Document nm6LjbDXEm7xQVZqQ8NYm4mN6

CHEMICALS/PROCESSES CLASSIFIED AS CARCINOGENS by Jerry W. Newman Theodore F. Schoenborn Rodger L. TatRen April 30, 1985 Technical Information Branch Division of Standards Development and Technology Transfer National Institute for Occupational Safety and Health Centers for Disease Control Public Health Service U.S. Department of Health and Human Services 002561 LLA 001343 INTRODUCTION This compilation presents those chemicals end processes evaluated as .having carcinogenic potential by the International Ageney for Research on Cancer (LARC), Che National Toxicology Program (NT?), the National Institute for Occupational Safety and Health (NIOSH), the Occupational Safety and Health Administration (OSHA), or the American Conference of Governmental Industrial Hygienists (aCGIH). The table includes the category under which each agency or organisation includes the eonpound or process. A full description of each category is included in the notes following the table. It is hoped that this compilation will aid those interested in the development of a policy on occupational cancer by presenting the chemicals classified as carcinogens in tabular format. 002562 LLA 001344 CHEMICAL MAKE/PROCESS CAS KUM3ER 2-Acetylaminofluorene Acrylonitrile Afitinomycin 0 Adriaaycin Afla toxins Aldrin Aluminium Production 2-Aminoanthraq uinone 4-Aminodiphenyl 1-Amino-2-aethylanthraq uinone Amitrole Analgesic mixtures containing Pheoacetia o-Anisidine o-Anisidine Hydrochloride Antimony Trioxide Production Aramite Arsenic and Certain Arsenic Compounds Arsenic, Inorganic Arsenic Trioxide Production Asbestos Actinolite Amosite Anthophyllite Chrysotile Crocidolite Tremolite Other Forms Auramine (Technical Grade) Auramine Manufacture Azachioprine Bend a]anthracene Benzene Benzidine Benzidine-based Dyes Benzo(b)fluoranthene Benzo(j)fluoranthene Benzo(It) fluoranthene Benzo(a Jpyrene Benzotrichloride Beryllium and Certain Beryllium Compounds H,M-Bis(2-ehloroethyl)- 2-naphthylamina (Chlornaphazine) Bischloroethyl nitrosourea (BCMU) Bis-chloromethyl Ether (BCME) Boot and Shoe Manufacture and Repair (Certain Occupations) 53-96-3 107-13-1 50-76-0 23214-92-3 309-00-2 117-79-3 92-67-1 82-28-0 61-82-5 90-04-0 134-29-2 140-57-8 1332-21-4 2465-27-2 446-86-6 56-55-3 71-43-2 92-87-5 205-99-2 205-52-3 207-03-9 50-32-3 98-07-7 494-03-1 154-93-3 542-38-1 LARC 2A 2B 2B 2A ra m i 23 1 MT?2 A A A A 1C A A MIOSH2 X X OSHaX X M.R. X ACC*A2 Alb A2 A A A 1K M.R. A2 1K 2B 1 1 1 1 irtr* imtr t t 2a 23 2A K A K K A A A XX A2 X N. R. M.R. M. R. Ala M. R. N. R. M.R. Ala Ala M. R. Ala X M. R. A2 X Alb X A2 X M.R. A2 K 7/5 kK 1 X A1 a 002563 LLA 001345 chemical name/process CAS NUM3ER I,3-Butadiene 1,4-Butanediol Dimethane- sulphonate (Myleran) Cadmium and Certain Cadmium Compounds Carbon Black Carbon Tetrachloride Carrageenan (Degraded) Certain Combined Chemotherapy for Lymphomas Chlorambucil Chloramphenicol L-(2-Chloroethyl)-3-cyclohexy1- l-nitroaourea (CCNU) Chloroform Chloromethyl Mechyl Ether (Technical Grade) Chlorophenols (Occupational Exposure to) Chloroprene Chromates of Lead and Zinc, as Cr ' Chromite Ore Processing (Chromate) Chromium and Certain Chromium Compounds Chromium (VI), Carcinogenic Chromium (VI), Certain Water Insoluble Compounds Chrysene Cisplatin Coal Gasification Coal Liquifaccion Coal-Tar Products Coal-Tar Pitch Volatiles Coke Oven Emissions Coke Production Combined Oral Contraceptives Conjugated Oestrogens p-Cresidine