Document nmrNn4jzJ98d8E7oyoaebzewR

BIO-MEDICAL.RESEARCH DOCUMENT DESCRIPTION FORM 63 68 69 76 Duplicate in all cards:--^ 29ZM`ft l 0 year as-1961- File number [Right justify [Numeric only] Author(s), as Last Name FS (No Punctuation) and coden for journal as JAMA preceeded by one blank space 1 20 21 S'rtTK/S-^'.'CZj (S'?-ZjTA'JZ/r'C; rr, 40 41 Zn/r> _______ f 77 78 L. Sub-Index Code 60 61 62 11 12 13 Title of Report; end with space-hyphen-hyphen-space. Follow with Index Terms t separated from each other with comma-space. Avoid other punctuation; do not abbreviate. ,, ---- y-.y S&Z / *'< i-V/' >.. t. -- Si-iif S' S - //_S--''->->-*v'`r7/' *-v ?. i i cy-, y / '/ ,/v'.?'/' >' /> ? ~ S f , v_--y ' -- .'(f''K~7i-- * 21 22 23 24 73 99 CO o tfi <0 Source (Journal, Vol., Number, Pages, Date) 12 sTT,;*: // `S 6 // -t i Te'j'/ ~ ,(.'4 61 62 31 32 Brief Summary 12 10 SUMMARY: 61 62 61 62 63 64 HISTOLOGICAL AND ELECTRON MICROSCOPE STUDIES UPON THE LONG TERM TOXICITY OF VINYL CHLORIDE IN RATS, WITH SPECIAL REFERENCE TO LIVER CHANGES J. STETKIEVICZ, J. KOLAKOWSKI, I. ZDRAJKOWSKA and S. SZENDZIKOWSKI Institute of Occupational Medicine, LbdPoland Light-microscope studies were performed on internal organs and tissues including skin, skeletal muscles, bones, blood vessels and hemopoetic tissue of rats sacrificed after 1, 3, 6 and 10 months of exposure to vinyl chloride vapours in concentrations 50, 500 and 20,000 ppm. No evident pathological alterations were encountered in animals after exposure to vinyl chloride of 1 and 3 months durations. Histological changes were found in the liver of rats exposed to vinyl chloride at 500 and 20,000 ppm over the period of 6 months and in all three concentrations employed after the exposure of 10 month duration. The following changes were recorded: 1. Variable multifocal alterations in hepatocyte size ranging from decrease to marked cell hypertrophy, which becomes manifest and often insular after a longer time of exposure to both higher concentrations. 2. Parallel increase in nuclear polymorphism and in the number of binuclear hepatocytes. 3. Alterations in distribution and intensity of staining of the cytoplasmic basophile material. 4. An increased number of reticuloendothelial cells in the hepatic stroma. 5. Small focal cellular infiltrates composed mainly of lymphocyte - like cells, histiocytes and hemoblastic cells with occasional presence of bizzarc megacariocytes. Electron-microscope studies were limited to the livers. Following ultrastructural alterations were recorded: cytoplasmic hepatocyte changes variations of mitochondrial electron density and apparent swollen mitochondria with elongated cristae, increase in number of microbodies and variations of their size mostly accompanying mitochondrial changes, alterations in endoplasmatic reticulum distribution, distention of rough reticulum canals and variable smooth reticulum hypertrophy, areas of focal cytoplasmic degradation; nuclear alterations - nuclear shrinkage and indentations with distention of perinuclear zone, increase in nucleolar size and number; Kupffer cells changes, represented by an increased phagosome numbers and by the presence of lipide droplets. The histological and ultrastructural alterations observed are consistent with the criteria of liver lesions due to the other hepatotoxic substances described in the literature. They do not suggest any specific features of liver impairment under the long-term influence of vinyl chloride in the experimental conditions employed in this study. 542 /nTc r/i fl fstt'caTj 0 frt. ?r-36 & R&S 110593 BIO-MEDICAL RESEARCH DOCUMENT DESCRIPTION FORM 63 Duplicate in all cards:--? 68 69 TTTT '-f 76 133 year as-1961- File number [Right justify [Numeric only] Author(s), as Last Name FS (No Punctuation) and coden for journal as JAMA preceeded by one blank space 20 21 - 40 41 77 78 Sub-Index Code 60 61 62 11 12 13 Title of Report; end with space-hyphen-hyphen-space. Follow with Index Terms, separated from each other with comma-space. Avoid other punctuation; do not abbreviate. 