CS. PFOA is a key mgrsdiant agent in thaproduction.of Teflon and other flucrcchesBoal products and is biopcxsistent and bioaccuznulates. There has been documented chronic exposure to FFOA of the residents near a plant using PFOA and other fluoridated contaminants. > Our aim was to compare cancer distribution and cancerprevalence rates in a FFOA-exposfd population (resident) to list of the industry cancer registrydata from en occupational exposed population sad finally to tha general population (SEER). We performed aquestionnaire on 599 residents living near a PFOA using msaufecturing plant operated by Dupont Cancerregistry data, from the PFOA Dupont workers was made available through, discovery in pending litigation against Dupont and was not previously made available to fee scientific community for review. Tbs SEER data was used for comparison to fee general population. The ovwill cancer prevalence rare is higher in fee PFOA-jaxpcssd population when compared to the general population. Comparison of cancer prevalence ratea fer the industry cancer registry data, resident data and SEER is shown in Table 1. Our findings indicate that tha PFOA exposed residential population and FFOA-exposed workers have elevated cancer prevalence (Table 1). Prostate cancer in the residents was proportionately elevated among young age males. Csrvix and uterine cancer rates in women were also higher in the resident population compared to the U.S. general population. The distribution o f cancera in the residents and works is different than expected. Ofnote are fee findings of elevated prevalence rates of atypical canee such as Non-Hodgkin's, Leukemia, and Multiple Myeloma. Thi3 data suggests that exposure to PFOA may alter cancer distribution in exposed populations (worker and residents) and may be an importantrisk factor for as excess of cancarcases. SOO/OO IIVKMI0NID ERSI LE 1829 80SQT8C6-S 91 SI t 0 / 9 0 / 7 0 o to o V>. o X ~ to >o > 1 9 ts&h cincinnati Table I. Total Prevalence Rates io Dupont Study, Resident Popritalkm, and US Papulation Dupont Study Resident D ata U .S , D ata Dupont: US to n d o n i: US A Type o f Cancer Cancers Population Rata Cancers Population Rata R a te B la d d e r ie 5523 0.326% 4 589 0.668% 0.110% R a tio 20I R a tto 807 Bono 3rain 2 5623 0.038% 0 599 0.000% 0.010% 3.62 8 5523 0,145% 0 599 0,000% 0.020% 734 Breast 8 1034 0.774% 6 301 1,893% 0070% 009 2 ,2 0 C e rvfe /U te rt 1 1034 0.087% 11 301 3.654% 0060% 101 6001 Celen & Rectum 32 5523 0570% 4 588 0.686% 0340% K70 1,06 EsorhapuB a 5523 01)54% 0 589 0.008% 0004% 13,50 H odjM n's 4 5523 0072% 1 589 0.167% 0.020% 3.02 805 KJdnay Larvw O ralC avity 18 5523 0,328% 2 589 0.334% 0070% 4.68 6 5523 0.108% 0 589 0000% 0.020% 5.43 11 5523 0.109% 2 599 0334% 0.050% 3.90 4.77 6.B8 Lewtem a Uvei jn j telnam a M yabtno M on-tadflltln's P a n re a s v16 4 64 17 9 9 9 5523 5523 5523 5523 5523 5523 5523 0.280% 0072% 1.158% 0.308% 0.13% 0.183% 0.103% 1 1 7 4 2 5 0 599 0.167% 0040% 7.24 589 0.187% 0006% 12.07 599 1-180% 0090% 12.08 599 0.650% 0.120% 2.57 599 0.334% 0.010% 1600 699 0035% 0.08001 2.04 599 0000% 0010% 1609 4.17 27.82 1208 ' 5.56 33.39 10.43 P rotate S toracfi 19 4489 0.423% 9 288 3041% 1.180% (U S 2 S523 0,830% 0 599 0008% 0014% 209 202 T e s te r fb yiW r o il 5 4489 0.111% 0 280 . 0080% 0050% 2.23 3 5523 0.054% 1 5119 0.167% 0050% 1.09 309 5523 5.595% 80 539 10017% 2.080% 2.69 3.34 4.02 *Betta t ll Rnt brbltgnanl Pnufy g ` tjoin TilJilOburti o I