Cupferron Cycasin Cyclophosphamide Oacarbazine DDT 2,4-Diaminoanisole and its salts 2,4-Diaminoanisole Sulfate 2,4-Diaminocoluene Dibena(a,h)acridine Dibenz(a,j)acridine Dibenx(a,h)anthracene 7H-Dibenzo(c,g)carbazole Dibenzo(a,e)pyrene Dibenzo(a,h)pyrene Dibenzo(a,i)pyrene DibenzoC a,1)pyrene 106-99-0 55-93-1 1333-86-4 56-23-5 305-03-3 56-75-7 13010-47-4 67-66-3 107-30-2 126-99-3 218-01-9 15663-27-1 120-71-8 135-20-6 14901-08-7 50-18-0 4342-03-4 50-29-3 615-05-4 39156-41-7 95-80-7 226-36-8 224-42-0 53-70-3 194-59-2 192-65-4 139-64-0 189-55-9 191-30-0 IARC1 l NT?2 NI0SH3 X OS HAN.R. ACCIH A2 2B A 2B A 1 1K 23 2B 23 A 1K 23 1K 23 *-* 2A 1 1 23 23 *-** *-** IMP* *-*'* a tra *-*-* K A A A K A A A A A A A A X N.R. X N.R. X N.R. A2 X N.R. A2 X A2 X-p X X X-? X-? X X N.R. N.R. N.R. X A2 Al> Al a ^ A2 Al i X N.R. X 002564 2 LLA 001346 CHEMICAL SAME/PROCESS 1,2-Dibromo-3-chloropropane (DBC?) 3,3'-Dichlorobenzidine 3,3'-Oichlorobenzidine salts Dieldrin Dienoestrol Diepoxybutane Di(2,3-poxypropyl)ether (DGE) Di(2-ethylhexyI)phthalate Diethylatilbestrol (DES) Diethyl Sulphate 3,3'-Dim*thoxybenzidine 4-Dime thylaainoazobenz ene Dimethylcarbamoyl Chloride 1,1-Dimethyl Hydrazine Dimethyl Sulfate 1,4-Dioxane Direct Black 38, Technical Direct Blue 6, Technical Direct Brown 95, Technical Epichlorohydrin Ethinyloestradiol Ethylene Dibrooide (EDB) Ethylene Dichloride (EDC) Ethyleneiaine Ethylene Oxide Ethylene Thiourea Ethyl Methanesulfonate Formaldehyde Furniture Manufacture 2-(2-Fury1)-3-(5-nitro-2-furyl) acrylamide GyromitrLn Hematite Underground Mining Hexachlorobenzene Hexaehlorobutadiene Hexachloroe thane Hexaoethyl Phosphoramide Hydrazine Hydrazine Sulfate Hydrazobetvzene ICR 170 Indeno(1,2,3-cd)pyrene Iron and Steel Founding Iron Dextran Complex Isopropyl Alcohol Manufacture (Strong Acid Process) Kepone (Chlordecone) Lead Acetate Lead Phosphate Lindane and Other Hexachloro- CAS HUMBER 96-12-3 91-94-1 60-57-1 84-17-3 1464-53-5 2238-07-5 117-81-7 56-53-1 64-67-5 119-90-4 60-11-7 79-44-7 57-14-7 77-78-1 123-91-1 1937-37-7 2602-46-2 16071-86-6 106-89-3 57-63-6 106-93-4 107-06-2 151-56-4 75-21-3 96-45-7 62-50-0 50-00-0 3688-53-7 16568-02-8 113-74-1 87-68-3 67-72-1 680-31-9 302-01-2 10034-93-2 122-66-7 146-59-3 193-39-5 88154-94-3 143-50-0 301-04-2 7446-27-7 58-39-9 IARC1 23 23 1 2A 2B 23 2A 2B 2B 2B 23 23 23 23 L 23 23 L 23 1 ST?2 A A A A X A A A A A A A A A A A NI0SH3 X X X X X X X X X X X X X X 0SHAX X X V. R. N.R. X N.R. N.R. N.R. N. R. N.R. N.R. X X N.R. ACsJ A2 A2 A2 a2 a2 a: a2 mr* 1 K A 23 r. *** im A A A A A < A A A A A2 X a: X N.R. A. -M X X N.R. 0025&5 LLA 001347 CHEMICAL NAMS.'PROCSSS Melphalan Mescranol Mechoxsalen vitn Ultra-Violet A Therapy (PUVA) 5-Methylehryaene 4,4'-Methylenebis(2-chloroaniiine) (MOCA) 4,4'-Methylenebis (a, n,-dine Chy 1) ben*eaa mine 4 ,4'-Methylene Dianiline Methyl Bromide Methyl Chloride Methyl Hydrazine Methyl Iodide Methyl Mechanesulfonate N-Methyl-N'-aitro-N-aitroso- guanidine Metronidazole Michler's Ketone Mineral Oils Mirex Mitomycin C Mustard Cas alpha-Naphthylaaine beca-Naphthylaaine Nickel Carbonyl Nickel and Certain Nickel Compounds Nickel, Inorganic Compounds Nickel Refining Nickel Sulfide Roasting, Fume and Oust Nitrilotriacetic Acid 5-Nitro-o-anisidine 4-Nitrodiphenvl Nitrofen Nitrogen Mustard 2-Nitropropane N-N itr os odimecny laaine N-Nitrosodi-o-butylaaine N-Nitroaodiethanolaaine N-Nitrosodiechylaaine N-Nicrosodiae chylaaine p-Nitrosodiphenylaaine N-Nitrosodi-n-propylaaine