12 61 62 ' N 2T 22 - - .. - . 23 24 Source (Journal, Vol., Number, Pages, Date ) 12_______________________________________________________________ -______________________ ' '/_*. ; ' * .' r 61 62 31 32 Brief Summary 12 10 SUMMARY: 61 62 61 62 63 64 Indu "rial F'giene Digest October 1975 1279/75 Chemical Carcinogens in Industry. R.L. Carter and F.J.C. Roe. J. Soc. Occup. Med. 25_: 86-94, July 1975. 72 refs. y 1280/75 Industry provides some of the clearest examples of chemical carcinogenesis in man. In this account the authors approach the problem from two angles. They first discuss some examples of industrial chemical carcinogenesis which have come into prominence during the last decade; they then consider certain broader aspects of the subject such as interpretative difficulties and conflicts of interest. In the first part they briefly discuss the polycyclic aromatic hydrocarbons, aromatic amines, some alkylating agents, vinyl chloride and asbestos. --Cond. from text Acro-Osteolysis in a Polyvinyl Chloride Worker With an Atypical Industrial History >*^.D r-s^3art, et al. J. Soc. Occup. Mea. 25: 103-109, July 1975. 11 refs. Acro-ostcolysis is described in a worker in the polyvinyl chloride industry who was not a cleaner of poly- meriser vessels. Threshold Limit Values in force at that time for vinyl chloride monomer in the atmosphere were apparently not exceeded. Haematological and biochemical investigations were normal. Radiographs of the hands showed the characteristic transverse bony defects in terminal phalanges. Digital arteriography suggested both ischaemic and inflammatory disease. Fourteen months after ho had stopped working with vinyl chloride the external appearances of his hands were unchanged, though, radiologically, partial healing of the bony lesions had occurred. --Author's Summary 1281/75 HCN (Hydrogen Cyanide) and Cyanides: A Guide for Nurses. E.M.Farr. Occup. Health 27: 336-341, August 1975. Cyanide in different forms is widely used in agriculture, pest control, in the manufacture of acrylic plas tics. in the hardening of metals and in the rubber, pharmaceutical and photographic industries. Cyanide is also the most rapidly acting of all known poisons. Symptoms and treatment are discussed. --Author's abst. 1282/75 Faiauiim AJiViinlstrsticn ir. the ft*y T'me Course of Inhibition and Recovery of Blood Cholines terases and Visual Discrimination Performance. L.W. Reiter, et al. Toxicol. 6 Applied Pharmacol, 1-13, July 1975. 22 refs. R&S 110594 The effects of parathion (0,0-diethyl O-p-nitrophenyl phosphorothionate) administration on activities of acetylcholinesterase (AChE) in blood and pseudocholinesterase (ChE) in plasma were studied in bonnet (Macaca radiata) and rhesus (M. mulatta) monkeys. In addition, the effects of parathion administration on performance of learned visual discrimination tasks were studied in rhesus monkeys. Peak inhibition of AChE and ChE occurred about 6 hr after administration of 0.5, 1.0, and 2.0 mg/kg parathion po. The de gree of peak inhibition was greater for ChE than for AChE, was dose-related for both enzymes, and was of about the same magnitude in both species, even though control values for AChE and ChE differed in the two species. Activities of both enzymes returned to control values within 2 wk at all dose levels. Admin istration of 2.0, 1.5, and 1.0 mg/kg parathion abolished performance cf the learned tasks 5 hr later and for as long as 3-7 days. When performance of the tasks returned after the 2.0 mg/kg dose, the level of performance remained below pretreatment values for up to 3 wk. A' dose of 0.5 mg/kg did not affect per formance. Comparison of the present findings with other work showed that reversal of blood AChE and ChE inhibition after parathion administration occurred more rapidly in monkey than in man but required more time in monkey than in mouse. It was observed that scopolamine and methyl scopolamine also blocked visual discrimination performance, --Author's abst. 1283/75 Methylmercury Poisoning in the Rat: A Combined Neurological. Chemical, and flistopathological Study. C. Fehling, et al. Toxicol. & Applied Pharmacol. 