Document n9qBxzgbmKVwEBExR1LgeORB2

PFOA 3M FLUOROCHEMICAL SUBMISSIONS February, 2002 - May, 2004 TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE Click on Study Title to View Report Perfluorooctanoic acid PAGE 1, 2 Pharmacokinetic Study 1. A Pharmacokinetic Study of Potassium Perfluorooctanoate in the Cynomolgus Monkey, Southern Research Institute Study ID 9921.4, 3M Reference No. T-7507.1, January 14, 2003. [Submitted July 9, 2003] Repeated-Dose Toxicity 1. Final Report, CHO/HGPRT Forward Mutation Study -- ISO, (Ammonium Perfluoroctanoate) March 28, 2002, Toxikon Corporation, T-6889.7. [Submitted July 16, 2002] Reproductive 1. Oral (Gavage) Two-Generation (One Litter Per Generation) Reproduction Study of Ammonium Perfluorooctanoate (AFPO) in Rats, Argus Resaarch, Study No. T-6889.6, March 26, 2002. [Submitted April 2, 2002] a. TSCA 8(e) Notice of Draft Final Report on Ammonium Perfluorooctanoate (APFO) in an Oral (Gavage) Two-Generation Reproduction Study in Rats. [SubmittedFebruary 28, 2002] b. TSCA 8(E) Supplemental Information: Ammonium Perfluorooctanoate CAS#: 3825-26-1: Oral (Gavage) Two-Generation (One Litter per Generation) Reproduction Study in Rats, by Argus Laboratory. [SubmittedApril 3, 2002] c. Final Report, Protocol 418-020, Argus Research, Charles River Laboratories, May 1, 2002. [SubmittedMay 10, 2002] d. Raw estrous cycling data for P and F1 females from Argus Research Protocol 418-020, "Oral (Gavage) Two-Generation (One Litter Per Generation) Reproduction Study of Ammonium Perfluorooctanoate (APFO) in Rats." [Submitted September 17, 2002] e. A table (two pages) entitled, "Estrous Cycling and Natural Delivery/Litter Observation Data," which, in addition to data on estrous cycling, contains information on mean litter numbers of implantations, liveborn, and stillborn by dose group. [SubmittedSeptember 17, 2002] f. An analysis of P and F1 generation estrous cycling data made subsequent to the August 30, 2002 meeting and including colored charts which graphically represent the raw estrous cycling data. [Submitted September 17, 2002] 2. Final Report, PFOA: Lactational and Placental Transport Pharmacokinetic Study in Rats, DuPont Haskell Laboratory Project No. DuPont-13309, 3M Reference No. T-6889.11, December 19, 2003. [Submitted January 8, 2004] 3. Final Report, Ammonium Perfluorooctanoate: Age Effect on the Plasma Concentration in Post-Weaning Rats Following Oral Gavage, DuPont Haskell Laboratory Project No. DuPont-13267, 3M Reference No. T-6889.10, December 15, 2003. [Submitted January 8, 2004] Back to Menu PFOA TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE Click on Study Title to View Report Perfluorooctanoic acid PAGE 1, 2 Other 1. "Genotoxicity, Carcinogenicity, Developmental Effects and Reproductive Effects of Perfluorooctanoate: A Perspective from Available Animal and Human Studies,"Association of Plastics Manufacturers of Europe and The Society of the Plastics Industry, December 12, 2002. [SubmittedMay 11, 2004]