N-Nitroao-n-ethylurea N-Nitroao-a-aethylurea N-Nicrosomechylvinylaaine N-Nitroaomorpholine N-Nitroaonornicocine N-Nicrosopiperidine N-Nitrosopyrrolidine N-Nicroaosarcosine CAS NUMBER 143-32-3 72-33-3 298-31-7 3697-24-3 IQ1-14-4 69522-43-5 101-77-9 74-83-9 74-37-3 60-34-4 74-88-4 66-27-3 70-25-7 443-48-1 90-94-8 2385-85-5 50-07-7 505-60-2 134-32-7 91-59-3 13463-39-3 139-13-9 99-59-2 92-93-3 1836-75-5 55-86-7 79-46-9 62-75-9 924-16-3 1116-54-7 55-18-5 62-75-9 156-10-5 621-64-7 759-73-9 684-93-5 454 9-40-0 59-89-2 16543-55-3 100-75-4 930-55-2 13256-22-9 IARC - 3 23 1 NT?2 K NIOSH 3 OS HA" ACI A A L L 23 m* A A L 1X 1K 2A A 1K A A A 2A T A A A A A A A A A A A A A A X a: A2 x n.r. x X A2 X N.R. A2 X x a: 2 X N.R. N.R. X Ala X X X A1 5 A2 A2 002566 U-A 001348 CHEMICAL NAME/PROCESS CAS NUMBER Norechis cerone Oestradiol-173 63-22-4 50-28-2 0s crone Oxymacholone 53-16-7 434-07-1 Pesticide Manufacture and Formulation Phenacetin 62-44-2 Phenaxopyridine 94-78-0 Ptaeoazopyridiae Hydrochloride Phenoxyacetic Acid Herbicides 136-40-3 (Occupational Exposure to) N-Phanyl-beta-naphchylamine 135-38-6 Phenylhydrazine 100-63-0 Phanycoin 57-41-0 Phanytoin, Sodium Salt 630-93-3 Polybraainaced Biphenyls (PBBs) 36355-01-8 Polychlorinated Biphenyls (PCBs) 1336-36-3 Procarbazine 671-16-9 Procarbazine Hydrochloride ' 366-70-1 Progesterone Propane Sul tone bata-PropioLactone 57-83-0 1120-71-4 57-57-8 Propyleneimine 75-55-8 Propylthiouracil 51-52-5 Reserpine 50-55-5 Rubber Induscry (Certain Occupations) Saccharin Safrole 81-07-2 94-59-7 Selenium Sulfide 7446-34-6 Sequential Oral Contraceptives Soots, Tars, and Mineral Oils Streptozotocin 18883-66-4 Sulfallate 95-06-7 2,3,7,8-Tetrachlorodibenzo-p- 1746-01-6 dioxin (TCDD) 1,1,2,2-Tetrachloroethane Tatrachloroethylene Thioacetaoide 79-34-5 127-18-4 62-55-5 Thiourea 62-56-6 Thorium Dioxide 1314-20-1 o-Tolidine o-Toluidine 119-93-7 95-53-4 o-Toluidine Hydrochloride p-Toluidine 636-21-5 106-49-0 Toxaphene 8001-35-2 Traninane 68-76-8 Treoaulphan 299-75-2 1,1,2-Trichloroethane 79-00-5 2,4,6-Triehlorophenol Trichloroethylene Triethylenenelamine Tris (az iridinyl )-para-benzoq uir.one 88-06-2 79-01-6 51-13-3 63-76-3 (Triaziquone) IARC1 NT?2 NIOSH3 OSHA^* 23 2B 23 2A A X 2A A 2B A A 23 N.R. 23 A A A 23 A 2A A A 23 A 23 A 1 A A A 2B 1K A A 23 A A A X A 2A A A "A Tw 1 23 A L 23 X X N.R. X N.R. X N. R. N.R. X X N.R. X N.R. x. N.R. N.R. X N.R. X N.R. 02567 5 CHEMICAL NAME/PROCESS Tris(l-aziridinyl)pho*phine Sulphide Tri(2,3-dibraaopropy1)phophace Tryptophan PI Tryptophan P2 Uracil Mustard Urechane Vinyl Bromide Vinyl Chloride Vinyl Cyclohexene Dioxide Vinyl fluoride Vinylidiae Chloride Vinylidene fluoride Monomer CAS NUMBER 52-24-4 126-72-7 62450-06-0 62450-07-1 66-75-1 51-79-6 593-60-2 75-01-4 106-87-6 75-02-5 75-35-4 75-38-7 IARC1 2B NT?2 A NIOSH3 OS HA* acc::-:- irm A 2B A 1X X XX X X X A2 Ala A2 002568 6 LLA 001350 HOTES I. Compiled from: (a) International Agency for Umr:h on Cancer, LAIC Monographs on the Evaluation of the Carcinogenic Risk of Chemicala to Humans, Chemicals, Industrial Processes end Industries Associatad vich Cancer in Humans, IARC Monographs, Volumes 1 to 29, Supplement 4, 1982; (b) IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Volumes 30-34, 1983 to 1984; end (c) IARC, Handling Chemical Carcinogens in the Laboratory, ?robleu of Safety, IARC Scientific Publications Ho. 33, 1979. Definitions of the entries in this column, which correspond to the IARC classifications in Che