33: 27-37, July 1975. 15 refs. Methylmercury was given twice by gastric intubation to three groups of ten rats in a total dosage of 40, 20, or 0 (controls) mg Ilg/kg. The rats were examined neurologically every other day from Day 4 to Day 15, when they were sacrificed alter measurement of the motor nerve conduction velocities in the tail. The cen tral and peripheral nervous systems were analyzed for mercury and examined histologically. The 20-mg/ kg group showed transient neurological signs on Day 10, while the 40-mg/ltg group demonstrated signihcant neurologic dysfunction by Day 4 with signs of improvement after Day 10. The nerve conduction 21 BIO-MEDICAL RESEARCH DOCUMENT DESCRIPTION FORM Duplicate in all cards:--> ________ _ 68 69 3* J r- V -J year as-1961- File number [Right justify [Numeric only] Author(s) , as Last Name FS (No Punctuation) and coden for journal as JAMA preceeded by one blank space 1 _________ 20 21 40 41 77 78 Sub-Index Code 60 61 62 !/y^/y.. > AT. a,, / Title of Report; end with space-hyphen-hyphen-space. Follow with Index Terms, separated from each other with comma-space. Avoid other punctuation; do not abbreviate. ,, 21 s 22 ' 23 24 Source (Journal, Vol., Number, Pages, Date ) 12 n ;' 61 62 31 32 R& s 110595 Brief Summary 12 10 SUMMARY: 61 62 61 62 63 64 TRANSLATION Med interna 15:967-78, (1963) INVESTIGATION OF THE DISEASES PRODUCED BY VINYL CHLORIDE Dr. I. Suciu, I. Drejman and M. Valaskai 'n (Translated into French) From the Division of Industrial Hygiene and Occupational Diseases and the Department of Industrial Hygiene of the Institute of Hygiene of Cluj. The rapid development of the polyvinyl chloride industry in our country has raised for us a problem in industrial hygiene, toxicology and occupational pathology. In the aim of investigating this problem, a group of hygienists and clinicians have examined the conditions of work and the diseases affecting the workers of two plants manufacturing polyvinyl chloride. The clinical manifestations encountered raise the problem of interpretation of the ctiopathogenesis, of theoretical as well as practical importance, and of defining the clinical picture as well as of the necessary preventive and therapeutic measures. Our study was necessary in view of the fact that the existing scientific facts at our disposal were few and lacking in detail, especially as regards the observed clinical manifestations. Danishovskii (1) had demonstrated that the monomers, the starting products, exert an aggressive action from the biologic point of view. They have the property of producing destruction of the skin and of the mucosa. Some of them are allergens. They act on the parenchymatous organs by producing degenerative changes and on the hematopoietic system, leading to an anemia of hemolytic type. Hervieux and Tessier (11) found, among 145 workers of a polyvinyl plastics factory, 17 cases of chemical dermatitis.*** Pletsitzer, Bondar and Smirnova (cited, by Danishevskii), in studying the chronic effects of the vapors of vinyl chloride, observed in man the development of toxic angioiaurosis. * Dr. Lefevre given the reference as Medicina interna 6, No. S:963-77, 1962; in Index Medicus (6:N-1277, 1964) the above reference is given. The original is being ordered. ** In fact, in their account, the authors speak of 17 cases of "intolerance" or only 10 cases of pruritus, without eruption, of the forearms and of the face appearing in the summer, as seeming to be due possibly to vinyl chloride. R&S 110596