above three references, are given below. Croup 1 [from reference (a)] The chemieal, group of ehemieals, industrial process or occupational axpoeure ia carcinogenic to humans. This category, wea used only when there was sufficient evidence from epidemiological studies to support a causal association between the exposure and eancar. Croup 2 [from rafartncs Ca)I Tha chemical, group of ehemieals, industrial process or occupational exposure is probably carcinogenic to humans. This category includes exposures for vhieh, at one extreme, the evidence of human careinogeniciey is almost 'sufficient', as well as exposures for vhieh, ae tha ochar extreme, it is inadequate. To reflect this range, the category was dividad into higher (Croup A) and lower (Croup B) degrees of evidence. Usually, category 2A was reserved for exposures for vhieh there waa at laast limitad avidanca of carcinogenicity to humans. The data from studies in experimental animals played an important role in assigning studies to category 2, end particularly those in Croup B; thus, the combination of aufficient evidence in animals and inadequate data in humans usually resulted in a classification of 2B. v* [from reference (b)] Tha chemieal, group of chemicals, industrial process or occupational exposure appears in IARC Monographs, Volumes 30-34, with at least 'sufficient' evidence of carcinogenicity ir. experimental animals. L (from reference (e)} Chmaicals listed by IARC as laboratory reference compounds 002569 LLA 001351 SOUS continued 2. Compiled fro* the Third Annual Import on Carcinogens, Sumery, O.S. Department of Sul eh tad Human Services, Rational Toxicology Program, 1983. Definitinna of the entriee in this column, which appear in eha Annual leport, *ra given balov. X Sobetances or groups of substances, and tachnologieal or manufacturing procaaaaa ehae art known eo ba carcinogenic. A Subaexncas or groupa of aubacancaa that nay raaaonably ba aacicipacad eo ba careinogena. 3. Compiled from tha SIOSH lacomaendacions for Occupational Safety and Raaieh Standarda. Thoaa antriaa narkad "p" indicate poeancial for earcinoganicity. 4. Compiled froa Title 29, Coda of Federal legulacioua, Part 1910.1000 at aaq., 1984. Entrias in ehie eoluan are defined below. X Thoaa chemicals or chemical claaaaa eurrantly regulated by OSHA aa eareinogena. k.r. Thoaa eheaieali or ehemieal claaaaa currently regulated by OSHA for reaaona other chan eareinogeneaia. 3. Coapilad froa American Conference of Governmental Indus trial Hygienists (ACCIS), Threshold Limit Values (TL7) for Chemical Subscaneea and Physical Agents in Che Work Environment and Biological Exposure Indices with Intended Changes for 1984-33. Entries in this eoluan are defined by ACSIH aa follows: Ala Huaan Carcinogens. Substances, or aubacancaa associated with industrial processes, recognised to have carcinogenic or cocareinogenic potential, with an assigned TLV. AlbBuaan Careinogena. Substances, or substances associated with industrial processes recognised to have carcinogenic potential wiehout an assigned TL7. A2 Industrial Subscaneea Suspect of Carcinogenic Poeeneial for Man. Chemical substances or subseances associated with industrial processes, which art suspect of inducing cancer, based on either (1) limited epidemiologic evidence, exclusive of clinical reports of single cases, or (2) demonstration of carcinogenesis in one or mors animal species by appropriate methoda. 002570 3 LLA 001352 00^59 LLA 001342